Frequency discrimination: Assessing global-level and element-level units in memory.

Assessed the retention of memory units for word-like strings of letters using the perceptions of 120 undergraduates in 2 experiments in determining how frequently various letters appeared. A series of strings was presented at 1 of 3 exposure durations. Within the series, the frequencies of occurrence of different strings and of the letters composing the strings were varied orthogonally. Results indicate that, at relatively long exposure durations, Ss could discriminate the frequency of occurrence for both strings and their constituent letters. The formation of global-level (string) memory units was indicated by judgments of string frequency being unaffected by either the frequencies of their component letters or experimental conditions (brief exposures) that prohibited accurate judgment of letter frequency. Although judgments of letter frequency were sometimes biased by the frequency of the strings containing the letters, the success with which the judgments discriminated different levels of letter frequency did not depend on the activation of string-level memory units. Furthermore, Ss' frequency judgments for letters were not predictable from their recall of the strings containing the letters. Results provide evidence for the formation of element-level (letter) memory units. (21 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Analysis of clinical trial data: The problem of outcome overlap.

The immediate goal of any clinical trial is to determine to which of a specified set of treatments future patients are to be assigned, particularly when analyzing data from clinical trials. When the outcome distributions of Experimental (E) and Control (C) treatments overlap, differences between treatment group means are not conclusive and may not be very informative, so a display of the overlapped frequency distributions and a summary measure of the probability of a random patient in E doing better than a random patient in C are needed. When outcome distributions overlap, the question of statistical model becomes crucial even when there are very significant differences between group means and very large effect sizes. Determining what patient variables interact with treatments is the route to optimal assignment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Application of a Compaction Simulator to the Design of a High-Dose Tablet Formulation. Part I

The compaction properties of an investigational drug are studied by the use of a compaction simulator. The effects of punch velocity over the range of 30-640 mm^-1 on the compaction properties of the pure drug and a variety of formulas incorporating a high dose of the active compound have been investigated. The data were analyzed by applying the Heckel equation. The pure drug was found to have a high yield pressure at a relatively low punch velocity of 31 mm^-1. As the punch velocity was increased there was a decrease in crushing strength, primarily as a result of increasing yield pressure. These findings indicate that the pure drug predominantly consolidated by fragmentation and elastic deformation, with a slow plastically deforming component. The information obtained on the consolidation mechanism of the pure drug and, subsequently, on model formulas were instrumental in the design and selection of a robust formula and granulation process. The advantages of conducting dosage form design and characterization studies during the early phase of tablet formulation using means such as a compaction simulator are emphasized in this investigation.     

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan-transport defect in kes1Δ or osh1Δ mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.     

Accounting for the use of behavior technologies in social psychology.

Considerable scholarly effort in social psychology is devoted to the development of techniques that change behavior. In this article, the social and political forces that have guided the development of these techniques are examined. Also, ethical and psychological issues associated with the use of behavior technologies are discussed. These issues arise from the fact that to change behavior, it must first be controlled. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Casual reasoning in planning1

Reasoning about actions necessarily involves tracking the truth of assertions about the world over time. The SIPE planning system retains the efficiency of the STRIPS assumption for this while enhancing expressive power by allowing the specification of a causl theory. Separation of knowledge about causality from knowledge about actions relieves operators of much of their representational burden and allows them to be applicable in a wide range of contexts. The implementation of causal theories is described, together with examples and evaluations of the system's expressive power and efficiency.