Optimization of hole-making operations: a tabu-search approach

This paper reports a tabu-search approach to minimize the total processing cost for hole-making operations. Four issues, namely, tool travel scheduling, tool switch scheduling, tool selection, and machining speed specification have been simultaneously addressed in this study. The total processing cost consists of tooling cost, machining cost, non-productive tool travelling cost, and tool switching cost. This problem has a structure similar to the Travelling Salesman Problem (TSP) and hence is NP-complete. In addition, the problem under consideration is more complex since the cost associated with each operation is both sequence-dependent and position-dependent. To provide an efficient solution procedure, a tabu search approach is used. To improve the search performance two new neighbourhood generation and move selection policies have been proposed and tested. The decisions on the above issues can be made simultaneously based on the output of the proposed algorithm. The results obtained from computational experiments show that the total processing cost can be significantly reduced within a reasonable search time. The effects of some search parameters and diversification strategies on the search performance have also been investigated.     

Oxy210, a Semi-Synthetic Oxysterol,Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization

Inflammatory responses by the innate and adaptive immune systems protect against infections and are essential to health and survival. Many diseases including atherosclerosis, osteoarthritis, rheumatoid arthritis, psoriasis, and obesity involve persistent chronic inflammation. Currently available anti-inflammatory agents, including non-steroidal anti-inflammatory drugs, steroids, and biologics, are often unsafe for chronic use due to adverse effects. The development of effective non-toxic anti-inflammatory agents for chronic use remains an important research arena. We previously reported that oral administration of Oxy210, a semi-synthetic oxysterol, ameliorates non-alcoholic steatohepatitis (NASH) induced by a high-fat diet in APOE*3-Leiden.CETP humanized mouse model of NASH and inhibits expression of hepatic and circulating levels of inflammatory cytokines. Here, we show that Oxy210 also inhibits diet-induced white adipose tissue inflammation in APOE*3-Leiden.CETP mice, evidenced by the inhibition of adipose tissue expression of IL-6, MCP-1, and CD68 macrophage marker. Oxy210 and related analogs exhibit anti-inflammatory effects in macrophages treated with lipopolysaccharide in vitro, mediated through inhibition of toll-like receptor 4 (TLR4), TLR2, and AP-1 signaling, independent of cyclooxygenase enzymes or steroid receptors. The anti-inflammatory effects of Oxy210 are correlated with the inhibition of macrophage polarization. We propose that Oxy210 and its structural analogs may be attractive candidates for future therapeutic development for targeting inflammatory diseases.     

Design,modeling, and analysis of a high performance piezoelectric energy harvester for intelligent tires

Basic parameters affecting vehicle safety and performance such as pressure, temperature, friction coefficient, and contact‐patch dimensions are measured in intelligent tires via sensors that require electric power for operation and wireless communication to be synchronized to the vehicle monitoring and control system. Piezoelectric energy harvesters (PEHs) can extract a fraction of energy that is wasted as a result of deflection during rolling of tires, and this extracted energy can be used to power up sensors embedded in intelligent tires. A new design of PEH inspired from Cymbal PEHs is introduced, and its performance is evaluated in this paper. Cymbal PEHs are proven to be useful in vibration energy harvesting, and in this paper, for the first time, the modified shape of Cymbal energy harvester is used as strain‐based energy harvester for the tire application. The shape of the harvester is adjusted in a way that it can be safely embedded on the inner surface of tires. In addition to the high performance, ease of manufacturing is another advantage of this new design. A multiphysics model is developed and validated to determine the output voltage, power, and energy of the designed PEH. The modeling results indicated that the maximum output voltage, the maximum electric power, and the accumulated harvested energy are about 3.5 V, 2.8 mW, and 24 mJ/rev, respectively, which are sufficient to power two sensors. In addition, the possibility is shown to supply power to five sensors by increase in piezoelectric material thickness. The effect of rolling tire temperature on the performance of the proposed PEH is also studied.     

Improving mixing performance by curved-blade static mixer

This article addresses design modification to a flat-blade static mixer to enhance mixing performance. The static mixer elements used in this work consist of four blades with curvature made to intensify turbulent-like flow, while reducing the pressure drop. The blades were mounted on a cylindrical housing with 45° rotation relative to the axial direction. The mixer assembly was used in three different arrangements of 8, 10, and 14 elements for a range of Reynolds number between 600 and 7,000. The coefficient of variance (COV) of samples was used to measure the mixing quality. The curved-blade mixer provides considerable improvement in mixing quality compared with the flat-blade mixer and comparable to the SMX mixer. Compared with the flat-blade static mixer, the new design reduces the COV by up to about 50%. This effect is more pronounced when the number of mixing elements increases. Furthermore, the friction factors for the modified mixer, obtained at a wide range of Reynolds number, were apparently smaller than those for the flat-blade, SMX, and SMV mixers. The correlation presented for the friction factor, when all mixer arrangements and aspect ratios were considered, supports the experimental data with ±15% deviation.     

Energetically consistent model of slipping and sticking frictional impacts in multibody systems

Multibody System Dynamics - A unifying slipping and sticking frictional impact model for multibody systems in contact with a frictional surface is presented. It is shown that the model can lead to...     

Evaluation of 1-dimensional nanomaterials release during electrospinning and thermogravimetric analysis

The growing research interests with engineered nanomaterials in academic laboratories and manufacturing facilities pose potential safety risks to students and workers. New nanoparticle substances, compositions, and processing approaches are developed regularly, creating new health risks which may not have been addressed previously. Accordingly, the Institute of Occupational Medicine conducted field studies at Texas A&M University (TAMU) to characterize possible particle emissions during processing and fabrication of carbon nanotubes, copper nanowires, and polymeric fibers. The nature of the monitoring work carried out at TAMU was to investigate the potential release of 1D nanomaterials to air from activities associated with synthesis, handling, thermal gravimetric analysis, and electrospinning processes, and evaluate the effectiveness of the utilized control measures. The potential nanoparticle release to air from each activity was investigated using a combination of particle detection instrumentations, coupled with standard filter-based sampling techniques. The analyses indicated that a measurable quantity of free carbon nanosphere aggregates was detected during these activities; however, no free MWCNTs or nanowires were detected. Scanning electron microscopy identified the presence of carbon nanospheres aggregates on the filters. While the control measures used at TAMU are effective in containing the nanomaterial release during processing, poor handling and occupational hygiene practices can increase the risk of employee exposure to the nanomaterials.     

Numerical study of enhancing vehicle radiator performance using different porous fin configurations and materials

A vehicle radiator is used for cooling down the hot working fluid with airflow passing over its flow passages and fins. The proper design of the radiator is very important due to space and weight limitations in automobiles. In this study, a numerical investigation has been conducted on the improvements, which can be obtained by implementing different porous fins in the radiator channels. The effects of different porous fin configurations with the same porous media volume on the heat transfer rate and pressure drop were investigated. The coefficient of performance values were presented for evaluating the overall performance. The investigated geometries included horizontal, vertical, corrugated, and wavy‐corrugated configurations. The results showed that the corrugated pattern had the best thermal performance among these geometries while the horizontal configuration presented the lowest pressure loss, even though the best overall performance belonged to wavy‐corrugated configuration. After selecting this configuration, the influence of different porous materials on the radiator performance was studied. Finally, the radiator with the optimum porous media configuration and material was compared to a conventional radiator. It was found that implementing this porous media in the radiator channels improves its overall thermal performance factor up to 237%.     

Analyse du champ électromagnétique dû à une décharge de foudre dans les domaines temporel et fréquentiel

The paper presents an analysis in the time and in the frequency domain of the electromagnetic field originated by negative lightning return strokes, calculated at ground level. The analysis is performed on the basis of the « Transmission Line » model modified by the authors, which gives results in good agreement with experimental data. The influence of several parameters which deeply affect the time waveshape and the frequency spectra of the electromagnetic field has been investigated. These parameters are : the rise time and the peak value of the lightning current pulse, its velocity of propagation and the rate of decreasing of the intensity of the current pulse propagating along the channel. The influence of other parameters such as the lightning channel height and the distance of the observation point is also analyzed. It is shown that the height of the channel does not affect practically the electromagnetic field. Two simplified expressions of the electromagnetic field used for the calculation of overvoltages induced on transmission lines are discussed in order to assess their validity limits.     

Dynamic analysis of a 6 DOF CKCM robot end-effector for dual-arm telerobot systems

In this paper, we present the dynamical analysis of a six-degree-of-freedom robot end-effector built to study telerobotic service and maintenance of NASA hardwares in space. The design of the end-effector is based on the concept of closed-kinematic chain mechanism capable of performing precise motion in a small workspace. After presenting a closed-form solution for the inverse kinematic problem, we employ the Lagrangian approach to derive a set of equations of motion for the end-effector where the generalized coordinates are selected to be the Cartesian coordinates. Computer simulation study shows that the centrifugal and Coriolis terms can be neglected fow slow motion. Effects of system parameters on the end-effector dynamics are also studied using computer simulation.