MEETING THE IT CHALLENGES OF BUSINESS The Changing Mandate for MBAs

What is the implication for business when information technology (IT) changes in the workplace without a commensurate change in the composition of business programs educating tomorrow's employees? A survey of MBA graduates forms the basis of this article on the IT skills needed in the marketplace.     

Nonlocal quasi-Newton method for solving convex variational inequalities

Conclusion In the optimization problem [f ₀(x)│h_i(x)<-0,i=1,…,l] relaxation of the functionf ₀(x)+Nh⁺(x) does not produce, as we know [6, 7], α_k=1 in Newton's method with the auxiliary problem (5), (6), whereF(x)=f _0′(x). For this reason, Newton type methods based on relaxation off ₀(x)+Nh⁺(x) are not superlinearly convergent (so-called Maratos effect). The results of this article indicate that if (F(x)=f _0′(x), then replacement of the initial optimization problem with a larger equivalent problem (7) eliminates the Maratos effect in the proposed quasi-Newton method. This result is mainly of theoretical interest, because Newton type optimization methods in the space of the variablesx ∈R ⁿ are less complex. However to the best of our knowledge, the difficulties with nonlocal convergence arising in these methods (choice of parameters, etc.) have not been fully resolved [10, 11]. The discussion of these difficulties and comparison with the proposed method fall outside the scope of the present article, which focuses on solution of variational inequalities (1), (2) for the general caseF′(x)≠F′ ^T(x). Translated from Kibernetika i Sistemnyi Analiz, No. 6, pp. 78–91, November–December, 1994.     

Large-deviation inequalities for parameter estimators in stochastic systems

Translated from Kibernetika i Sistemnyi Analiz, No. 2, pp. 95–112, March–April, 1994.     

Algebra of algorithms and Kaluzhnin's graphschemas

This research was supported under project No. 6.02.02/128-93 as part of the state scientific-technical program on future information technologies and systems by the Ukrainian State Committee, of Science and Technology.     

Components of random generation by normal subjects and patients with dysexecutive syndrome

The study presents a hypothesis on how randomness could be simulated by human subjects. Three sources of deviation from randomness are predicted: (1) the preferred application of overlearned production schemata for producing sequences of digits, (2) a wrong concept of randomness, and (3) the impossibility to monitor for redundancies of higher- than those of first-order. Deviations of random generation of digits produced by healthy subjects, patients with chronic frontal lobe damage, and patients with Parkinson's disease from random sequences produced by a computer program can be explained by the differential influence of these factors. Whereas incorrect concepts of randomness and limits on monitoring capacity distinguished all sequences produced by humans from actual random sequences, persistence on a single production strategy distinguished brain-damaged patients from controls. Random generation of digits appears to be a theoretically transparent and clinically useful test of executive function.     

Potentiation of tumour necrosis factor-mediated cell killing by VP16 on human ovarian cancer cell lines. In vitro results and clinical implications

Synergism between recombinant human tumour necrosis factor (rHuTNF) and DNA topoisomerase II inhibitor VP16 during the killing of cells has been studied in six human ovarian cancer cell lines (A2774, A2780, SW626, IGROV-1, SKOV3, Pa1) and a cervical carcinoma cell line (Me180). Studies were performed using an assay of colony formation inhibition (drug treatment for 1 h) and a growth inhibition assay (continuous exposure for 20 h). Concomitant treatment of cells with VP16+rHuTNF enhanced cell killing in all the cell lines tested--an effect observed in both short- and long-term cytotoxicity assays. This study suggests that the activity of VP16 in ovarian cancer cell lines might be enhanced by rHuTNF in in vitro models.