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21.
根据保护煤柱设计原理 ,利用微机采用垂线法留设保护煤柱的数学模型、程序流程以及得到的算例结果。利用该方法 ,只要将有关资料输入计算机 ,就能快速准确地自动计算出煤柱角点坐标、煤柱面积和压煤量。 相似文献
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BACKGROUND: The matrix metalloproteinases (MMPs) MMP2 and MMP9 play a significant role in epidermal detachment, inflammation and re-epithelialization. We have evaluated their activity in toxic epidermal necrolysis (TEN). DESIGN: The level and pattern of activity of MMP2 and MMP9 were investigated by measuring the degradation of 3H-labelled gelatin and by zymography in blister fluid from six TEN patients and compared the results with three other blistering conditions: bullous pemphigoid (n = 6), second-degree burn (n = 13) or suction blister (n = 3). RESULTS: A higher amount of MMP2 was found in TEN blister fluid with the constant presence of a significantly larger proportion of the activated forms of MMP2, a particular feature of TEN, than the other blistering diseases studied. CONCLUSION: This study emphasizes the potential role of MMP2 in the specific inflammatory reaction and reparation process in TEN skin. 相似文献
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中国第一口超千米深水钻井液技术 总被引:3,自引:1,他引:2
LW3-1-1探井位于中国南海珠江口盆地,作业水深1480m,完钻井深为3843m,地层以大套灰色泥岩和页岩为主,具有强水敏性.要求钻井液具有良好的流变性、润滑性、抑制性,良好的抗盐、抗钙、抗高温和抗低温能力,以及强的天然气水合物抑制能力。该井采用了PFMX钻井液体系,钻井周期为49d,介绍了钻井液工艺及现场应用情况。PFMX体系表现出很多油基钻井液的优点,如好的润滑性、高的钻进速率、膜效应、强的井眼稳定及页岩抑制性,解决了强水敏性地层的井壁稳定等问题,还解决了深水钻井中遇到的挑战,如低的破裂压力梯度、天然气永合物、浅层水流、深水低温等问题,满足了该区块作业需要。 相似文献
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介绍了雷达接收机中STC控制的产生背景、原理及方法,采用MATLAB语言进行仿真,重点介绍了一种基于电控衰减器作为受控部件的数字STC控制曲线的精确设计方法,并提出了雷达STC的设计和使用原则。 相似文献
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Ws/Ws rats are deficient in both mucosal- and connective tissue-type mast cells. To study the role of mast cells in active anaphylaxis, changes in vascular permeability in the trachea upon intravenous antigen challenge with Evans blue dye were examined in Ws/Ws, heterogenic Ws/+, and normal +/ + rats sensitized with the nematode Nippostrongylus brasiliensis. Antigen challenge resulted in fatal anaphylactic shock in some +/+ and Ws/+ rats, but not in Ws/Ws rats. Marked dye leakage developed within 30 min in the trachea of +/+ and Ws/+ rats, while Ws/Ws rats showed no substantial increases in the levels of vascular permeability. Ex vivo stimulation of sensitized lung fragments from +/+ animals with specific antigen induced significant releases of histamine and leukotriene (LT) C4, while sensitized Ws/Ws rat-lung fragments did not. In Ws/Ws rats, levels of nematode-specific IgE, IgG1 and IgG2a antibodies as well as levels of lung eosinophilia were not significantly different from those in +/+ rats. These results show that mast cell-deficient Ws/Ws rats fail to develop active anaphylaxis, and this is mediated probably by the lack of mast cell-derived mediators required for initiation of the reaction. 相似文献
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This study sought to determine whether persons of French-Canadian heritage in northern New England are at high risk for the lethal infantile form of Tay-Sachs disease. In order to accomplish this, death records and laboratory diagnostic records were surveyed to ascertain Tay-Sachs deaths in a cohort of 372,000 live births between 1977-1986. The proportion of the total population with French-Canadian or Jewish heritage was determined from census and birth records, and the ethnic background of Tay-Sachs cases was determined from the corresponding birth records. In 1,860 births, both parents were of Ashkenazi Jewish heritage. One of those children was diagnosed with Tay-Sachs disease. In 41,000 births, both parents were of French-Canadian heritage, and in an additional 93,000 births, one parent was of French-Canadian heritage. No cases of Tay-Sachs disease were identified in the offspring of those individuals. Approximately 14 cases (95% confidence interval 8-20) would be expected, if the gene frequency approximated that reported for individuals of Ashkenazi Jewish heritage. Based on the results of this study, routine testing for Tay-Sachs disease heterozygosity is not indicated for persons of French-Canadian heritage in northern New England. This conclusion may not necessarily be valid for persons of French-Canadian heritage residing in other states. Further studies of Tay-Sachs disease mutations and prevalence among persons of French-Canadian heritage will be important to determine possible regional variations in gene frequencies. 相似文献