四氟乙烯-全氟丙基乙烯基醚共聚物结构和性能

采用广角X射线衍射和差示扫描量热法研究了不同组成的四氟乙烯-全氟丙基乙烯基醚（TFE-PPVE)共聚物的结晶结构、结晶度和结晶熔融温度,结果发现,当共聚物中γ(PPVE)由0．48％增大到4．02％时,晶粒尺寸从87．2nm减小到22．0nm,同时结晶度和结晶熔融温度明显降低,熔体流动速率增大,尤其当γ(PPVE)大于2．5％时,增大显著。     

流沙状氟硅酸钠晶体的制备

研究了利用反应结晶法制备流沙状氟硅酸钠时工艺条件（进料酸浓度、进料方式和结晶器型式）对结晶过程的影响。结果表明：进料H2SiF6的适宜浓度为12％,且保持H2SiF6在晶体生长区过量对晶体长大有利;采用连续结晶器可制得流沙状晶体,晶体粒度分布较好。     

甘氨酸衍生物的研究进展

甘氨酸衍生物用于工业、农业和医药等诸多方面。其在工业上是作为金属离子的有效螯合剂;在农业上被用作杀虫剂、除草剂、植物生长调节剂等;甘氨酸衍生物在医药方面的应用是近年来较为活跃的研究领域,如甘氨酸衍生物可增强甲砜霉素和β-内酰胺抗生素的药效．合成抗肿瘤药物的中间体等。但在其中一些领域的研究还处在实验室阶段,有待于进一步探索。     

复杂型面及其法向等距面的数学模型

对由离散点给出的复杂型面的每一截面的型值点用大挠度三次样条连接,而各截面采用基样条函数连接,组成基样条函数和大挠度样条曲线的混合曲面,从而推导出复杂型面及其法向等距面的数学模型。     

激光引发气相化学合成Si3N4超细粉末

利用CO_2激光引发在NH_3/Si_3H_4体系中化学合成超细、高纯Si_3N_4粉末。实验研究了反应参数和反应条件,在较好的实验条件下制备出近似球形、粒径约20mm、纯度98％的无定形Si_3N_4粉末。     

Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth

Dysregulated epidermal growth factor receptor (EGFR) expression is frequently observed in non-small cell lung cancer (NSCLC) growth and metastasis. Despite recent successes in the development of tyrosine kinase inhibitors (TKIs), inevitable resistance to TKIs has led to urgent calls for novel EGFR inhibitors. Herein, we report a rational workflow used to identify novel EGFR-TKIs by combining hybrid ligand- and structure-based pharmacophore models. Three types of models were developed in this workflow, including 3D QSAR-, common feature-, and structure-based EGFR-TK domain-containing pharmacophores. A National Cancer Institute (NCI) compound dataset was adopted for multiple-stage pharmacophore-based virtual screening (PBVS) of various pharmacophore models. The six top-scoring compounds were identified through the PBVS pipeline coupled with molecular docking. Among these compounds, NSC609077 exerted a significant inhibitory effect on EGFR activity in gefitinib-resistant H1975 cells, as determined by an enzyme-linked immunosorbent assay (ELISA). Further investigations showed that NSC609077 inhibited the anchorage-dependent growth and migration of lung cancer cells. Furthermore, NSC609077 exerted a suppressive effect on the EGFR/PI3K/AKT pathway in H1975 cells. In conclusion, these findings suggest that hybrid virtual screening may accelerate the development of targeted drugs for lung cancer treatment.     

Continuous aligned poly(meta‐phenylene isophthalamide) fibers via stable jet electrospinning

Continuous aligned poly(meta‐phenylene isophthalamide) (PMIA) fibers are first fabricated by Stable Jet Electrospinning (SJES) with a collection distance of 15 cm. The unfolded length of every single fiber is calculated to be several hundred to several thousand meters. Morphology analysis by field emission scanning electron microscopy (FE‐SEM) shows that these fibers are well arranged and uniformly distributed and their average fiber diameters decrease gradually with increasing collection speed. The effects of ambient temperature and humidity on the duration of stable jet are also discussed. Moderate temperatures and humidity are preferred for fabricating PMIA fibers with ultra‐long size. Besides, the changes of the thermal and crystalline properties of PMIA fibers are also investigated. The significant decline in crystallinity should be responsible for its decreased thermal property. Further improvements to its thermal and crystalline performance must be given consideration in future applications. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 43690.     

T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death

T315, an integrin-linked kinase (ILK) inhibitor, has been shown to suppress the proliferation of breast cancer, stomach cancer and chronic lymphocytic leukemia cells. Here we demonstrate that T315 decreases cell viability of acute myeloid leukemia (AML) cell lines (HL-60 and THP-1) and primary leukemia cells from AML patients in a dose-responsive manner. Normal human bone marrow cells are less sensitive than leukemia cells to T315. T315 down regulates protein kinase B (Akt) and p-Akt and induces caspase activation, poly-ADP-ribose polymerase (PARP) cleavage, apoptosis and autophagy through an ILK-independent manner. Interestingly, pretreatment with autophagy inhibitors rescues cells from apoptosis and concomitant PARP cleavage, which implicates a key role of autophagic cell death in T315-mediated cytotoxicity. T315 also demonstrates efficacy in vivo, suppressing the growth of THP-1 xenograft tumors in athymic nude mice when administered intraperitoneally. This study shows that autophagic cell death and apoptosis cooperatively contribute to the anticancer activity of T315 in AML cells. In conclusion, the complementary roles of apoptotic and autophagic cell death should be considered in the future assessment of the translational value of T315 in AML therapy.     

氯碱化工设备防腐蚀技术的应用

为了提高氯碱设备使用寿命,防止其过早腐蚀失效,可采用聚合物涂料防腐蚀技术。介绍了几种聚合物涂料在氯碱设备制造和维修中成功应用的实例。