Novel bone substitutes such as highly porous ceramic scaffolds can serve as platforms for delivering active molecules. A common problem is to control the release of the drug, therefore, it is beneficial to use a drug-functionalized polymer coating. In this study, β-tricalcium phosphate-based porous scaffolds were obtained and coated with diclofenac-functionalized biopolymer – poly(3-hydroxyoctanoate) – P(3HO). To the best of our knowledge, studies using P(3HO) as a component in ceramic-polymer based drug delivery system for bone tissue regeneration have not yet been reported. Presented materials were comprehensively investigated by various techniques such as powder X-ray diffraction, scanning electron microscopy with energy dispersive spectroscopy, hydrostatic weighing and compression tests, pH and ionic conductivity measurements, high-performance liquid chromatography and in vitro cytotoxicity studies. The obtained diclofenac-loaded composite was not only characterised by controlled and sustained drug release, but also possessed improved mechanical properties. Moreover, the precipitation of apatite-like forms on its surface was observed after incubation in simulated body fluid, which indicates its bioactive potential. After 24 hours no cytotoxic effect on MC3T3-E1 mouse preosteoblastic cells was confirmed using indirect cytotoxicity studies. Thus, this promising multifunctional composite scaffold can be a promising candidate as an anti-inflammatory drug-delivery system in bone tissue engineering. 相似文献
Circular Economy (CE) is one of the approaches which are intensively developed and tested in different areas of industry and services. The aim of this solution is to use many kinds of resources in a closed flow and to achieve as a small amount of waste as it is possible.
One of the potential areas of using CE is Radio Frequency Identification (RFID). In RFID systems tags are utilized in various forms. This paper addresses investigation of a recycling process of RFID tags. Different attachment methods of these tags were tested and then, a recycling procedure was prepared based on the obtained results in which adhesives are recommended to be used as an attaching material between a tag and an identified object. The mentioned procedure was evaluated with using paper-face RFID tags. It was confirmed applicability of the proposed solution. Moreover, the conducted research revealed that an adhesion force of the adhesive layers in the prepared RFID tags decreased in the most extent during the first recycling cycle. It was found that in order to preserve a high adhesion force of these layers it is suggested to place the tags on a clean surface. 相似文献
We consider local time evolution given by spontaneous emission in the system of independent two-level atoms. It is shown that all classically correlated initial states are driven into the states with transient non-zero quantum discord. Thus local creation of genuine quantum correlations can be observed in a simple physical system of non-interacting atoms which are not completely isolated from the environment. 相似文献
High-entropy, iron-containing, garnet-structured oxides with (Dy,Er,Gd,Ho,Y)3Fe5O12 and (Dy,Gd,Ho,Sm,Y)3Fe5O12 compositions are synthesized for the first time. A modified Pechini method followed by calcination at 700 °C and sintering at 1300 °C enables obtaining single-phase, homogenous materials of cubic structure with Ia-3d symmetry. High-temperature in-situ X-ray diffraction studies show excellent phase stability of the garnets, as well as moderate thermal expansion coefficient, ca. 11·10?6 K-1 in 25?1000 °C temperature range. Raman spectroscopy measurements indicate the presence of local distortion of structural polyhedra, likely associated with the high-entropy effect. The collected Mossbauer spectra confirm distorted character of the lattice. Influenced by the presence of Fe3+ in locally distorted octahedra and tetrahedra, the electrical conduction at low temperatures of both oxides remains much lower comparing to Y3Fe5O12 (yttrium iron garnet - YIG), as well as to other rare-earth garnets up to 600 °C, where it reaches value similar to YIG. 相似文献
Pattern Analysis and Applications - One of the crucial problems of designing a classifier ensemble is the proper choice of the base classifier line-up. Basically, such an ensemble is formed on the... 相似文献
The dark current of near-room-temperature long-wavelength heterojunction photodiodes was studied. The dark current of the
devices is much greater than that calculated from the Auger generation mechanisms. A model of trap- assisted tunneling via
traps located at dislocation cores is proposed as the mechanism of enhanced thermal generation of charge carriers in reverse-biased
diodes. Field-induced reduction of trap activation energies can increase thermal generation and create conditions for tunneling
currents. The model qualitatively explains experimental current−voltage characteristics of the diodes assuming a dislocation
density of approximately 108 cm−2 at the graded gap interface between absorber and contact regions of the photodiode. 相似文献