Domain-Driven, Actionable Knowledge Discovery

Data mining increasingly faces complex challenges in the real-life world of business problems and needs. The gap between business expectations and R&D results in this area involves key aspects of the field, such as methodologies, targeted problems, pattern interestingness, and infrastructure support. Both researchers and practitioners are realizing the importance of domain knowledge to close this gap and develop actionable knowledge for real user needs.     

Impact of dimension uncertainty and model calibration on sewer system assessment.

Assessments of sewer performance are usually based on a single computation of CSO (combined sewer overflow) volumes using a time series of rainfall as system loads. A shortcoming of this method is that uncertainties in knowledge of sewer system dimensions are not taken into account. Moreover, sewer models are rarely calibrated. This paper presents the impacts of database errors and model calibration on return periods of calculated CSO volumes. The impact of uncertainties is illustrated with two examples. Variability of calculated CSO volumes is estimated using Monte Carlo simulations. The results show that calculated CSO volumes vary considerably due to database errors, especially uncertain dimensions of the catchment area. Furthermore, event-based calibration of a sewer model does not result in more reliable predictions because the calibrated parameters have low portability. However, it enables removal of database errors harmonising model predictions and 'reality'.     

Phylogenetic scanning: a computer-assisted algorithm for mapping gene conversions and other recombinational events

An algorithm, 'phylogenetic scanning', is described for mapping gene conversion events where comparative DNA sequence data are available from different species. In this algorithm, sets of hypothetical phylogenetic trees are constructed that describe possible sequence relationships due to gene conversions in different species lineages; these trees are then evaluated by the principle of parsimony at intervals in the sequence alignment. When used to map gene conversion events that occurred between the pair of gamma-globin genes of higher primates, the algorithm gives results nearly identical to those obtained using a tedious manual approach. Suggestions are also provided for adaptation of this procedure to the analysis of other recombination events.     

Some electron microscope observations of longitudinal splitting from surface flaws in Kevlar 29

Journal of Materials Science Letters -     

Materials technology for aerospace applications

Modern helicopter design depends on the successful combination of materials to fulfil a very wide range of critical functions. In the past few years demands from the aerospace industry have caused considerable enhancement in the favourable properties of both polymer based materials and metals. These are discussed in connection with the progressive technical evolution of helicopters and other advanced technological products from the Westland Group.     

Optical imaging of anatomical maps derived from magnetic resonanceimages using time-independent optical sources

Presents a model suitable for computing images of absorption cross sections of thick tissue structures illuminated at near infrared (NIR) wavelengths from tomographic projection data. Image reconstruction is accomplished by solving a system of linear equations derived from transport theory. Reconstruction results using different algebraic solvers are shown for anatomical maps of the breast, derived from magnetic resonance imaging data, containing two simulated pathologies, in which case qualitatively good reconstructions were obtained. Evaluation of magnetic resonance (MR) data to optimize NIR optical tomographic imaging methods and to assess the feasibility of a combined MR-optical measurement scheme is discussed     

The influence of trigger configurations and laminate lay-up on the failure mode of composite crush cylinders

In this paper the results are presented of a test program on the energy absorption of composite cylinders loaded in compression. The influence of the laminate lay-up and of the trigger configuration were determined. Two different failure modes for the different laminates and triggers were observed: a splaying mode and a fragmentation mode. The splaying mode is more efficient in absorbing energy. The failure mode did not change during the crushing process.     

Ankle performance after ankle fracture: a randomized study of early mobilization

Low concentrations of some neutral dipeptides, such as L-Ala-L-Ala, rapidly disrupt rat liver lysosomes. The phenomenon has been attributed to an osmotic imbalance generated by the production of amino acids in the lysosome by lysosomal dipeptidase activity. This hypothesis is challenged by testing several pairs of dipeptides available in both D- and L-forms and a range of dipeptides whose susceptibility to lysosomal dipeptidase activity is known. A good correlation was found between the lytic ability of dipeptides and their capacity to cross the lysosome membrane and be hydrolysed by lysosomal dipeptidase. The osmotic-imbalance hypothesis is critically evaluated in the light of the results and of recent information concerning the carrier-mediated transport of amino acids and dipeptides across the lysosome membrane. It is concluded that intralysosomal generation of amino acids remains the most plausible explanation of the lytic activity of dipeptides, and that the dipeptide porter(s) in the lysosome membrane must have higher Km than the amino acid porters.