机械合金化Zr-Al-Ni-Cu-Ag非晶合金的晶化行为

研究了机械合金化非晶态Zr65Al7.5Ni10Cu7.5Ag10合金的晶化过程，由于存在扩散不均匀区，机械合金化非晶合金在深过冷液相区的退火组织不同于快淬合金，在深过冷液相区退火，析出二十面体准晶相及一些知相：在靠近第一个放热峰的温度退火，近出Zr2Cu相：第二个放热峰对应残余非晶相及准晶相向Zr2Ni,Zr2-Al3的转变。     

A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein

We have identified three yeast genes, KES1, HES1 and OSH1, whose products show homology to the human oxysterol binding protein (OSBP). Mutations in these genes resulted in pleiotropic sterol-related phenotypes. These include tryptophan-transport defects and nystatin resistance, shown by double and triple mutants. In addition, mutant combinations showed small but apparently cumulative reductions in membrane ergosterol levels. The three yeast genes are also functionally related as overexpression of HES1 or KES1 alleviated the tryptophan-transport defect in kes1Δ or osh1Δ mutants, respectively. Our study implicates this new yeast gene family in ergosterol synthesis and provides comparative evidence of a role for human OSBP in cholesterol synthesis.     

Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy

Although hapten immune responses have been intensively studied in the mouse, very little is known about hapten determinants involved in human allergic reactions. Penicillins, as chemically reactive compounds of low molecular weight, constitute typical examples of hapten allergens for humans. Penicillins become immunogenic only after covalent binding to carrier proteins and in this form frequently induced IgE-mediated allergic reactions in patients subjected to antibiotic treatment. However, our previous data strongly indicated that penicillins also form part of the epitopes contacting the antigen receptors of beta lactam-specific T cells in allergic individuals. We have therefore investigated the molecular constraints involved in the T cell immune response to penicillin G (Pen G). Designer peptides containing a DRB1*0401-binding motif and covalently modified with Pen G via a lysine epsilon-amino group were found to induce proliferation of Pen G-specific T cell clones. A precise positioning of the hapten molecule on the peptide backbone was required for optimal T cell recognition. Furthermore, we extended these observations from our designer peptides to show that a peptide sequence derived from a natural DRB1*1101-binding peptide modified in vitro with Pen G, also acquired antigenic properties. Our data for the first time provide insight into the manner in which allergenic haptens are recognized by human T cells involved in allergic reactions to drugs and suggest possible mechanisms leading to the onset of these adverse immune responses.     

Ti-23Al-14Nb-3V合金氩弧焊接头的显微组织及其力学性能

研究了预热对Ｔｉ－２３Ａｌ－１４Ｎｂ－３Ｖ合金焊接性，特别是对消除氩弧焊冷裂纹的作用以及对接头显微组织和力学性能的影响。结果表明，焊前预热可有效降低该合金的冷裂倾向。经预热处理后，焊缝区的结晶层状线消失，热影响区的硬度峰得到缓和，整个焊缝的显微硬度分布趋于均匀，但焊缝区的枝晶发生粗化，热影响区有所扩大。焊件接头的拉伸试验表明，预热可使焊缝区的接头强度系数增加，但无论预热与否，接头强度均低于母材强度，且不显示宏观塑性。     

昌平区水资源情势分析及应对措施

水资源供需矛盾、水污染、地下水超采是当前及今后一段时间昌平区水资源面临的突出问题.继续坚持开源、节流、治污等措施,完善水管理体制,提高水资源综合管理水平,建设循环水务模式,是实现水资源可持续利用的重要措施.     

活性污泥生物相对污水处理运行的指导作用

污水处理系统处理效果的好坏都与污水处理系统中组成活性污泥的微生物种类、数量及其代谢活力有关,本文从活性污泥结构、微生物种类、数量及活性等方面分析了污泥生物相与运行状态的相互关系.说明了可通过对污水处理系统的生物相观察了解处理效果及运行状况,也可通过对污泥生物相观察发现处理系统环境的变化,及时调整运行环境,预防污水处理系统的运行中的异常情况发生.     

浅谈南水北调工程中招标代理机构的自身建设

在市场经济条件下,随着水利工程建设市场的不断规范和完善,招标代理机构如何在市场竞争中开展招标代理业务,其自身建设就显得尤为重要。现结合南水北调工程实际,提出了招标代理机构应从法律意识、诚实信用、专业特长、激励机制和沟通协调等5个方面加强自身建设,以便能在南水北调工程建设中更好地发挥作用。     

基于S-CDMA的HFC上行信道接入协议性能仿真分析

讨论了基于S－CDMA的HFC网上行信道的高效接入协议－SAMA，提出了双信道接入机制的工作原理，并对系统性能进行了分析与计算机仿真，得到一些有意义的结论。     

中国香港电信盈科公司近期经营业绩分析

中国香港电信与盈科数码动力有限公司合并以后更名为电信盈科。它由一家以技术为主的电信公司转型为亚太地区、特别是两岸三地的商界及个人客户提供服务的综合通信服务供应商，主要提供电话服务、互联网、商企电贸服务、数据中心、客户联络中心、环球通信服务和基建业务。分析了2001-2002年上半年其电信、商企电贸、基建以及与Telstra结盟等业务市场的经营情况。