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111.
Gilad Nahari Dr. Ori Braitbard Dr. Liraz Larush Prof. Jacob Hochman Prof. Edit Y. Tshuva 《ChemMedChem》2021,16(1):108-112
Abstract : Orally administered anticancer drugs facilitate treatment, but the acidic conditions in the stomach often challenge their availability. PhenolaTi is a TiIV-based nontoxic anticancer drug with marked in-vivo efficacy. We report that nanoformulation protects phenolaTi from decomposition in stomach-like conditions. This is evidenced by similar NMR characteristics and similar in-vitro cytotoxicity toward murine (CT-26) and human (HT-29) colon cancer cells before and after incubation of nanoformulated phenolaTi (phenolaTi-F) at pH 2, unlike results with the unformulated form of the complex. Furthermore, administration of phenolaTi-F in animal drinking water revealed a notable inhibition of tumor growth in Balb/c and immune-deficient (Nude) mice inoculated with CT-26 and HT-29 cells, respectively. In-vivo efficacy was at least similar to that of the corresponding intraperitoneal treatment with phenolaTi-F and the clinically employed oral drug, capecitabine. No body weight loss or clinical signs of toxicity were evident in the phenolaTi-F-treated animals. These findings demonstrate a new convenient mode of cancer treatment through oral administration by safe titanium-based drugs. 相似文献
112.
Enrichment of fruits with nutraceutical components for increased nutritional- and health-beneficial qualities is a major goal for the food processing industries. In the present study, we have investigated the benefits of an osmotic infusion process by means of which a fructo-oligosacharide (Nutraflora?) was used to partially substitute sucrose in the infusion medium. Fruits such as sweet cherry, mango and blueberry could be subjected to osmotic infusion, resulting in improved quality characteristics. During infusion, loss of anthocyanins from blueberry and cherry fruits was observed, but this did not reduce the visual appeal of infused fruits. In conjunction with Nutraflora, fruits could be infused with soy lecithin (phospholipids) and excised mango assimilated significant amounts of phospholipids. Structurally, Nutraflora infused cherry fruits showed preservation of tissue structure similar to that in a fresh fruit. As well, Nutraflora infused fruits showed higher levels of soluble and insoluble solids content. DPPH radical scavenging activity of fresh and infused fruit extracts did not differ significantly suggesting that the antioxidant activity of infused fruits is not impaired by the process. Thus, infusion of fruits with desired components having health benefits can provide nutritionally superior fruit products with improved functionality. 相似文献
113.
Chung‐Yung Lee Jacob Yeuk‐Lung Ho Man‐Chun Tseng Hoi‐Sing Kwok 《Journal of the Society for Information Display》2013,21(9):407-410
A new type of nanostructured alignment surface is proposed and demonstrated. As in previous nanostructured alignment surfaces, a large pretilt angle of near 45° can be produced reliably. Moreover, this new structure is fabricated with a mask, and there is no randomness involved. The uniformity and anchoring properties of this new surface have been measured to be of excellent quality. 相似文献
114.
In this paper, we demonstrated the processing of Li7La3Zr0.5Nb0.5Ta0.5Hf0.5O12 (LLZNTH) high-entropy Li–garnet with promising properties for lithium batteries. We first synthesized the LLZNTH Li–garnet powders which have a single cubic garnet phase (space group: ; No. 230) without any secondary phases as well as uniform elements distributions. The prepared powders were further densified to a relative density of ∼94% with well-crystallized grains and good contact with the neighboring grains. Minimal grain growth can be observed in the sintering time range from 8 to 20 h, which is likely due to the sluggish effects of high-entropy compounds. The sample also maintains the cubic garnet phase along with uniform elements distribution after sintering. Electrochemical characterizations indicate that the densified sample has an adequate ionic conductivity of 4.67 × 10−4 S cm−1 at room temperature, a low activation energy of 0.25 eV, and a low electronic conductivity in the order of 10−8 S cm−1. The significance of designing high-entropy electrolyte is further discussed. 相似文献
115.
Kyle J. Sommers Brian S. Bentley Dr. Robert G. Carden Savannah J. Post Ryan A. Allen Renee C. Kontos Jacob W. Black Prof. William M. Wuest Prof. Kevin P. C. Minbiole 《ChemMedChem》2021,16(3):467-471
Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs. 相似文献
116.
Silvia Bierlich Timmy Reimann Frauke Gellersen Arne F. Jacob Jörg Töpfer 《Journal of the European Ceramic Society》2019,39(10):3077-3081
Sc3+ substituted M-type ferrites are effective microwave magnetic materials with a ferromagnetic resonance frequency in the range of 20 GHz–50 GHz. We report on the fabrication of oriented ferrite thick films as microwave components for application in the Ka-band at 30 GHz. Films of BaFe11.5.Sc0.5O19 were prepared by screen-printing on alumina substrates, drying in an external magnetic field, and sintering at 900 °C. Low-temperature sintering is achieved through use of a mixed BBSZ/CuO sintering aid. A strong anisotropy of the sintered ferrite films is revealed by XRD analysis. Microwave properties of the films were determined in a coplanar waveguide setup. The ferromagnetic resonance frequency of the films is at 30 GHz and the textured films possess good nonreciprocal properties which scale with film thickness. The films were tested in a Y-junction circulator, and represent promising materials for self-biased microwave components fabricated in thick film technology. 相似文献
117.
Nielsen Jacob Obitsø Christiansen Thomas Lundin Pantleon Karen 《Metallurgical and Materials Transactions A》2020,51(9):4880-4889
Metallurgical and Materials Transactions A - Fe-C coatings with a high amount of carbon were electrodeposited from an iron-sulfate electrolyte. Citric acid as an additive in the electrolyte not... 相似文献
118.
119.
Wireless Networks - Device to device (D2D) communication that provides high data rate proximity based direct communication between users, along with simultaneous wireless information and power... 相似文献