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31.
Nina Krako Jakovljevic Kasja Pavlovic Aleksandra Jotic Katarina Lalic Milica Stoiljkovic Ljiljana Lukic Tanja Milicic Marija Macesic Jelena Stanarcic Gajovic Nebojsa M. Lalic 《International journal of molecular sciences》2021,22(12)
Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often preceded by insulin resistance (IR), which underlies the inability of tissues to respond to insulin and leads to disturbed metabolic homeostasis. Mitochondria, as a central player in the cellular energy metabolism, are involved in the mechanisms of IR and T2D. Mitochondrial function is affected by insulin resistance in different tissues, among which skeletal muscle and liver have the highest impact on whole-body glucose homeostasis. This review focuses on human studies that assess mitochondrial function in liver, muscle and blood cells in the context of T2D. Furthermore, different interventions targeting mitochondria in IR and T2D are listed, with a selection of studies using respirometry as a measure of mitochondrial function, for better data comparison. Altogether, mitochondrial respiratory capacity appears to be a metabolic indicator since it decreases as the disease progresses but increases after lifestyle (exercise) and pharmacological interventions, together with the improvement in metabolic health. Finally, novel therapeutics developed to target mitochondria have potential for a more integrative therapeutic approach, treating both causative and secondary defects of diabetes. 相似文献
32.
Cognitive radio technology necessitates accurate and timely sensing of the primary users’ activity on the chosen set of channels. If sensing error is unacceptably high, we can reduce the number of working channels so as to improve the channels-vs.-sensing nodes ratio, and undertake differential or split sensing in which subsets of sensing nodes target idle and active channels, respectively. The paper presents a probabilistic analysis of the sensing process, including the split sensing policy, and investigates the range of values in which such, incomplete sensing is capable of maintaining an accurate view of the status of the working channel set. 相似文献
33.
34.
Riccardo Bernardini Jelena Kova<cević 《Multidimensional Systems and Signal Processing》1996,7(3-4):331-369
We present a new method for constructing local orthogonal bases, both in continuous and discrete time. All basis functions are obtained from a single prototype window, and there exists a fast algorithm for implementation. The approach is very general and can handle a large variety of cases interesting for applications, such as audio and image coding. 相似文献
35.
Fostering scholarly productivity through academic and internship research training environments. 总被引:1,自引:0,他引:1
Szymanski Dawn M.; Ozegovic Jelena Jovanovic; Phillips Julia C.; Briggs-Phillips Melissa 《Canadian Metallurgical Quarterly》2007,1(2):135
How can training programs foster counseling and clinical psychologists' scholarly productivity? This study examined the impact of academic and internship research training environments (RTEs) on the scholarly activity of 223 early career professionals. Results supported the construct validity of the Internship Research Training Environment scale through cross-validation and confirmatory factor analysis. Findings revealed differences in perceptions of the internship RTE and scholarly productivity as a function of academic training philosophy and internship training philosophy. Finally, results suggested that academic and internship RTEs could influence research interest and scholarly productivity indirectly by enhancing research self-efficacy and research outcome expectations. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
36.
Acenaphthylene, fluoranthene and their congeners are compounds that, in view of their chemical and physical properties, belong among benzenoid hydrocarbons. However, because of the presence of a five-membered ring, in all chemical-graph-theoretical considerations of benzenoid systems, these species have been disregarded. Continuing our recent studies of the title compounds, we report here on a peculiar characteristic of the pattern of their cyclic conjugation, named “the phenyl-cyclopentadienyl rule” (PCP rule): if a benzene ring is connected with the (unique) five-membered ring by exactly one carbon-carbon bond (which we refer to as a PCP constellation), then the cyclic conjugation in the five-membered ring significantly increases. If there are several PCP constellations, then the intensity of cyclic conjugation is additionally increased. 相似文献
37.
Nikolic Maria Vesna Labus Nebojsa J. Pavlovic Vera P. Markovic Smilja Lukovic Miloljub D. Tadic Nenad B. Vujancevic Jelena D. Vlahovic Branislav Pavlovic Vladimir B. 《Journal of Electroceramics》2020,45(4):135-147
Journal of Electroceramics - Nanocrystalline Zn2SnO4/SnO2 powder was obtained by a solid state reaction of ZnO and SnO2 nanopowders mixed in the molar ratio 1:1. The phase composition of the... 相似文献
38.
Vera P. Pavlović Jelena D. Vujančević Pavle Mašković Jovana Ćirković Jelena M. Papan Darko Kosanović Miroslav D. Dramićanin Predrag B. Petrović Branislav Vlahović Vladimir B. Pavlović 《Journal of the American Ceramic Society》2019,102(12):7735-7745
Titanium dioxide is a photocatalyst, known not only for its ability to oxidize organic contaminants, but also for its antimicrobial properties. In this article, significant enhancement of the antimicrobial activity of TiO2 (up to 32 times) was demonstrated after its activation by ball milling. The antimicrobial activity was analyzed for one fungal and 13 bacterial ATCC strains using the microdilution method and recording the minimum inhibitory concentration (MIC) values. In order to further investigate the correlation between the mechanical activation of TiO2 and its antimicrobial activity, the structure, morphology and phase composition of the material were studied by means of Electron Microscopy, X-ray diffraction and nitrogen adsorption-desorption measurements. UV-Vis diffuse reflectance spectra were recorded and the Kubelka-Munk function was applied to convert reflectance into the equivalent band gap energy (Eg) and, consequently, to investigate changes in the Eg value. X-ray photoelectron spectroscopy was used to analyze the influence of mechanical activation on the Ti 2p and O 1s spectra. The presented results are expected to enable the development of more sustainable and effective advanced TiO2-based materials with antimicrobial properties that could be used in numerous green technology applications. 相似文献
39.
Dr. Jelena Melesina Conrad V. Simoben Lucas Praetorius Emre F. Bülbül Dr. Dina Robaa Prof. Dr. Wolfgang Sippl 《ChemMedChem》2021,16(9):1336-1359
This review classifies drug-design strategies successfully implemented in the development of histone deacetylase (HDAC) inhibitors, which have many applications including cancer treatment. Our focus is on especially demanded selective HDAC inhibitors and their structure-activity relationships in relation to corresponding protein structures. The main part of the paper is divided into six subsections each narrating how optimization of one of six structural features can influence inhibitor selectivity. It starts with the impact of the zinc binding group on selectivity, continues with the optimization of the linker placed in the substrate binding tunnel as well as the adjustment of the cap group interacting with the surface of the protein, and ends with the addition of groups targeting class-specific sub-pockets: the side-pocket-, lower-pocket- and foot-pocket-targeting groups. The review is rounded off with a conclusion and an outlook on the future of HDAC inhibitor design. 相似文献
40.
Alisa Šehić Jelena Vasiljević Andrej Demšar Mirjam Leskovšek Vili Bukošek Jožef Medved Marija Čolović Ivan Jerman Barbara Simončič 《应用聚合物科学杂志》2019,136(5):47007
Polyamide 6 (PA6) composite filament yarns were produced by the simultaneous incorporation of melamine cyanurate (MeCy) with multiwalled carbon nanotubes (CNTs) and carbon black (CB) into a composite matrix in a melt-spinning process. The results show that the simultaneous incorporation of MeCy with CNTs or CB additives provided filaments with a uniform black color. Tensile analysis confirmed that a reinforcing effect was achieved when CB was used, whereas the CNTs induced a reducing effect on the filament tenacity. With regard to the burning behavior, the flame-retardant action of MeCy was preserved in the presence of CB but was significantly hindered when used in combination with CNTs. These results indicate that the mixture of MeCy and CB was much more compatible for the production of reinforced PA6 composite filaments with increased thermal stability and improved flame retardancy over those of the MeCy and CNTs. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47007. 相似文献