The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance

Ischemic conditioning and exercise have been suggested for protecting against brain ischemia-reperfusion injury. However, the endogenous protective mechanisms stimulated by these interventions remain unclear. Here, in a comprehensive translational study, we investigated the protective role of extracellular vesicles (EVs) released after remote ischemic conditioning (RIC), blood flow restricted resistance exercise (BFRRE), or high-load resistance exercise (HLRE). Blood samples were collected from human participants before and at serial time points after intervention. RIC and BFRRE plasma EVs released early after stimulation improved viability of endothelial cells subjected to oxygen-glucose deprivation. Furthermore, post-RIC EVs accumulated in the ischemic area of a stroke mouse model, and a mean decrease in infarct volume was observed for post-RIC EVs, although not reaching statistical significance. Thus, circulating EVs induced by RIC and BFRRE can mediate protection, but the in vivo and translational effects of conditioned EVs require further experimental verification.     

Effect of Mn Modification on the Corrosion Susceptibility of Mg–Mn Alloys by Magnesium Scrap

The microstructure and anti-corrosion behavior of Mg–Mn alloys by magnesium scrap have been investigated in this study.The results show that the size of the Fe-rich particles in magnesium scrap decreases but the quantity increases with the Mn addition.Although the presence of Mn-containing Fe-rich particles with unique symbiotic structure can eff ectively weaken the micro-galvanic corrosion,the presence of more free Fe(Fe-rich particles) does not necessarily lead to severe corrosion of the alloy.The corrosion susceptibility of Mg–Mn–Fe alloy primarily depends on the solubility of iron in the Mg matrix,while it can be significantly reduced by suitable Mn addition.Besides,the tolerance limit of the Fe impurity can be expressed as Fe_(max) = 0.0083 Mn(relative to the iron solubility).Only when the Fe/Mn ratio is below 0.0083 can the alloy have excellent corrosion resistance,with the corrosion rate changing in the scope of 0.38 ± 0.09 to 0.54 ± 0.15 mg/cm~2 day and i_(corr) from 3 to 9 × 10~(–4) A/cm~2.     

An experimental study on the choked flow characteristics of CO2 pipelines in various phases

High pressure pipeline transportation has been an established technology for economically transporting large amounts of CO_2. However, there are still issues and associated risks that have to be effectively addressed and adequately understood. It is well known that a strong Joule-Thomson Cooling effect can occur when pressurized CO_2 flows through a choke valve. Thus, to investigate the choking characteristics especially the temperature drop of high pressure CO_2, a new laboratory scale experimental setup(total length of 14.85 m and the inner diameter of 15 mm) was constructed. Steady choked flow and transient choked flow tests were carried out respectively for pressurized CO_2 in various initial phases. The phase transitions and temperature drop characteristics were then studied following the choked flow and the results show that the phase transitions in steady choked flow differs significantly from that in transient choked flow. For transient choked flow of various initial phases, all the flows downstream would transfer from single phase to gas–liquid two-phase flow. Furthermore, the effect of water on transient choked flow of supercritical CO_2 pipeline was investigated, and the phenomena of solid particles deposition was captured which was paramount importance of ensuring the safety operation of CO_2 pipelines when throttling by the choke valves.     

现代建筑设计理念在工业建筑设计中的运用

工业建筑设计要遵循现代建筑设计理念,昆明光电子产业基地项目设计,充分体现大工业集约化、以人为本、可持续发展、保护生态的建筑本质;强调由内到外的理性构成、组合,应用新技术、新材料创造简捷明快的几何形体,体现现代工业建筑时代气息。     

基于DDS的复杂信号模拟设计

随着通信技术的不断发展,信号复杂程度越来越高.本文借助软件无线电的思想,以现场可编程逻辑门阵列(FPGA)和直接数字频率合成(DDS)为中心,构成通用的硬件平台,通过更换软件的方法模拟各种复杂信号.采用该方案可实现信号模拟,且电路简单易于实现.最后,本文提供了脉冲压缩雷达(PCR)信号模拟的硬件设计.实际测试结果表明,本文给出的设计方法合理有效,有较高的实用价值.     

基于PT2262/PT2272的机器人遥控系统的设计

本文通过对PT2262/PT2272工作原理的分析,结合凌阳SPCE061A单片机提出了一种机器人遥控系统.电路易于实现、性价比高,所涉及的电路及参数均经过测试,可广泛使用于从玩具机器人到科学研究机器人中.实际应用表明,本文给出的设计方法合理有效,有效遥控距离长,具有较高的实用价值.     

基于OSPF的ASON路由的一种加密方案

自动交换光网络(ASON)控制协议采用通用多协议标签交换(GMPLS)控制协议族,其路由部分主要为开放式最短路径优先(OSPF)协议.文章分析了OSPF协议加密措施存在的安全隐患,并对现有的加密方案进行了改进.针对OSPF协议的安全模式,提出了一种可以应用于ASON中路由技术的新的安全性方案.基于数论算法,实现S盒动态调整,通过动态产生的子密钥,在迭代过程中对分组进行加密.     

一种柔性染料敏化太阳能电池的初步研究

染料敏化太阳能电池(DSSC)与商用硅电池相比,由于具有转化效率较高、制作成本低等一系列优点,近年来已受到人们的广泛关注.简要介绍了DSSC太阳能电池的结构和基本原理,重点分析了DSSC太阳能电池的关键组成和影响光电转化效率的因素.采用胶带涂覆法在柔性ITO衬底上制备了多孔纳米TiO2薄膜,通过给其配置相应的染料和电解...     

基于CAMAC总线的交替式数据采集及实时监控系统研究

进行了一种称为交替式数据采集及实时监控系统的研究。该系统不仅能实现以较高频率进行任意时间的数据采集,还能在放电过程中以图形方式实时显示等离子体的各种参数供实验人员在线分析及控制。     

三元共聚聚酰亚胺纤维的制备

针对均苯四甲酸二酐和4,4′-二氨基二苯醚体系两步法制备的聚酰亚胺(PI)纤维强度比较偏低的问题,加入刚性单体对苯二胺,在N-甲基吡咯烷酮中进行三元共聚得到聚酰胺酸(PAA),选用水和乙醇的混合溶液为凝固浴通过干湿法纺制出PAA纤维。对PAA纤维进行不同倍数的拉伸,然后通过优化酰亚胺化条件制得了致密的PI纤维,处理温度在400℃时,其强度和模量可分别达到4．29 cN/dtex和389 cN/dtex。