Permeation of Zidovudine and Probenecid from Oily Bases Containing Alcohols Through Rat Skin

Permeation of zidovudine (3'-azido-3'-deoxythymidine, AZT) and probenecid from oily bases containing an alcohol through rat skin was examined. Isopropyl myristate (IPM), as an oily vehicle, showed a penetration enhancing effect for AZT and probenecid. Ethanol, n-propanol, and n-butanol were used as additives in IPM and were examined for their own permeation and the enhancing effect on the permeation of AZT and probenecid. The skin permeation of AZT and probenecid from IPM was enhanced by addition of the alcohol in IPM. The degree of the enhancement was decreased with increasing lipophilicity of the alcohol used. me permeation rate of the drug from those systems was shown to be governed by penetration-enhancing effects of the oily base and alcohol, and the penetration of the alcohol itself through the skin.     

结构陶瓷的高温疲劳强度衰减理论

提出了陶瓷材料疲劳强度衰减理论并由此导出了各种疲劳关系式。建立了疲劳基本方程ｄσ＿ｒ／ｄ＿ｉ＝一Ａσ（ｔ）￣ｎｔ￣（－ｍ），得出了疲劳寿命公式Ｔ＝Ｍ（σ＿０－σ）／Ａσ￣ｎ（静疲劳时Ｍ＝１，连续增载疲劳时Ｍ＝ｎ＋１，循环疲劳时Ｍ＝（ｎ＋１）／（１＋Ｒ＋Ｒ￣２＋……＋Ｒ￣ｎ），逐级加载时，并导出不同疲劳方式下疲劳寿命间的关系。同时，用多种Ｓｉ＿３Ｎ＿４材料在高温中作了论证试验，结果与理论一致。     

A neural network-based power system stabilizer using power flowcharacteristics

A neural network-based power system stabilizer (neuro-PSS) is designed for a generator connected to a multi-machine power system utilizing the nonlinear power flow dynamics. The use of power flow dynamics provides a PSS for a wide range of operation with reduced size neural networks. The neuro-PSS consists of two neural networks: neuro-identifier and neuro-controller. The low-frequency oscillation is modeled by the neuro-identifier using the power flow dynamics, then a generalized backpropagation-through-time (GBTT) algorithm is developed to train the neuro-controller. The simulation results show that the neuro-PSS designed in this paper performs well with good damping in a wide operation range compared with the conventional PSS     

Design of optimum signals for the simultaneous estimation of timedelay and Doppler shift

The problem of joint estimation of time delay and Doppler shift is considered from the point of view of the Wigner distribution of the signal. A very efficient method of obtaining the optimum signal with minimum estimation error based on the convexity of the design region is developed. Practical applications, however, require the signal to satisfy other constraints which present complications in acquiring the optimum signal. A design approach based on the method of simulated annealing is suggested to solve for the optimum signal under constraints. The performance of the signals so obtained is evaluated and compared with that of signals obtained by synthesis     

On the behavior of microstructures with multiple length scales

The current study aims to provide fundamental insight into the behavior of microstructures containing grain sizes that span multiple length scales. A commercial 5083 Al alloy was selected as the material of interest to facilitate comparison with recently published data. The materials studied here were prepared via the thermal consolidation of powders that were cryomilled for different times (i.e., 0, 2, 4, and 8 hours). Following consolidation, the resultant microstructure was characterized by an equiaxed grain morphology with a size distribution centered around 200∼300 nm. Dispersed among the 200- to 300-nm grains were coarse-grained regions or ligaments with a grain size ranging from 600 nm to 2 μm. The occurrence of coarse-grained regions is rationalized on the basis of recrystallization or subgrain coarsening, whereas the occurrence of equiaxed fine regions is proposed to be a result of continuous grain growth. Two types of microstructures were selected for study, containing coarse-grained volumes of approximately 28 pct and 43 pct that corresponded to an ultimate tensile strength (UTS) of 566 MPa and 535 MPa, and a fracture strain of 3.2 pct and 3.5 pct, respectively. The observed ductility and the relevant toughening mechanisms were discussed in light of the presence of multiple length scales.     

Pattern Effect Removal Technique for Semiconductor-Optical-Amplifier-Based Wavelength Conversion

A technique to overcome pattern dependence in semiconductor-optical-amplifier-based wavelength converters is presented. The technique is based on a careful selection of red- and blue-shifted spectral components having complementary pattern effects in the output spectrum of a wavelength-converted signal. Significant signal quality improvements are reported at a bit rate of 40 Gb/s.     

大花水水电站首部枢纽布置设计

大花水水电站首部枢纽由碾压混凝土拦河大坝、泄洪建筑物和电站进水口组成。大坝采用河床拱坝 左岸重力坝的组合坝型,拱坝最大坝高134.50 m,重力坝最大坝高73 m。泄洪建筑物布置在拱坝坝身,为3个表孔 2个中孔的布置型形式。电站进水口布置于左岸重力坝坝身。首部枢纽布置紧凑,而且充分考虑了坝址区河谷狭窄、地形地貌及、存在的地质缺陷,以及泄洪流量大等工程特点。本文重点介绍首部枢纽的布置设计比选过程。     

大庆油田油气勘探“五五”工程的实践与效果

大庆油田公司确立的油气勘探“五五”工程的核心是立足油气勘探长远发展、统筹老区与新领域勘探,兼顾工程实施与地质研究、系统配套相关技术理论,内容是调整工程和投资结构、完善油气勘探地质理论、发展各项适用技术,目的是促进油气勘探寻求大发现、获得大突破。通过实施“五五”工程,勘探工作运行平稳,勘探成果殷实丰硕,勘探领域层次分明,对油气勘探工作的发展产生了巨大的推动力,确保了大庆探区油气勘探实施的效果。通过对油气勘探“五五”工程实践过程的深入剖析,认为在油气勘探中“思路决定出路、前置加载量是基础、新技术应用是关键”。     

Compact Dipole Antenna for Terrestrial Digital Multimedia Broadcasting Service

A compact dipole antenna for the terrestrial digital multimedia broadcasting (TDMB) application is presented. The length of the antenna is about 0.06λ at the TDMB resonance frequency of 190 MHz. Miniaturization of the antenna is achieved by using meander structures and lumped elements. The proposed antenna has two resonance frequencies and covers the TDMB band from 174 MHz to 216 MHz in Korea. The antenna has good impedance bandwidth and radiation characteristics for the TDMB. The experimental results of the designed dipole antenna are presented and analyzed.