地沟油对湘潭海泡石原矿粉体的表面改性

以地沟油为改性剂,利用催化剂作用,在常温水相条件下对湘潭海泡石原矿粉进行了表面非极性化改性,制备表面疏水的海泡石粉体.采用X射线粉末衍射(XRD)、扫描电镜(SEM)、傅里叶红外光谱(FTIR)、化学滴定及表面电位等测试技术对矿粉物相组成、微观形貌和表面性能进行表征,研究地沟油对海泡石的改性机理.     

Maternal Prenatal Inflammation Increases Brain Damage Susceptibility of Lipopolysaccharide in Adult Rat Offspring via COX-2/PGD-2/DPs Pathway Activation

A growing body of research suggests that inflammatory insult contributes to the etiology of central nervous system diseases, such as depression, Alzheimer’s disease, and so forth. However, the effect of prenatal systemic inflammation exposure on offspring brain development and cerebral susceptibility to inflammatory insult remains unknown. In this study, we utilized the prenatal inflammatory insult model in vivo and the neuronal damage model in vitro. The results obtained show that prenatal maternal inflammation exacerbates LPS-induced memory impairment, neuronal necrosis, brain inflammatory response, and significantly increases protein expressions of COX-2, DP2, APP, and Aβ, while obviously decreasing that of DP1 and the exploratory behaviors of offspring rats. Meloxicam significantly inhibited memory impairment, neuronal necrosis, oxidative stress, and inflammatory response, and down-regulated the expressions of APP, Aβ, COX-2, and DP2, whereas significantly increased exploring behaviors and the expression of DP1 in vivo. Collectively, these findings suggested that maternal inflammation could cause offspring suffering from inflammatory and behavioral disorders and increase the susceptibility of offspring to cerebral pathological factors, accompanied by COX-2/PGD-2/DPs pathway activation, which could be ameliorated significantly by COX-2 inhibitor meloxicam treatment.     

Nanoscale Calculation of Proton-Induced DNA Damage Using a Chromatin Geometry Model with Geant4-DNA

Monte Carlo simulations can quantify various types of DNA damage to evaluate the biological effects of ionizing radiation at the nanometer scale. This work presents a study simulating the DNA target response after proton irradiation. A chromatin fiber model and new physics constructors with the ELastic Scattering of Electrons and Positrons by neutral Atoms (ELSEPA) model were used to describe the DNA geometry and the physical stage of water radiolysis with the Geant4-DNA toolkit, respectively. Three key parameters (the energy threshold model for strand breaks, the physics model and the maximum distance to distinguish DSB clusters) of scoring DNA damage were studied to investigate the impact on the uncertainties of DNA damage. On the basis of comparison of our results with experimental data and published findings, we were able to accurately predict the yield of various types of DNA damage. Our results indicated that the difference in physics constructor can cause up to 56.4% in the DNA double-strand break (DSB) yields. The DSB yields were quite sensitive to the energy threshold for strand breaks (SB) and the maximum distance to classify the DSB clusters, which were even more than 100 times and four times than the default configurations, respectively.     

环保型水基切削清洗液的研制

通过正交实验开发了一种环保型水基切削清洗液,具有很好的贮存安定性、透明度、耐蚀性以及合适的pH值,并在磨削加工中表现出了良好的润滑、清洗和防锈效果。     

Possible Role of GnIH as a Novel Link between Hyperphagia-Induced Obesity-Related Metabolic Derangements and Hypogonadism in Male Mice

Gonadotropin-inhibitory hormone (GnIH) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis and reproduction. However, whether GnIH is a molecular signal link of metabolism and the reproductive system, and thus, regulates reproductive activity as a function of the energy state, is still unknown. In the present study, we investigated the involvement of GnIH in glycolipid metabolism and reproduction in vivo, and in the coupling between these two processes in the testis level. Our results showed that chronic intraperitoneal injection of GnIH into male mice not only increased food intake and altered meal microstructure but also significantly elevated body mass due to the increased mass of liver and epididymal white adipose tissue (eWAT), despite the loss of testicular weight. Furthermore, chronic intraperitoneal administration of GnIH to male mice resulted in obesity-related glycolipid metabolic derangements, showing hyperlipidemia, hyperglycemia, glucose intolerance, and insulin resistance through changes in the expression of glucose and lipid metabolism-related genes in the pancreas and eWAT, respectively. Interestingly, the expression of GnIH and GPR147 was markedly increased in the testis of mice under conditions of energy imbalance, such as fasting, acute hypoglycemia, and hyperglycemia. In addition, chronic GnIH injection markedly inhibited glucose and lipid metabolism of mice testis while significantly decreasing testosterone synthesis and sperm quality, inducing hypogonadism. These observations indicated that orexigenic GnIH triggers hyperphagia-induced obesity-related metabolic derangements and hypogonadism in male mice, suggesting that GnIH is an emerging candidate for coupling metabolism and fertility by involvement in obesity and metabolic disorder-induced reproductive dysfunction of the testes.     

基于离散滑模控制的新型Buck-Boost矩阵变换器

摘要对目前矩阵变换器存在电压传输比低的缺陷进行了研究,提出了一种新型的杯为buck-boost矩阵变换器（BBMC）的电路拓扑结构。介绍了该拓扑结构的基本构成及其工作原理,分析推导了其电压传输比与占空比之间函数关系的解析表达式,阐述了离散滑模控制策略的基本设计方法,最后通过仿真对其有效性和可行性进行了验证。结果表明：该新型拓扑结构能实现输出电压和频率的任意调节,其电压传输比既可大于1,也司小于l,且直接输出高品质的正弦波而无需滤波环节,谐波含量小,从而有效解决了传统矩阵变换器申,压传输比低的难题,具有较好的应用价值。     

基于时空滤波的无线传感器网络抗差节点定位算法

针对无线传感器网络的最小二乘定位算法抗差性的不足,提出了一种基于时空滤波(STF)的抗差性加权最小二乘(WLS)节点定位算法--STLS.该算法基于空间域滤波的数据一致性检测算法利用相邻节点间必须满足的几何约束关系,采用优化矩阵操作,剔除粗差邻居节点,其计算复杂度为多项式的平方.通过使用具有2步收敛特性的DFP算法,最小化目标代价函数,实现节点的快速定位.实验结果表明,在均匀网格拓扑或各向异性C型网格拓扑下,该算法均可有效识别和剔除测距低估粗差点,其定位精度明显优于未进行空间一致性检测的加权最小二乘定位算法,当网络平均连通度较低时,该优势表现得尤为明显.     

DG1025/18.2-II4型锅炉风粉混合器改造探讨

针对四川巴蜀江油燃煤发电有限公司2×300 MW机组在投运初期锅炉给粉均匀性差的问题,找出了风粉混合器结构不合理是导致给粉均匀性差的原因.经分析研究利用引流原理对原来安装的风粉混合器进行改进,消除托粉现象,提高进入炉膛给粉均匀性,经过改进后的风粉混合器已使用半年多,应用结果表明其特性良好,提高了锅炉燃烧的稳定性和经济性.     

移动荷载下复合路面的数值分析

应用有限元数值计算方法,分析了复合路面在移动荷载下的动力响应问题.针对多层结构体系,建立了相应的有限元实体模型,并进行了动力响应分析.分别讨论了复合路面在不同车速的作用下的位移和应力变化.计算结果表明,车辆速度对路面的结构力学响应有较大影响,在路面设计和疲劳寿命设计中需要充分考虑振动和冲击载荷的影响. 更多还原     

不同电导率的PEDOT对聚合物光电池性能的影响

采用几种具有不同电导率的PEDOT(poly(3,4-ethylene dioxythiophene)),研究其对器件性能的影响,结果表明高电导率的PEDOT与ITO(Indium tin oxide)一起作为光电池的阳极,有利于光电池能量转换效率的提高.探讨了高电导率PEDOT的厚度与器件性能之间的相关性,表明在保证器件不漏电的前提下PEDOT的厚度越薄越好.