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31.
Provides an overview of the 1995 Consumer Reports survey of the effectiveness of psychotherapy. Specific issues addressed include the study's goals; the findings for mental health professionals, family doctors, and self-help groups; and methodological strengths and weaknesses related to external validity, sampling, controls, self-reports, and time frame. The data show that, free of the artificial constraints of controlled studies in the real world, a population of consumers can often benefit from psychological intervention services. Real relief can be found at the hands of professional mental health providers. M. Kotkin et al reaffirm their independence from M. E. P. Seligman (see record 1996-13324-001) regarding the interpretation of the data. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
32.
由于Joel Spolsky的双重身份(昔日耶鲁大学计算机系学长,今日Fog Creek软件公司的OEO),所以听听他的建议,对于当今无数困扰于就业压力的中国高校计算机专业学子来说,是大有裨益的。你们会发现,大多数建议,都在强调“软实力”的价值。本文转载自《软件随想录》(作者:Joel Spolsky,译者:阮一峰,2009年12月出版),感谢北京图灵文化发展有限公司的支持。 相似文献
33.
Naga Vydyanathan Umit Catalyurek Tahsin Kurc Ponnuswamy Sadayappan Joel Saltz 《Parallel Computing》2011,37(10-11):694-712
Scheduling, in many application domains, involves optimization of multiple performance metrics. For example, application workflows with real-time constraints have strict throughput requirements and also desire a low latency or response time. In this paper, we present a novel algorithm for the scheduling of workflows that act on a stream of input data. Our algorithm focuses on the two performance metrics, latency and throughput, and minimizes the latency of workflows while satisfying strict throughput requirements. We also describe steps to use the above approach to solve the problem of meeting latency requirements while maximizing throughput. We leverage pipelined, task and data parallelism in a coordinated manner to meet these objectives and investigate the benefit of task duplication in alleviating communication overheads in the pipelined schedule for different workflow characteristics. The proposed algorithm is designed for a realistic bounded multi-port communication model, where each processor can simultaneously communicate with at most k distinct processors. Experimental evaluation using synthetic benchmarks as well as those derived from real applications shows that our algorithm consistently produces lower latency schedules that meet throughput requirements, even when previously proposed schemes fail. 相似文献
34.
Mario A. S. Lizi��r Marcelo F. Siqueira Joel Daniels II Claudio T. Silva L. Gustavo Nonato 《The Visual computer》2011,27(10):887-903
This paper describes a novel template-based meshing approach for generating good quality quadrilateral meshes from 2D digital
images. This approach builds upon an existing image-based mesh generation technique called Imeshp, which enables us to create a segmented triangle mesh from an image without the need for an image segmentation step. Our
approach generates a quadrilateral mesh using an indirect scheme, which converts the segmented triangle mesh created by the
initial steps of the Imesh technique into a quadrilateral one. The triangle-to-quadrilateral conversion makes use of template meshes of triangles. To
ensure good element quality, the conversion step is followed by a smoothing step, which is based on a new optimization-based
procedure. We show several examples of meshes generated by our approach, and present a thorough experimental evaluation of
the quality of the meshes given as examples. 相似文献
35.
Joel Ratsaby 《Annals of Mathematics and Artificial Intelligence》2008,52(1):55-65
Consider a class of binary functions h: X→{ − 1, + 1} on an interval . Define the sample width of h on a finite subset (a sample) S ⊂ X as ω
S
(h) = min
x ∈ S
|ω
h
(x)| where ω
h
(x) = h(x) max {a ≥ 0: h(z) = h(x), x − a ≤ z ≤ x + a}. Let be the space of all samples in X of cardinality ℓ and consider sets of wide samples, i.e., hypersets which are defined as Through an application of the Sauer-Shelah result on the density of sets an upper estimate is obtained on the growth function
(or trace) of the class , β > 0, i.e., on the number of possible dichotomies obtained by intersecting all hypersets with a fixed collection of samples
of cardinality m. The estimate is .
相似文献
36.
Mosaliganti K Cooper L Sharp R Machiraju R Leone G Huang K Saltz J 《IEEE transactions on visualization and computer graphics》2008,14(4):863-876
Developments in optical microscopy imaging have generated large high-resolution data sets that have spurred medical researchers to conduct investigations into mechanisms of disease, including cancer at cellular and subcellular levels. The work reported here demonstrates that a suitable methodology can be conceived that isolates modality-dependent effects from the larger segmentation task and that 3D reconstructions can be cognizant of shapes as evident in the available 2D planar images. In the current realization, a method based on active geodesic contours is first deployed to counter the ambiguity that exists in separating overlapping cells on the image plane. Later, another segmentation effort based on a variant of Voronoi tessellations improves the delineation of the cell boundaries using a Bayesian formulation. In the next stage, the cells are interpolated across the third dimension thereby mitigating the poor structural correlation that exists in that dimension. We deploy our methods on three separate data sets obtained from light, confocal, and phase-contrast microscopy and validate the results appropriately. 相似文献
37.
Saastamoinen A Huupponen E Värri A Hasan J Himanen SL 《Computer methods and programs in biomedicine》2006,82(1):58-66
In this article, we present a new implementation of an amplitude-independent method for continuous-scale sleep depth estimation. Having been implemented as an add-on analysis module under commercially available biosignal recording and analysis software, it can be easily applied in clinical routine. The software gives the user full freedom to change all the analysis parameters inside theoretical limits. Computational sleep depth profiles produced by the presented software compare favourably with visual classifications. Future work will concentrate on systematic optimization of analysis parameters, further evaluation of the method with disturbed sleep and application of the method for automated adaptive sleep analysis. 相似文献
38.
Sobhani AM Amini SR Tyndall JD Azizi E Daneshtalab M Khalaj A 《Journal of molecular graphics & modelling》2006,25(4):459-469
Azolylalkylquinolines (AAQs) are a family of quinolines with varying degrees of cytotoxic activity (comparable or moderately superior to adriamycin in some cases) developed in the past decade in our group where their exact mode of action is still unclear. In this study the most probable DNA binding mode of AAQs was investigated employing a novel flexible ligand docking approach by using AutoDock 3.0. Forty-nine AAQs with known experimental inhibitory activity were docked onto d(CGCAAATTTGCG)(2), d(CGATCG)(2) and d(CGCG)(2) oligonucleotides retrieved from the Protein Data Bank (PDB IDs: 102D, 1D12 and 1D32, respectively) as the representatives of the three plausible models of interactions between chemotherapeutic agents and DNA (groove binding, groove binding plus intercalation and bisintercalation, respectively). Good correlation (r(2)=0.64) between calculated binding energies and experimental inhibitory activities was obtained using groove binding plus intercalation model for phenyl-azolylalkylquinoline (PAAQ) series. Our findings show that the most probable mode of action of PAAQs as DNA binding agents is via intercalation of quinolinic moiety between CG base pairs with linker chain and azole moiety binding to the minor groove. 相似文献
39.
40.
Using fluorescence in situ hybridization technique, expression of three oncogenes, C-myc, RARa, and cyclin-D was tested on a uterine leiomyoma. C-myc and RARa were amplified in approximately 30% and 90% of the cells, respectively. Numerous small signals of C-myc were indicative of the presence of double minutes. Amplification of RARa is being reported for the first time in a leiomyoma. Cyclin-D was normal in diploid cells while it was highly amplified in polyploid cells. Low levels of amplified C-myc and cyclin-D cells seem to be the reason for this tumor to be benign, while RARa could not be effective without the association of some other gene such as PML. Information presented here are significant toward developing new curative strategies such as gene-specific drugs and molecular manipulation to stop the activity of cancer gene. Further study may elucidate that how fibroids grow and maintain their rare benign nature. 相似文献