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61.
62.
A two-layer architecture for dynamic real-time optimization (or nonlinear modelpredictive control (NMPC) with an economic objective) is presented, where the solution of the dynamic optimization problem is computed on two time-scales. On the upper layer, a rigorous optimization problem is solved with an economic objective function at a slow time-scale, which captures slow trends in process uncertainties. On the lower layer, a fast neighboring-extremal controller is tracking the trajectory in order to deal with fast disturbances acting on the process. Compared to a single-layer architecture, the two-layer architecture is able to address control systems with complex models leading to high computational load, since the rigorous optimization problem can be solved at a slower rate than the process sampling time. Furthermore, solving a new rigorous optimization problem is not necessary at each sampling time if the process has rather slow dynamics compared to the disturbance dynamics. The two-layer control strategy is illustrated with a simulated case study of an industrial polymerization process.  相似文献   
63.
Aspect-oriented programming (AOP) seeks to improve software modularity via the separation of cross-cutting concerns. AOP proponents often advocate a development strategy where programmers write the main application (base code), ignoring cross-cutting concerns, and then aspect programmers, domain experts in their specific concerns, weave in the logic for these more specialized cross-cutting concerns. This purely oblivious strategy, however, has empirically been shown to tightly couple aspects to base code in many cases, hindering aspect modularity and reuse. In essence, the more intricate the weaving between the cross-cutting concern and the base code (lexically and/or semantically), the harder it becomes to: (a) robustly specify how to weave the aspects in at the required points, (b) capture interactions between aspects and base code, and (c) preserve the correct weaving as the base code evolves.We propose an alternate methodology, termed cooperative aspect-oriented programming (Co-AOP), where complete lexical separation of concerns is not taken as an absolute requirement. Instead, cross-cutting concerns are explicitly modeled as abstract interfaces through explicit join points (EJPs). Programmers specify where these interfaces interact with base code either through explicit lexical references or via traditional oblivious aspects. This explicit awareness allows base code and aspects to cooperate in ways that were previously not possible: arbitrary blocks of code can be advised, advice can be explicitly parameterized, base code can guide aspects in where to apply advice, and aspects can statically enforce new constraints upon the base code that they advise. These new techniques allow aspect modularity and program safety to increase, and bring us towards a cooperative AOP paradigm.We illustrate our methodology via an example on transactions, and also give an initial evaluation of cooperative AOP through an empirical study on program extensibility comparing both the traditional and cooperative AOP methodologies. Initial results show that cooperative AOP techniques result in code that is less complex with lower overall coupling, facilitating extensibility.  相似文献   
64.
65.
The purpose of this research is to identify the potential information components of an online, real-time trust label, which is proposed as a communication mechanism to encourage trust in cloud service providers and cloud computing products. An online Delphi process was used with 28 cloud computing experts (including vendors, software providers, and legal and business representatives). The proposed label contains 81 information components, covering the cloud service provider (e.g. physical location, legal jurisdiction), the cloud service itself (e.g. data location, security, backup, certification), and a historical service-level summary (e.g. uptime data, support response times). The potential benefits of such a label to encourage trustworthiness perceptions and trust behaviors in the cloud computing environment are explored. Limitations of the study are highlighted, and further research studies are suggested to test the concept of the label and to refine the components of the label itself.  相似文献   
66.

Background

Premature infants represent a significant proportion of the neonatal intensive care population. Blood glucose homeostasis in this group is often disturbed by immaturity of endogenous regulatory systems and the stress of their condition. Hypo- and hyperglycemia are frequently reported in very low birth weight infants, and more mature infants often experience low levels of glycemia. A model capturing the unique fundamental dynamics of the neonatal glucose regulatory system could be used to develop better blood glucose control methods.

Methods

A metabolic system model is adapted from adult critical care to the unique physiological case of the neonate. Integral-based fitting methods were used to identify time-varying insulin sensitivity and non-insulin mediated glucose uptake profiles. The clinically important predictive ability of the model was assessed by assuming insulin sensitivity was constant over prediction intervals of 1, 2 and 4 h forward and comparing model-simulated versus actual clinical glucose values for all recorded interventions. The clinical data included 1091 glucose measurements over 3567 total patient hours, along with all associated insulin and nutritional infusion data, for N = 25 total cases. Ethics approval was obtained from the Upper South A Regional Ethics Committee for this study.

Results

The identified model had a median absolute percentage error of 2.4% [IQR: 0.9-4.8%] between model-fitted and clinical glucose values. Median absolute prediction errors at 1-, 2- and 4-h intervals were 5.2% [IQR: 2.5-10.3%], 9.4% [IQR: 4.5-18.4%] and 13.6% [IQR: 6.3-27.6%] respectively.

Conclusions

The model accurately captures and predicts the fundamental dynamic behaviors of the neonatal metabolism well enough for effective clinical decision support in glycemic control. The adaptation from adult to a neonatal case is based on the data from the literature. Low prediction errors and very low fitting errors indicate that the fundamental dynamics of glucose metabolism in both premature neonates and critical care adults can be described by similar mathematical models.  相似文献   
67.
A feature relies on three dimensions (space, theme, and time) for its representation. Even though spatiotemporal models have been proposed, they have principally focused on the spatial changes of a feature. In this paper, a feature-based temporal model is proposed to represent the changes of both space and theme independently. The proposed model modifies the ISO’s temporal schema and adds new explicit temporal relationship structure that stores temporal topological relationship with the ISO’s temporal primitives of a feature in order to keep track feature history. The explicit temporal relationship can enhance query performance on feature history by removing topological comparison during query process. Further, a prototype system has been developed to test a proposed feature-based temporal model by querying land parcel history in Athens, Georgia. The result of temporal query on individual feature history shows the efficiency of the explicit temporal relationship structure.
E. Lynn UseryEmail:
  相似文献   
68.
Despite their decade of deployment, educational digital libraries have not achieved sustained use in elementary and secondary schools in the United States. Barriers to accessing the Internet and computers have been widely targeted by myriad initiatives, but efforts aimed at bridging this first-level “digital divide” have not led to increased use of the Internet and digital library resources in U.S. classrooms. In fact, such programs have revealed additional divides that affect educators’ use. This paper examines the additional digital divide levels and proposes a new framework for understanding technology innovation in schools that can improve development and outreach approaches by digital library developers.  相似文献   
69.
From Dec 23, 1978, through Jan 31, 1979, an outbreak of five laboratory-confirmed cases and four clinical cases of measles occurred in a Vietnamese refugee population living in a single housing complex in Albuquerque, NM. The index cases were in two refugee siblings in whom measles was incubating on arrival in the United States. Despite spread through three subsequent generations of disease transmission within the Vietnamese population, there was no additional spread into the general Albuquerque population. Responsible factors included the age distribution of susceptible persons, the social isolation of the refugee population, and the physical structure of the housing complex. There is a need to identify the problem of imported measles in "ethnic islands" in need of vaccination.  相似文献   
70.
In this paper, a particular class of nano-diamond films deposited by energetic species is described. Deposition is carried out using the direct-current glow-discharge (DC GD) deposition technique from a methane/hydrogen mixture. In this method, film growth occurs from energetic species being accelerated and incorporated into the film surface. The growth of the nano-diamond film occurs on top of a preferentially oriented graphitic precursor with its basal planes perpendicular to the substrate surface. The nano-diamond films consist of an agglomerate of diamond particles with particle sizes in the 3-5 nm range with amorphous grain boundaries. The hydrogen concentration in the graphitic precursor is only a few percent; however, it increases to ∼15-20 at.% in the nano-diamond film.From a microscopic perspective nano-diamond film and growth from energetic species is explained as a sub-surface process in terms of a four-step cyclic process. The DC GD-deposited nano-diamond films were comprehensively explored by a number of complementary techniques. The hydrogen content and its role in nano-diamond film formation were assessed. The experimental methods used in our studies comprise near-edge X-ray adsorption fine structure (NEXAFS) to prove the short-range coordination of the carbon films and indirectly their phase composition. The surface and grain boundary phase composition were investigated by a combination of electron energy loss spectroscopy (EELS) measured as a function of incident electron energy and hydrogen etching experiments. By transmission electron microscopy (TEM), the micro-structural evolution and their visualization were achieved. The density evolution of the films was determined by X-ray reflectivity (XRR). The hydrogen content and its distribution in the films were studied by secondary ion microscopy spectroscopy (SIMS) and elastic recoil detection (ERD). The hydrogen bonding was investigated by high-resolution electron energy loss spectroscopy (HREELS).Most likely, hydrogen is bonded within the amorphous grain boundaries and saturates the nano-diamond particles. The surface of the films is amorphous in nature.  相似文献   
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