Preparation of Poly(D,L-Lactide/Glycolide) Nanoparticles of Controlled Particle Size Distribution: Application of Experimental Designs

This study investigates the use of the solvent evaporation method for preparing acid and glycolic acid-based copolymer nanoparticles. Initially, appropriate technological and formulation factors for elaboration of polymeric particles were selected by screening. Most favourable results were obtained using polyvinyl alcohol as a dispersing agent and a high pressure homogenizer to reduce the droplet size of the emulsion initially formed. On the basis of the conclusion thus drawn, a composite rotational experimental design was employed to evaluate the joint influence of three formulation variables (phase volume ratio of the emulsion formed, polymer concentration and homogenization pressure) on the micromeritic properties of the suspension finally obtained (mean particle size, coefficient of variation and polydispersity of the particle size distribution). Analysis of variance corresponding to the experimental design, showed a significant influence of the volume phase ratio and the polymer concentration on the mean particle size and the coefficient of variation, whereas the polydispersity is also affected by the homogenization pressure. Considering this information, a 3² experimental factorial design was then selected to investigate the possible interaction between the phase volume ratio and the concentration of polyvinyl alcohol in the aqueous phase. Analysis of variance and subsequent sequencial regression analysis evidenced last hypothesis providing the way to determine the experimental conditions required to achieve a specific particle size distribution.     

A mathematical model for the prediction of temperature in a dry snow layer

A mathematical model for predicting the temperature in a homogeneous layer of dry snow is presented. The model, which is physically based, is capable of predicting diurnal temperature behaviour at the snow surface and at any depth within a snow layer given the variation in a limited set of meteorological parameters over that period. A sensitivity analysis is performed to determine the important parameters in the prediction of snow surface temperatures. These are found to be consistent with simple physical reasoning.     

Evolution of BET internal surface area in glassy carbon powder during thermal oxidation

It is demonstrated that glassy carbon powder can be thermochemically activated. During activation, a film with open pores is created on the glassy carbon particles. This film has a large internal surface area, which is accessible to liquids and gases. A simple model for the evolution of the internal surface area in glassy carbon powder during thermochemical gas-phase oxidation is also presented and compared with experimental data. Experimental results are in qualitative agreement with the model. We found that a sharp particle size distribution is desirable with regard to potential technical applications.     

A problem of pursuit and evasion

A trajectory problem of pursuit and evasion on a plane is considered for the case of equal absolute velocities of the players. Exact solutions are obtained for fixed initial conditions.Translated from Kibernetika i Sistemnyi Analiz, No. 3, pp. 138–143, May–June, 1992.     

The Principles of Calculus of Behavior Scenarios of Complex Systems in the ECS

Theoretical results of the development of the principles of scenario calculus are presented, which are obtained in the framework of the design of an emergency control system (ECS). Relying on the suggested system concept of the formation of a scenario system, consideration is given to the principles of the construction of operations in scenario spaces, which account for specific features of the scenario analysis and the process of the decision-making in the ECS. Principal problems of the development of scenario calculus on the basis of a system approach are treated, the classification of operations on scenarios is given, and a number of operations on elements of the basic metacollection are formalized.     

A family of converters for UPS production burn-in energy recovery

This paper introduces a family of power converters for power recycling during the burn-in test of synchronized uninterruptible power supplies (UPSs) with sinusoidal output voltage. The use of the power recycler to replace the resistor load bank in the UPSs burn-in test causes great energy savings, and the optimized use of electrical energy contributes in reducing the final cost of the product. The main feature of the new circuits is their ability to draw from the UPS and to inject into the utility-grid currents with low total harmonic distortion (THD) and high power factor (PF). The new circuits operate at constant frequency and are regulated by conventional pulse width modulation (PWM) using dedicated PWM and PF controller integrated circuits developed for power supplies. Circuit operation, mathematical analysis, design example, and experimental results for discontinuous current mode (DCM) and continuous current mode (CCM) operation are provided in this paper