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31.
Nelson Linda D.; Mitrushina Maura; Satz Paul; Sowa Marian; Cohen Stanley 《Canadian Metallurgical Quarterly》1993,5(3):374
Internal stability and discriminant validity of the Neuropsychology Behavior and Affect Profile (L. Nelson et al, 1989) were examined in samples of 70 stroke patients and 88 elderly controls. The test is designed to yield indices of premorbid (before-item subset) and present (now-item subset) levels of emotional functioning in each of 5 scales. With coefficient alphas ranging from .76 to .87, results indicated moderate to high internal stability. The test was also able to reliably distinguish between the criterion stroke sample (n?=?42) and a matched group of elderly controls in terms of present levels of emotional functioning (2 wks poststroke). When discriminant validity was examined in terms of premorbid emotional status (before-item subset), group differences were unexpectedly obtained. Clinical and research implications of these results are discussed, noting the possibility of early, noncognitive correlates preceding stroke. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
32.
Neuronal activation was examined by fos immunohistochemistry in ring doves (Streptopelia risoria) reunited with their young after overnight separation. In an initial study, squab-exposed parents showed more fos immunoreactivity (ir) in the preoptic area (POA) and lateral hypothalamus (LH) than squab-deprived parents. In a 2nd study, parents allowed free access to young and those separated from young by a wire mesh partition showed more fos-ir in the POA, LH, and lateral septum than box-exposed controls. Contact with young also increased fos-ir in the medial preoptic nucleus and bed nucleus of the stria terminalis, but noncontact exposure did not. Conversely, nontactile squab exposure stimulated more fos-ir in the POA than did free access to young, which suggests POA involvement in appetitive aspects of parenting. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
33.
Linda Kwai-Lin Lau Rajeev Jain Henry Samueli Henry T. Nicholas III Etan G. Cohen 《The Journal of VLSI Signal Processing》1992,4(2-3):213-226
This paper presents a functional compiler for the automatic design of Direct Digital Frequency Synthesizer (DDFS) integrated circuits (ICs) using a ROM based table look-up architecture. The compiler allows the user to specify high-level specifications such as the acceptable spurious response and it generates the IC architecture, floorplan, and layout. To construct the layout for different specifications, a library of parameterized macrocells has been developed in 1.2 m CMOS technology.A test chip with a quadrature DDFS module has been generated, using the compiler, and fabricated. The chip has two input signals: one is for frequency control while the other is for phase initialization. Input and output word lengths are 16 bits and 6 bits respectively. The chip complexity is approximately 12,000 transistors (DDFS core) and the die size is 4.8×2.9mm
2. A maximum sample rate of 80 MHz has been attained implying a maximum sine (cosine) output frequency of 40 MHz and a frequency resolution of 1.22 kHz. The maximum spurious level measured is –46 dB. 相似文献
34.
Linda L. Clements 《Journal of Materials Science》1986,21(6):1853-1862
The tensile failure surfaces of (0°)8 T300/5208 graphite-epoxy specimens were examined using both optical and scanning electron microscopy. Fractography was used to determine how moisture content and temperature as well as specimen preparation technique, prepreg batch and cure condition affected the failure mode. A distinctive low-energy failure morphology was found in defective specimens and also in those whose edges were poorly prepared. This morphology was predominant in failures at elevated temperature or moisture content for specimens which had been made from one suspect batch of prepreg. This finding combined with unusual end-tab failures from such specimens indicated that this batch was indeed defective, but that such defective batches could in the future be identified by tests under hot, wet conditions. For specimens made from good prepreg, temperature or moisture appeared to decrease flaw sensitivity and thus increase strength, even though moisture also seemed to increase interfacial debonding between filament and matrix. When combined, moisture and temperature appeared to degrade performance by increasing interfacial debonding and making the epoxy matrix more prone to fracture. 相似文献
35.
Conventional access methods cannot be effectively used in large Scientific/Statistical Database (SSDB) applications. A file structure (called bit transposed file (BTF)) is proposed which offers several attractive features that are better suited for the special characteristics that SSDBs exhibit. This file structure is an extreme version of the (attribute) transposed file. The data are stored by vertical bit partitions. The bit patterns of attributes are assigned using one of several data encoding methods. Each of these encoding methods is appropriate for different query types. The bit partitions can also be compressed using a version of the run length encoding scheme. Efficient operators on compressed bit vectors have been developed and form the basis of a query language. Because of the simplicity of the file structure and query language, optimization problems for database design, query evaluation, and common subexpression removal can be formalized and efficient exact solution or near optimal solution can be achieved. In addition to selective power with low overheads for SSDBs, the BTF is also amenable to special parallel hardware. Results from experiments with the file structure suggest that this approach may be a reasonable alternative file structure for large SSDBs. 相似文献
36.
37.
Neuroprotective Effects of Testosterone in the Hypothalamus of an Animal Model of Metabolic Syndrome
Erica Sarchielli Paolo Comeglio Sandra Filippi Ilaria Cellai Giulia Guarnieri Alessandra Marzoppi Sarah Cipriani Linda Vignozzi Annamaria Morelli Mario Maggi 《International journal of molecular sciences》2021,22(4)
Metabolic syndrome (MetS) is known to be associated to inflammation and alteration in the hypothalamus, a brain region implicated in the control of several physiological functions, including energy homeostasis and reproduction. Previous studies demonstrated the beneficial effects of testosterone treatment (TTh) in counteracting some MetS symptoms in both animal models and clinical studies. This study investigated the effect of TTh (30 mg/kg/week for 12 weeks) on the hypothalamus in a high-fat diet (HFD)-induced animal model of MetS, utilizing quantitative RT-PCR and immunohistochemical analyses. The animal model recapitulates the human MetS features, including low testosterone/gonadotropin plasma levels. TTh significantly improved MetS-induced hypertension, visceral adipose tissue accumulation, and glucose homeostasis derangements. Within hypothalamus, TTh significantly counteracted HFD-induced inflammation, as detected in terms of expression of inflammatory markers and microglial activation. Moreover, TTh remarkably reverted the HFD-associated alterations in the expression of important regulators of energy status and reproduction, such as the melanocortin and the GnRH-controlling network. Our results suggest that TTh may exert neuroprotective effects on the HFD-related hypothalamic alterations, with positive outcomes on the circuits implicated in the control of energy metabolism and reproductive tasks, thus supporting a possible role of TTh in the clinical management of MetS. 相似文献
38.
Luis O. Soto-Rojas Mar Pacheco-Herrero Paola A. Martínez-Gmez B. Berenice Campa-Crdoba Ricardo Aptiga-Prez Marcos M. Villegas-Rojas Charles R. Harrington Fidel de la Cruz Linda Garcs-Ramírez Jos Luna-Muoz 《International journal of molecular sciences》2021,22(4)
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic plaques, and around blood vessels as cerebral amyloid angiopathy (CAA). According to the vascular hypothesis of AD, vascular risk factors can result in dysregulation of the neurovascular unit (NVU) and hypoxia. Hypoxia may reduce Aβ clearance from the brain and increase its production, leading to both parenchymal and vascular accumulation of Aβ. An increase in Aβ amplifies neuronal dysfunction, NFT formation, and accelerates neurodegeneration, resulting in dementia. In recent decades, therapeutic approaches have attempted to decrease the levels of abnormal Aβ or tau levels in the AD brain. However, several of these approaches have either been associated with an inappropriate immune response triggering inflammation, or have failed to improve cognition. Here, we review the pathogenesis and potential therapeutic targets associated with dysfunction of the NVU in AD. 相似文献
39.
Luis O. Soto-Rojas B. Berenice Campa-Crdoba Charles R. Harrington Andrs Salas-Casas Mario Hernandes-Alejandro Ignacio Villanueva-Fierro Marely Bravo-Muoz Linda Garcs-Ramírez Fidel De La Cruz-Lpez Miguel ngel Ontiveros-Torres Goar Gevorkian Mar Pacheco-Herrero Jos Luna-Muoz 《International journal of molecular sciences》2021,22(7)
Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in the brain parenchyma and around cerebral blood vessels. According to the vascular hypothesis of AD, an alteration in the neurovascular unit (NVU) could lead to Aβ vascular accumulation and promote neuronal dysfunction, accelerating neurodegeneration and dementia. To date, the effects of insoluble vascular Aβ deposits on the NVU and the blood–brain barrier (BBB) are unknown. In this study, we analyze different Aβ species and their association with the cells that make up the NVU. We evaluated post-mortem AD brain tissue. Multiple immunofluorescence assays were performed against different species of Aβ and the main elements that constitute the NVU. Our results showed that there are insoluble vascular deposits of both full-length and truncated Aβ species. Besides, insoluble aggregates are associated with a decrease in the phenotype of the cellular components that constitute the NVU and with BBB disruption. This approach could help identify new therapeutic targets against key molecules and receptors in the NVU that can prevent the accumulation of vascular fibrillar Aβ in AD. 相似文献
40.
Tjokorde W. Samadhi Linda E. Jones Alexis G. Clare 《Journal of the American Ceramic Society》2003,86(12):2044-2049
Carbon reacts with Na2 SO4 in glass batches, influencing SO x emissions. To study the role of carbon active surface area (ASA) in the decomposition phenomena, Na2 SO4 is reacted with three carbons with a wide ASA range. The decomposition behavior was evaluated by thermogravimetric analysis (TGA) and evolved gas analysis via mass spectrometry and Fourier transform infrared spectrometry. Higher carbon ASA yields lower decomposition temperatures. SO x emissions are realized at temperatures as low as 773 K. Isothermal Na2 SO4 –C decomposition initiates via the nucleation of Na2 S. The rate constants for the nucleation regime are normalized against ASA, yielding an activation energy of 275 kJ/mol for nucleation. 相似文献