Stability, in-Vitro and in-Vivo Release Studies from Metronidazole Ointments

The influence of ointment formulation on the stability, the in-vitro release and the in-vivo absorption through the skin of rabbits was investigated. The choice of the selected ointments has no influence on the drug stability with the exception of an acidified emulsion base. A good correlation between in-vitro release and in-vivo absorption was found revealing that metronidazole was quickly released and effectively absorbed from a polyethylene glycol base.     

Preparation of V/ZrO2 catalysts by the sol-gel method: Physical and structural characterization

Some zirconia-supported vanadium oxides have been prepared by sol-gel method and characterized by different techniques. The vanadium content exerts an effect on the area and pore-size of precursors and samples calcined. The presence of vanadium also affects the decomposition of precursors into ZrO₂ and to its phase transformation, as well as the formation of fibres, as shown by SEM-EDX. XPS analyses show the presence of two species of vanadium at the surface, V^5– and V⁴⁺, the percentage of each one depending on the load of vanadium in the catalyst.     

Study on phase behavior–impact strength relationship of unsaturated polyester/polyurethane hybrid polymer network

The phase behavior of a hybrid polymer network (HPN) composed of poly[(propylene glycol maleate)-co-(propylene glycol phthalate)] crosslinked with styrene and polyester–urethane crosslinked with methylene-bis-ortho-chloroaniline was examined. The correlation between phase separation and impact strength of the HPNs is discussed. The composition of HPNs has an effect on their properties.     

A D&T roundtable: challenges for low-power and high-performancechips

Microprocessor and other lC performance continues to improve at historic rates, with no visible end in sight for the next 10 years. However, we are starting to encounter a power wall. This is true for high-performance components as well as for low-power chips with a very limited energy budget offered by batteries. We need to find ways to manage power and energy consumption on all fronts-technology, design, and architecture-without compromising performance. Otherwise, we may face discontinuation of Moore's law for the semiconductor industry in the near future. This would be triggered not by any difficulty in the scaling of process technology but by formidable barriers posed by packaging and cooling, inefficacy of power delivery, and energy constraints dictated by battery technology, which is advancing at a very lukewarm pace     

Human catalase is imported and assembled in peroxisomes of Saccharomyces cerevisiae

To study the conservation of peroxisomal targeting signals, we have determined the intracellular localization of human peroxisomal catalase when expressed in yeast. Using immunofluorescence, differential centrifugation and immunoelectron microscopy, we show that the protein is targeted to the peroxisomes of the heterologous cell and assembled in its active tetrameric form. These data show the conservation of the catalase targeting signal and import specificity between human and yeast peroxisomes.     

The relationship of individual and family factors to the psychological well-being of junior high school students living in urban poverty

This study examined the contribution of individual and family factors to psychological adjustment in a sample of junior high school students living in urban poverty. Identity development and perceived parental treatment were hypothesized to serve as mediating, or protective, factors between economic hardship and levels of self-esteem, depression, and loneliness. Consistent with the hypotheses, identity development did serve as a mediator between poverty and psychological adjustment. While perceived parental treatment was not related to economic hardship, it was clearly associated with well-being in this sample. Findings are discussed in terms of the differing contributions of family and individual development, as well as the importance of mediators in assessing the effects of poverty on young adolescents.     

A note on closed-loop balanced truncation

Closed-loop balanced truncation is a model reduction method that aims at preserving the closed-loop properties of the original controller. We show that this method is equivalent to frequency-weighted balanced truncation with certain weighting and that for observer-based controllers, a significant amount of computation can be saved because of the observer-state feedback structure of the controller