Inhaled nitric oxide is not a myocardial depressant in a porcine model of heart failure

BACKGROUND: Inhaled nitric oxide has been shown to be a potent and selective pulmonary vasodilator. Reports of increases in left ventricular end-diastolic pressure and episodes of pulmonary edema during the clinical use of inhaled nitric oxide in patients with preexisting left ventricular dysfunction have raised concerns that this agent may have myocardial depressant effects. We therefore undertook a study of the effects of inhaled nitric oxide on myocardial contractility in a porcine model of ventricular failure and pulmonary hypertension. METHODS: After inducing heart failure in 10 pigs by rapid ventricular pacing, hemodynamic measurements and pressure-volume diagrams (by the conductance method) were obtained in six animals at baseline and during administration of inhaled nitric oxide at concentrations of 20 and 40 ppm. Myocardial contractile state was assessed by the end-systolic pressure-volume relationship and preload-recruitable stroke work, whereas diastolic function was measured in terms of the end-diastolic pressure-volume relationship and the pressure decay time constant T. RESULTS: Baseline hemodynamics reflected heart failure and pulmonary hypertension, and inhaled nitric oxide induced significant reductions in mean pulmonary artery pressure and pulmonary vascular resistance. Although left ventricular end-diastolic pressure increased during administration of inhaled nitric oxide, no changes were observed in measures of systolic or diastolic function. CONCLUSIONS: Inhaled nitric oxide reduced pulmonary vascular resistance but did not alter myocardial contractility or diastolic function. Increases in left ventricular end-diastolic pressure during inhaled nitric oxide therapy are therefore not due to myocardial depression and may be related to increases in volume delivery to the left side of the heart resulting from reduced pulmonary vascular resistance.     

钇、钪分离工艺的新进展

本文简要介绍中国科学院长春应用化学研究所近年来在钇、钪分离工艺研究方面的新进展。     

EC与~（99m）Tc－GH之间的配体交换反应动力学研究

实验表明，ＥＣ浓度与配体交换反应速度常数无关，体系的ｐＨ值对速度常数和９９ｍＴｃ－ＥＣ的标记率影响较大。测定并计算了不同ｐＨ值的交换反应速度常数。结果表明，为保证用配体交换法制备９９ｍｃ－ＥＣ时９９ｍｃ－ＥＣ的标记率大于９０％，体系的ｐＨ值必须≥８。     

钢铁表面锌系磷化膜的研究

本文采用ＳＥＭ和ＴＥＭ等测试手段，研究了四功能处理液不同条件下在钢铁表面上形成锌系磷化膜的形貌，晶体结构；采用ＥＤＳ研究了磷化膜的化学成发，通过实验确定了Ｚｎ／Ｐ值在２．１２～３．２０时，磷化膜具有良好的耐蚀性。     

宽频带函数波形产生器的研制

本文介绍以ＭＡＸ０３８为基础而研制的宽频带函数波形产生器，它可以产生２￣２×＾７Ｈｚ频率范围的正弦波、三角波、锯齿波和矩形波以及与它们同步的ＴＴＬ脉冲信号。     

网络新闻及其使用

本文介绍了Ｉｎｔｅｒｎｅｔ中网络新闻及其订阅，检查，阅读，消息文件的删除，发送新闻，新闻组的建议以及使用中应注意的事项。     

数字化背景下的网络信息安全管理问题研究

随着网络技术的飞速发展和广泛应用,信息安全问题正日益突出显现出来,受到越来越多的关注。文章介绍了网络信息安全的现状,探讨了网络信息安全的内涵,分析了网络信息安全的主要威胁,最后给出了网络信息安全的实现技术和防范措施,以保障计算机网络的信息安全,从而充分发挥计算机网络的作用。     

Dynex: multiplex ELISA technology

Conventional enzyme-linked immunosorbent assay (ELISA) is a gold standard for screening antibodies and testing for protein or antigen presence. A significant limitation of this assay resides in the fact that only one analyte can be assessed per microplate well. Here, we describe and investigate a new technology consisting of an automated ELISA system in which up to 10 analytes can be measured within one single well, thus improving productivity, accuracy, and repeatability by reducing the amount of human labor required. Another strength of the platform is that a user can load any necessary sets/subsets of beads to perform required assays, with improved flexibility compared to manufactured-loaded arrays for multiplex analysis. We also demonstrate that this system can be used to determine the pathogenicity (i.e., presence of Shiga toxins) and serotype (i.e., Escherichia coli O157) of E. coli isolates.     

嵌入式uClinux的Web服务技术

随着Web技术的发展,嵌入式Web服务器技术在远程管理控制方面得到了广泛的应用。远程监控系统很适合应用Web技术,而嵌入式Web服务器技术作为结合了Web技术和现场工作要求特点的一项新技术,是一种很好的解决方案。     

密云水库第一溢洪道水工大体积商品混凝土温控计算方法与措施研究

密云水库第一溢洪道是洪水期间保证密云水库安全的重要设施,溢洪道闸室段对强度和裂缝限制要求较高.利用经验公式、数值模型2种方法初步计算大体积商品混凝土的温度过程,为现场采取温控措施提供参考,进行浇筑施工并实时测温,然后以现场浇筑情况作为边界条件重新计算,与现场实测结果对比验证;用数值模型进一步分析不同温控措施的敏感性.定量分析结果表明,经验公式计算的外部温度过程比实测偏低,数值模型计算结果与实测相近,建议大型水利工程温度计算尽量采用数值模拟;混凝土最大温升受浇筑温度、冷却水管布置密度的影响较大,冷却结束时的温度受冷却水管布置密度、通水时长、模板导热系数影响较大.裂缝实测结果显示工程制定的浇筑方案合理可行,可以为类似工程提供借鉴.