An efficient weighted trust‐based malicious node detection scheme for wireless sensor networks

The aim of wireless sensor networks (WSNs) is to gather sensor data from a monitored environment. However, the collected or reported information might be falsified by faults or malicious nodes. Hence, identifying malicious nodes in an effective and timely manner is essential for the network to function properly and reliably. Maliciously behaving nodes are usually detected and isolated by reputation and trust‐based schemes before they can damage the network. In this paper, we propose an efficient weighted trust‐based malicious node detection (WT‐MND) scheme that can detect malicious nodes in a clustered WSN. The node behaviors are realistically treated by accounting for false‐positive and false‐negative instances. The simulation results confirm the timely identification and isolation of maliciously behaving nodes by the WT‐MND scheme. The effectiveness of the proposed scheme is afforded by the adaptive trust‐update process, which implicitly performs trust recovery of temporarily malfunctioning nodes and computes a different trust‐update factor for each node depending on its behavior. The proposed scheme is more effective and scalable than the related schemes in the literature, as evidenced by its higher detection ratio (DR) and lower misdetection ratio (MDR), which only slightly vary with the network's size. Moreover, the scheme sustains its efficient characteristics without significant power consumption overheads.     

Optimal joint load balancing and EDCA configuration of IEEE 802.11 wireless hotspots

Wireless hotspots, ie, infrastructures composed of several IEEE 802.11 access points (APs), are today the most common solution in providing Internet access to a wide and rapidly changing population of users. According to common device implementation, stations establish associations with APs based on the measured strongest Received Signal Strength Indicator level. This usually leads to an uneven distribution of users to APs, increasing the chances of local network congestion. Load balancing (LB) solutions aim at mitigating this problem controlling the distribution of users. The LB algorithms enforce stations to associate with APs that manage a low number of users and/or that have a low traffic load. Usually, LB solutions do not consider traffic priorities or they assume some a priori quality of service (QoS) configuration for users. In this study, we propose a QoS‐LB solution based on the cell breathing technique with the goal of balancing the load in IEEE 802.11e Enhanced Distributed Channel Access (EDCA) Hotspots. The proposed algorithm explores the space of possible power/EDCA configurations by using a branch and bound approach that reduces the number of analyzed configurations and, hence, the time required to find the global optimal solution. The algorithm has been analytically defined and its performance evaluated through simulations and tests in a real test bed. The results prove that the proposed solution is effective in solving the optimal QoS‐LB configuration problem in WiFi hotspots of average size.     

Some geotechnical properties of soils in the Haditha area,W. Iraq

The present study is part of the regional engineering geological survey of the western deserts dealing with soil investigations attempting their classification and evaluation for engineering purposes. Field study has revealed that these soils are mainly of residual origin, partly they are colluvial and alluvial. Laboratory test results show that they composed of both coarse and fine fractions. The coarse-grained are mainly of SM-group, less frequently of SC-group. Fine-grained soils are of both CL-and ML groups in equal significance. These soils are seldom free from soluble salts, particularly sulphates in the form of secondary gypsum, some with a high content. Results are discussed in details. Important engineering properties with suitability for engineering use are also given.     

Nanocrystalline diamond--an excellent platform for life science applications

Nanocrystalline diamond (NCD) has recently been successfully utilized in a variety of life science applications. NCD films are favorable and salubrious substrates for cells during cultivation. Therefore NCD has also been employed in tissue engineering strategies. NCD as reported in this contribution was grown by means of a modified hot-filament chemical vapor deposition technique, which results in less than 3% sp2-hybridization and yields grain sizes of 5-20 nm. After production the NCD surface was rather hydrophobic, however it could be efficiently refined to exhibit more hydrophilic properties. Changing of the surface structure was found to be an efficient means to influence growth and differentiation capacity of a variety of cells. The particular needs for any given cell type has to be proven empirically. Yet flexible features of NCD appear to be superior to plastic surfaces which can be hardly changed in quality. Besides its molecular properties, crystal structural peculiarities of NCD appear to influence cell growth as well. In our attempt to facilitate, highly specialized applications in biomedicine, we recently discovered that growth factors can be tightly bound to NCD by mere physisorption. Hence, combination of surface functionalization together with further options to coat NCD with any kind of three-dimensional structure opens up new avenues for many more applications. In fact, high through-put protein profiling of early disease stages may become possible from serum samples, because proteins bound to NCD can now be efficiently analyzed by MALDI/TOF-MS. Given these results, it is to be presumed that the physical properties and effective electrochemical characteristics of NCD will allow tailoring devices suitable for many more diagnostic as well as therapeutic applications.     

Gabapentin-induced coma in a patient with renal failure

We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.     

Effect of different denture adhesives on retention of complete dentures: an in vivo study

The increase in prevalence of tooth loss with the effect of population aging produces the growing need for complete dentures. The success and acceptance of complete dentures by the patient depends on sufficient retention and stability. Therefore, denture adhesives are regularly used by denture wearers to improve the function of complete denture. We evaluated the effect of three different denture adhesives (Corega, Protefix, Fittydent) on the retention of maxillary complete denture (MCD) using with digital dynamometer (DD). For this purpose, denture adhesives were applied on MCDs of 30 participants. After chewing procedure, the force was applied at 45° to the palatal surface of denture by DD. Dislodgement force was recorded by means of Newton. There were four measurements on each patient including; group of control: Group C; Group CR: Corega; Group F: Fittydent; Group P: Protefix. The result of the study was statistically evaluated by using analysis of variance (ANOVA) and Tukey HSD test. Statistics of ANOVA showed a significant difference among all the four groups (p = 0.00, <0.05). Tukey HSD test indicated that there was a statistical difference between Group F and the other groups, but there was not a significant difference between the other groups. The highest adhesive strength value was observed in group F, the lowest in group C. Use of denture adhesives improved the retentive strength of complete denture.     

CAR T Cell Therapy in Hematological Malignancies: Implications of the Tumor Microenvironment and Biomarkers on Efficacy and Toxicity

Chimeric antigen receptor (CAR) T cell therapy has ushered in a new era in cancer treatment. Remarkable outcomes have been demonstrated in patients with previously untreatable relapsed/refractory hematological malignancies. However, optimizing efficacy and reducing the risk of toxicities have posed major challenges, limiting the success of this therapy. The tumor microenvironment (TME) plays an important role in CAR T cell therapy’s effectiveness and the risk of toxicities. Increasing research studies have also identified various biomarkers that can predict its effectiveness and risk of toxicities. In this review, we discuss the various aspects of the TME and biomarkers that have been implicated thus far and discuss the role of creating scoring systems that can aid in further refining clinical applications of CAR T cell therapy and establishing a safe and efficacious personalised medicine for individuals.     

Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma

Simple SummaryMembrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoint blocker, enhancing the function of NK cells on target human MM cell lines and primary cells.AbstractMultiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro the expression and function of PCNA on MM cells. First, we show that PCNA is present on the cell membrane of five out of six MM cell lines, using novel anti-PCNA mAb developed to recognize membrane-associated PCNA. Next, we stained primary bone marrow (BM) mononuclear cells from MM patients and showed significant staining of membrane-associated PCNA in the fraction of CD38⁺CD138⁺ BM cells that contain the MM cells. Importantly, blocking of the membrane PCNA on MM cells enhanced the activity of NK cells, including IFN-γ-secretion and degranulation. Our results highlight the possible blocking of the NKp44-PCNA immune checkpoint by the mAb 14-25-9 antibody to enhance NK cell responses against MM, providing a novel treatment option.