Optimization of the gain-bandwidth product of capacitive micromachined ultrasonic transducers

Capacitive micromachined ultrasonic transducers (cMUT) have large bandwidths, but they typically have low conversion efficiencies. This paper defines a performance measure in the form of a gain-bandwidth product and investigates the conditions in which this performance measure is maximized. A Mason model corrected with finite-element simulations is used for the purpose of optimizing parameters. There are different performance measures for transducers operating in transmit, receive, or pulse-echo modes. Basic parameters of the transducer are optimized for those operating modes. Optimized values for a cMUT with silicon nitride membrane and immersed in water are given. The effect of including an electrical matching network is considered. In particular, the effect of a shunt inductor in the gain-bandwidth product is investigated. Design tools are introduced, which are used to determine optimal dimensions of cMUTs with the specified frequency or gain response.     

On efficient construction and evaluation of runs rules–based control chart for known and unknown parameters under different distributions

In this study, we have considered two design structures of control chart by covering the situations of known and unknown parameters, variety of probability distributions, and runs rules. The design structures are dependent on constants which generally considered hard to compute analytically. For construction of constants and also for evaluating performance of the design structures through performance measures, we have illustrated Monte Carlo simulation procedure/algorithm for researcher and practitioners. Furthermore, based on the Monte Carlo simulation procedures, we have established a program in R language to compute values of different constants and performance measures. Results illustrated that design structures for known and unknown parameters under variety of runs rules and probability distributions have outstanding performance in contrast to existing structures. Moreover, design structure for unknown parameters behaves alike the design structure for known parameters. This indicates that design structure for unknown parameters has the ability to resolve the issue of runs rules which generally occur when parameters are estimated. Besides, two real‐life examples have been included in which physicochemical characteristic of groundwater and plasticizer characteristic of petrochemical process are monitored through design structures.     

Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques

The purpose of the present study was to investigate, by MRI and histochemical techniques, the diffusion and clearance abilities of superparamagnetic iron oxide nanoparticles (SPION) coated with dextran (Dextran-SPION) and gold (Au-SPION) following their local infusions into the rat brain. In separate groups of anesthetized rats, the Dextran-SPION and Au-SPION were infused at concentrations of 0.01, 0.1, 1 and 5 μg Fe/0.5 μl and at the flow rate of 0.5 μl min(-1) into the left and right striata, respectively. Repetitive T2-weighted spin-echo MRI scans were performed at time intervals of 1, 6, 12, 24, 48, 72 h, and one, two and eight weeks after inoculation. Following infusion of Dextran-SPION (0.1 μg and 1 μg Fe), the maximal distribution volume was observed at about 12-24 h after inoculation and two weeks later the Fe signals were undetectable for the lower dose. On the other hand, Au-SPION remained tightly localized in the closest vicinity of the infusion site as revealed by unchanged MRI signal intensities and strong histochemical staining of Fe(2+) and Fe(3+) ions in the corresponding brain slices. Immunohistochemical staining of astrocytic and microglial reactions revealed that there were no marked differences in GFAP, VIM or OX-42 labeling observed between the nanoparticle types, however the astrocytic reaction was more pronounced in rats receiving nanoparticles compared to the control (aCSF-infused) rats. In conclusion, the present data demonstrate that the viral-sized Dextran-SPION were able to diffuse freely through the interstitial space of the brain being progressively cleared out from the infusion site within two weeks. Thus, Dextran-SPION could be beneficially used in MRI-guided diagnostic applications such as in experimental oncology or as labels and carriers for targeted drug delivery, whereas Au-SPION could be used for labeling and tracking the transplanted stem cells in experimental MRI.     

TRACER RESPONSE IN PARTIALLY FRACTURED RESERVOIRS

There is considerable interest in the petroleum industry to characterize partially fractured reservoirs and to develop an increased understanding of the physics of fluid flow in these types of reservoirs. This is because fractured reservoirs have different behavior and there exist a large number of these reservoirs that are not fully developed. This paper presents a numerical simulation study that was performed to investigate the effect of rock properties on the tracer response in partially fractured reservoirs using a finite difference numerical simulator. These properties include fracture intensity, fracture porosity and matrix permeability. The functional relationships between these parameters and the calculated effective permeabilities are also investigated. Several images, each with different probability of fracture intensity, were generated randomly. Numerical simulations of single-phase tracer transport were then performed in each of the generated fractured models. Results show that the fracture intensity, fracture porosity and matrix permeability have a significant effect on the tracer response in naturally fractured reservoirs. Depending on the reservoir properties, the results also show that the flow in partially fractured reservoirs can be either matrix-dominated or fracture-dominated. The characteristics of each regime and the conditions for its occurrence are presented.     

Forced Commutated Cycloconverters for High-Frequency Link Applications

Forced commutated cycloconverters (FCC's) have been used successfully as static frequency changers for low-to-medium frequency applications. The use of FCC's for high-frequency applications and, in particular, in the role of high-frequency links (HFL's) is investigated. Such links are widely used as intermediate stage circuits to provide simultaneous power conditioning and ohmic isolation. The investigation shows that suitable HFL circuit topologies do exist for any combination of input-to-output number of phases. It also shows that, through the use of appropriate switching techniques, it is possible to obtain HFL output voltage and input current waveforms with low harmonic content and insignificant amplitude derating.     

Time-interleaved SAR ADC design with background calibration

In this article, a low power time-interleaved SAR (TI-SAR) ADC is presented. Background calibration is used to improve the linearity of the ADC. Offset, gain, and capacitor mismatches between interleaved channels are calibrated by postprocessing the ADC output. Besides, a novel trimming-based calibration algorithm is used to calibrate the timing mismatches between channels. The proposed calibration algorithm is more power-efficient compared with most of its counterparts. The ADC consists of 18 parallel channels, a reference channel with two dummy channels, and a channel for timing calibration. The timing calibration channel is clocked only when the reference channel samples. The dummy channels are utilized to equalize the input load over time as they sample one after another to fill the gap where the reference channel does not sample. There is no need for any other dummy channels for timing calibration channel since it has low kickback noise over input driver. Each parallel channel operates at 111 ms/s while the reference channel runs at 105 ms/s. The aggregate sampling speed of the converter is 2 GS/s, and 52-dB SNDR is accomplished near Nyquist frequencies.     

Two distinct fluorescent quantum clusters of gold starting from metallic nanoparticles by pH-dependent ligand etching

Two fluorescent quantum clusters of gold, namely Au₂₅ and Au₈, have been synthesized from mercaptosuccinic acid-protected gold nanoparticles of 4–5 nm core diameter by etching with excess glutathione. While etching at pH ∼3 yielded Au₂₅, that at pH 7–8 yielded Au₈. This is the first report of the synthesis of two quantum clusters starting from a single precursor. This simple method makes it possible to synthesize well-defined clusters in gram quantities. Since these clusters are highly fluorescent and are highly biocompatible due to their low metallic content, they can be used for diagnostic applications. Electronic Supplementary Material  Supplementary material is available for this article at and is accessible for authorized users. This article is published with open access at Springerlink.com     

Tailored magnetic nanoparticles for direct and sensitive detection of biomolecules in biological samples

We developed nanoparticles with tailored magnetic properties for direct and sensitive detection of biomolecules in biological samples in a single step. Thermally blocked nanoparticles obtained by thermal hydrolysis, functionalized with specific ligands, are mixed with sample solutions, and the variation of the magnetic relaxation due to surface binding is used to detect the presence of biomolecules. The binding significantly increases the hydrodynamic volume of nanoparticles, thus changing their Brownian relaxation frequency which is measured by a specifically developed AC susceptometer. The system was tested for the presence of Brucella antibodies, a dangerous pathogen causing brucellosis with severe effects both on humans and animals, in serum samples from infected cows and the surface of the nanoparticles was functionalized with lipopolysaccharides (LPS) from Brucella abortus. The hydrodynamic volume of LPS-functionalized particles increased by 25-35% as a result of the binding of the antibodies, measured by changes in the susceptibility in an alternating magnetic field. The method has shown high sensitivity, with detection limit of 0.05 microg x mL(-1) of antibody in the biological samples without any pretreatment. This magnetic-based assay is very sensitive, cost-efficient, and versatile, giving a direct indication whether the animal is infected or not, making it suitable for point-of-care applications. The functionalization of tailored magnetic nanoparticles can be modified to suit numerous homogeneous assays for a wide range of applications.