Characterization of the absorption of theophylline from immediate- and controlled-release dosage forms with a numerical approach using the in vitro dissolution-permeation process using caco-2 cells

After oral administration, drug absorption rate is recognized to be dependent on two major factors: dissolution and intestinal cells permeability. Caco-2 monolayer cells have been largely used as a permeation study model. In this study, a numerical approach funded on an exponential first-order time relationship was tested to compare immediate- and controlled-release tablets of theophylline using a dissolution-permeation system. The dissolution performance using USP II paddle apparatus was coupled to the permeability studies investigated in Caco-2 cell monolayers. The dissolved samples were taken at different times; their pH and osmolarity were adjusted to render them suitable to Caco-2 permeability studies (osmolarity = 300 mosm, pH = 7.4). The experimental data show that the dissolution fits the exponential first-order relationship rate. The permeability values were in a range of 4.45 10(- 6)-5.28 10(- 6) cm/s, and percentages of absorbed drug dose were dependent on the fraction initially present in the donor compartment, indicating that absorption of theophylline was dissolution rate limited. Plotting experimental absorbed fractions (F(a)) against experimental dissolved fractions (F(d)) show that permeation is the rate-limiting step in drug absorption process in the extended release form of theophylline. Our results demonstrate a general agreement between observed F(a)/F(d) relationships and theoretical F(a)/F(d) relationships obtained with our approach funded on dissolution and permeation behavior. We concluded that the couple dissolution-caco-2 system could be a useful tool to characterize intestinal permeation for a new formulation of a drug compared with the conventional one.     

Adaptive modulation and combining for bandwidth and power efficient communication over fading channels

Traditional fading mitigation techniques are designed relative to the worst‐case channel conditions, resulting in a poor utilization of the spectrum and the available power a good percentage of the time. In contrast, we introduce and investigate in this paper new adaptive modulation and diversity combining techniques that jointly select the most appropriate constellation size and the most suitable diversity branches in response to the channel variation and given a desired bit error rate (BER) requirement. Numerical results show that these newly proposed adaptive modulation and combining schemes can reduce considerably the average receiver channel estimation complexity as well as the power drain from the battery while offering high spectral efficiency and satisfying the desired outage probability and BER requirements. Copyright © 2006 John Wiley & Sons, Ltd.     

Mechanical Properties Analysis of 4340 Steel Specimen Heat Treated in Oven and Quenching in Three Different Fluids

This paper proposes a statistical approach to analyze the mechanical properties of a standard test specimen, of cylindrical geometry and in steel 4340, with a diameter of 6 mm, heat-treated and quenched in three different fluids. Samples were evaluated in standard tensile test to access their characteristic quantities: hardness, modulus of elasticity, yield strength, tensile strength and ultimate deformation. The proposed approach is gradually being built (a) by a presentation of the experimental device, (b) a presentation of the experimental plan and the results of the mechanical tests, (c) anova analysis of variance and a representation of the output responses using the RSM response surface method, and (d) an analysis of the results and discussion. The feasibility and effectiveness of the proposed approach leads to a precise and reliable model capable of predicting the variation of mechanical properties, depending on the tempering temperature, the tempering time and the cooling capacity of the quenching medium.     

Mechanical investigation of tunnels: risk analysis and notation system

The current mechanical investigation strategy applied to RATP (Régie Autonome des Transpots Parisiens) tunnels is mainly based on visual inspection. All the works are inspected and every apparent fault is located and reported in inspection reports. However, this type of inspection detects only apparent faults without linking them to their causes. A new methodology of mechanical investigation is proposed in the framework of the ANR project MEDITOSS (Méthodologie de Diagnostic des Tunnels et Ouvrages Souterrains en Service), consisting in integrating mechanical investigation tools to better characterise the geometrical and mechanical state of the tunnel. This new strategy combines four techniques (ground penetrating radar, light dynamic penetrometer, endoscopy and geo-mechanical impedance). These techniques are applied to panels to obtain a ‘panel score’. This paper presents a risk analysis of the system studied (network of corridors and tunnels), by applying the bow-tie method in order to obtain information on its elements, its function and its pathologies. This analysis incorporates a quantitative characterisation method (scoring) to assess the state of corridors and tunnels. These methods are tested on infiltration and cracking pathologies for the risk analysis and on the notation of a corridor for the quantitative quantification.     

LED发光式LAN电缆测试器

电缆与连接器故障在LAN(局域网)中相对较常见。图1的电路可以测试直通或交叉式10BaseT、100BaseT或千兆位UTP(非屏蔽双绞线)和STP(屏蔽双绞线)电缆。电路会对每个链接线对作一次连续测试。当电缆两端RJ-45连接器的相应线对正确连     

Benzene hydrogenation over Ni-Cu/SiO2 catalysts prepared by aqueous hydrazine reduction

Non conventional nickel (1%) and nickel (1%)-copper (0.2%-0.75%) catalysts supported on silica have been prepared by aqueous hydrazine reduction of nickel acetate at 70 °C. They were characterized by TEM, H₂-adsorption, H₂-TPD and tested in the gas phase hydrogenation of benzene at atmospheric pressure in the temperature range 75 °C-230 °C. The obtained results show that nickel is in a whisker-like shape or as a film of low density for the Ni/SiO₂ and Ni-Cu/SiO₂ catalysts respectively. Copper is in the shape of facetted particles in the mono or bimetallic systems with a mean particle size varying from 25 to 100 nm. The presence of copper decreased the nickel phase dispersion as well as the conversion whereas it increased carbon deposit in benzene hydrogenation. The results obtained are ascribed to nickel phase shape changes and Ni-Cu interactions. A kinetic reaction mechanism model is proposed. The comparative study of a pair of classical/non-classical Ni/SiO₂ catalysts showed much higher surface and catalytic properties of the hydrazine catalyst.     

Comparative study of various methods for extraction of multi- quantum wells Schottky diode parameters

In this work, forward current voltage characteristics for multi-quantum wells Al_0.33Ga_0.67As Schottky diode were measured at temperature ranges from 100 to 300 K. The main parameters of this Schottky diode, such as the ideality factor, barrier height, series resistance and saturation current, have been extracted using both analytical and heuristics methods. Differential evolution (DE), particle swarm optimization (PSO) and artificial bee colony (ABC) have been chosen as candidate heuristics algorithms, while Cheung technic was selected as analytical extraction method. The obtained results show clearly the high performance of DE algorithms in terms of parameters accuracy, convergence speed and robustness.