油包水钻井液稳定性影响因素分析

采用破乳电压法,分析了配制钻井液过程中影响体系稳定性的因素。结果表明,高强度的搅拌和合理的加料方式有利于提高乳状液稳定性。白油基钻井液比柴油基钻井液具有更高的稳定性,内相中的CaCl2和NaCl能提高体系稳定性。乳化剂的选择是提高乳状液稳定性的关键,应优先选择复配型乳化剂,并综合考虑其HLB值、分子结构以及分子特性。随油量的减少,乳状液的稳定性下降。有机土等处理剂的加入则能有效提高体系稳定性。     

标准化最小距离判别法及其对水流挟沙力公式的检验

在评述水流挟沙力公式检验方法的基础上,以样本距离为基础,提出标准化最小距离判别法,将挟沙力公式检验资料转化到同一数量级,消除检验资料数值差异过大引起的误差,定量评价不同水流挟沙力公式.采用该方法分别对适用于中、低含沙量浓度的12组挟沙力公式和适用于高、中、低含沙量浓度的6组挟沙力公式进行了检验.结果表明:文中选取的水流挟沙力公式均能反映实际挟沙力的变化趋势;其中,张红武公式在不同含沙量浓度情况下均与实际最接近.     

天祝天堂乡科拉一带社火调查

古老的土地与火的崇拜,产生了祭祀社与火的风俗。随着社会的发展,人们认识能力的提高,这项源于祭祀的活动,成为在中华民族新年闹春的传统节日中规模盛大、内容繁富的民间娱乐活动。着眼于甘肃省天祝县天堂乡科拉一带的社火,对其整体形态及表演中演唱的社火调加以梳理和描述。     

1‐Arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

A series of 1‐arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines ( 7 – 15 ) has been developed; the compounds exhibited potent histone deacetylase (HDAC) inhibitory activities. Notably, almost all of this series exhibited better HDAC‐inhibitory and antiproliferative activities than 3‐(1‐benzenesulfonyl‐1H‐indol‐5‐yl)‐N‐hydroxyacrylamide ( 6 ), as reported in a previous study. Among these compounds, 3‐[1‐(4‐methoxybenzenesulfonyl)‐2,3‐dihydro‐1H‐indol‐5‐yl]‐N‐hydroxyacrylamide ( 9 ) showed a two‐ to tenfold increase in activity compared to SAHA ( 1 ) in the suppression of lipopolysaccharide‐induced cytokine production. Compound 9 also caused a marked reduction in carrageenan‐induced acute inflammation in a rat model. Taken together, these data indicated that 1‐arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines HDAC inhibitors exhibit potent anti‐inflammatory activity.     

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline reduces glial loss and acute white matter pathology after experimental spinal cord contusion

Focal microinjection of 2, 3-dihyro-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX), an antagonist of the AMPA/kainate subclass of glutamate receptors, reduces neurological deficits and tissue loss after spinal cord injury. Dose-dependent sparing of white matter is seen at 1 month after injury that is correlated to the dose-related reduction in chronic functional deficits. To determine whether NBQX exerts an acute effect on white matter pathology, female, adult Spague Dawley rats were subjected to a standardized weight drop contusion at T-8 (10 gm x 2.5 cm) and NBQX (15 nmol) or vehicle (VEH) solution focally injected into the injury site 15 min later. At 4 and 24 hr, tissue from the injury epicenter was processed for light and electron microscopy, and the histopathology of ventromedial white matter was compared. The axonal injury index, a quantitative representation of axoplasmic and myelinic pathologies, was significantly lower in the NBQX group at 4 hr (2.7 +/- 0.24, mean +/- SE) and 24 hr (1.4 +/- 0.19) than in VEH controls (3.8 +/- 0.33 and 2.1 +/- 0.20, respectively). Counts of glial cell nuclei indicated a loss of at least 60% at 4 and 24 hr after injury in the VEH group compared with uninjured controls. NBQX treatment reduced this glial loss by half. Immunohistochemistry revealed that the spared glia were primarily oligodendrocytes. Thus, the chronic effects of NBQX in reducing white matter loss after spinal cord injury appear to be attributable to the reduction of acute pathology and may be mediated through the protection of glia, particularly oligodendrocytes.     

塑料包装成型机械及其导柱的受力分析

对包装工程中常用的塑料加工机械，如液压机，中空吹塑机，注塑机等的结构和使用范围进行了简要的介绍，并对这些机械中的主要部件”导柱的受力情况进行了分析，列出了强度的验算公式，分析了导柱在使用中容易出现断裂的原因及补救的方法。     

浅谈大型设备桩基础的设计

对桩基础在工业厂房设备基础设计中值得注意的问题进行讨论.     

薄壁铸件不明夹杂物缺陷成因的微观分析

通过扫描电镜分析了薄壁铸件不明夹杂物缺陷的成因.分析结果表明,夹杂物为涂料夹杂和氧化夹渣.提出采用优质涂料、适当减小涂层厚度、降低锰合金粒度等措施,铸件夹杂物缺陷已大幅度减少.