Neural networks,rational functions,and realization theory

The problem of parametrizing single hidden layer scalar neural networks with continuous activation functions is investigated. A connection is drawn between realization theory for linear dynamical systems, rational functions, and neural networks that appears to be new. A result of this connection is a general parametrization of such neural networks in terms of strictly proper rational functions. Some existence and uniqueness results are derived. Jordan decompositions are developed, which show how the general form can be expressed in terms of a sum of canonical second order sections. The parametrization may be useful for studying learning algorithms.This work was supported by the Australian Research Council, the Australian Telecommunications and Electronics Research Board, and the Boeing Commencai Aircraft Company (thanks to John Moore).     

Memory for individual scent in hamsters (Mesocricetus auratus) as assessed by habituation methods.

The memory of hamsters (Mesocricetus auratus) for the flank scent of older male hamsters was investigated in a series of habituation experiments. In 2 types of habituation tasks (Exps 1 and 2), male hamsters habituated to the flank scent of 1 male and then increased their level of investigation to that of a novel male; similar results were obtained when the intervals between trials ranged from 1 sec to 2 days. When the test trial was 10 or 21 days after habituation (Exp 3), males discriminated between familiar and novel flank scents at 10 days but not at 21 days. The results demonstrate recognition of familiar and unfamiliar individual odors and excellent memory for these differences. Habituation techniques yield extremely robust results and may be useful for investigations of other aspects of individual signatures. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Early intervention for spelling problems: Teaching functional spelling units of varying size with a multiple-connections framework.

Poor spellers in 2nd grade (n?=?128) participated in 24 20-min sessions that included (a) direct instruction in the alphabet principle (most frequent phoneme-spelling connections); (b) modeling of different approaches, singly and in combination, for developing connections between spoken and written words for 48 words ordered by sound-spelling predictability; and (c) practice in composing. Results of this multilayered intervention showed that (a) more than 1 way of developing sound-spelling connections is effective in teaching spelling but that after training in the alphabet principle, combining whole word and onset-rime training is most effective in achieving transfer of the alphabet principle across word contexts; (b) functional spelling units of not only a single letter but also 2 or more letters are important in beginning spelling; and (c) training in spelling transfers to composition and word recognition. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Maintaining global coherence during reading.

Previous research demonstrated a contradiction effect: Although text currently being processed was locally coherent, readers were aware of inconsistencies between a protagonist's actions and characteristics of the protagonists that were described earlier in the text and subsequently backgrounded. In the present experiments, not only the critical characteristics but also the protagonist were backgrounded. When the protagonist was reintroduced into the narrative in the context of carrying out an inconsistent action, the contradiction effect again occurred. In Exps 1–3, we examined the effects of several variables on the onset of the effect. In Exp 4, we presented probes at various points in the passage with results that supported the conclusion that the critical characteristics had been backgrounded before the sentence that contradicted them. Results are discussed in terms of several recent models in which currently active representational elements serve as retrieval cues for other inactive, but highly related, elements. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Automatic generation of IDEF0 models

This paper looks into a new area for knowledge-based system application, that of manufacturing modelling. Manual generation of IDEF0 models of manufacturing systems is time-consuming and inconsistent. However, the process can be automated to improve timeliness and consistency. In this paper, a knowledge-based manufacturing modelling system for the automatic generation of IDEF0 models is proposed. The system will not only greatly reduce the IDEF0 modelling time but will also eliminate the inconsistency problem of conventional IDEF0 modelling systems. The paper explains the knowledge-based approach and identifies the kinds of domain knowledge that are required for the construction of the knowledge-based manufacturing modelling system.     

Analysis and simulation of substrate coupling in integrated circuits

A technique is presented which allows efficient calculation of substrate-coupling macromodels in integrated circuits. the technique can be used to calculate node-to-node resistances or impedances in substrate models. Examples of the technique applied to several test structures are presented.     

Direct monitoring of the calcium concentration in the sarcoplasmic and endoplasmic reticulum of skeletal muscle myotubes

Direct monitoring of the free Ca2+ concentration in the sarcoplasmic reticulum (SR) was carried out in rat skeletal myotubes transfected with a specifically targeted aequorin chimera (srAEQ). Myotubes were also transfected with a chimeric aequorin (erAEQ) that we have demonstrated previously is retained in the endoplasmic reticulum (ER). Immunolocalization analysis showed that although both recombinant proteins are distributed in an endomembrane network identifiable with immature SR, the erAEQ protein was retained also in the perinuclear membrane. The difficulty of measuring [Ca2+] in 100-1000 microM range was overcome with the use of the synthetic coelenterazine analogue, coelenterazine n. We demonstrate that the steady state levels of [Ca2+] measured with srAEQ is around 300 microM, whereas that measured with erAEQ is significantly lower, i.e. around 200 microM. The effects of caffeine, high KCl, and nicotinic receptor stimulation, in the presence or absence of external calcium or after blockade of the Ca-ATPase, were investigated with both chimeras. The kinetics of [Ca2+] changes revealed by the erAEQ were similar, but not identical, neither quantitatively nor qualitatively, to those monitored with the srAEQ, indicating that at this stage of muscle development, differences exist between SR and ER in their mechanisms of Ca2+ handling. The functional implications of these findings are discussed.     

Vascular aging. Role of elastin receptor

A distinction is made between atheromatous plaque formation and arteriosclerosis, only this second process is strictly age-dependent. Interactions between lipids and constituents of the vascular wall are however involved in both processes, although by different mechanisms. The progressive increase with age of elastase activity is a second important factor in the age-dependent progression of arteriosclerosis. The fragmentation of elastic fibers produces elastin peptides, present in the circulating blood in microgram/ml conc-s, increasing in several arteriopathies. The constant presence of elastin peptides in the circulation maintains activated the elastin receptor (16) on endothelial cells producing NO* with vasorelaxing activity (18). The simultaneous production of superoxyde leads to the formation of peroxynitrate, neutralized by reduced glutathion. This process, maintained over decades may well impair the antiradical defense mechanisms of the cells and deprive the endothelium from the vasorelaxing activity of NO*. We propose therefore that the maintained activation of the elastin receptor with free radical and lytic enzyme production might well represent the initiating process underlying atherogenesis.