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21.
This paper is focused on designing a distributed adaptive control scheme for a vehicular platoon with unknown bounded velocity/acceleration disturbances and unknown nonlinear dead‐zone inputs. Our aim is to design distributed adaptive controllers based on integral sliding mode control techniques that guarantee practical exponential convergence (i.e., exponential stability of an arbitrarily small neighborhood of zero) of the spacing errors and the string stability of the whole vehicular platoon. The contributions of this paper are that: (i) based on a modified constant time headway policy, the whole vehicular platoon is guaranteed to have string stability despite dead zone inputs; (ii) adaptive compensation terms are constructed to compensate for the time‐variant effects caused by unknown bounded velocity/acceleration disturbances, and unknown dead zone inputs; (iii) an efficient numerical method for avoiding the singularity problem of the control law is also proposed. Numerical simulation results show the validity and advantages of the proposed method are significantly higher traffic density and string stability. Copyright © 2016 John Wiley & Sons, Ltd.  相似文献   
22.
Examined the graduate school origins of authors of Journal of Counseling Psychology (JCP) articles in Volumes 15–28 to extend a previous analysis of Volumes 1–24 by the 3rd author et al (1969). Comparisons of the 2 14-yr periods reveal that some universities retained the same or similar ranks across both periods, some declined in importance as sources of authors, and others emerged as major sources of JCP authors. (6 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
23.
This paper presents an overview of the image analysis techniques in the domain of histopathology, specifically, for the objective of automated carcinoma detection and classification. As in other biomedical imaging areas such as radiology, many computer assisted diagnosis (CAD) systems have been implemented to aid histopathologists and clinicians in cancer diagnosis and research, which have been attempted to significantly reduce the labor and subjectivity of traditional manual intervention with histology images. The task of automated histology image analysis is usually not simple due to the unique characteristics of histology imaging, including the variability in image preparation techniques, clinical interpretation protocols, and the complex structures and very large size of the images themselves. In this paper we discuss those characteristics, provide relevant background information about slide preparation and interpretation, and review the application of digital image processing techniques to the field of histology image analysis. In particular, emphasis is given to state-of-the-art image segmentation methods for feature extraction and disease classification. Four major carcinomas of cervix, prostate, breast, and lung are selected to illustrate the functions and capabilities of existing CAD systems.  相似文献   
24.
The structural integrity and damage tolerance of typical composite T-joints found in ships constructed from glass fibre reinforced plastic was the subject of this investigation. The effect of the geometry of the T-joint on the strain distribution was investigated using finite element (FE) analysis. The results, reported in this paper, showed that the critical strains were significantly affected by the joint geometry. Results of the FE analysis conducted to investigate the effect of disbonds between the filler and overlaminate are also reported. This showed that particular defects led to large changes in the strains in the T-joint structure, which would encourage disbond progression. The FE model was validated by mechanical tests on a representative T-joint, instrumented with surface strain gauges and displacement transducers, into which a range of defects was progressively introduced.  相似文献   
25.
The aim of this paper is to explore the transition from traditional measures to creativity and innovation measures within a number of small to medium‐sized enterprises (SMEs) case studies. The need for increased competitiveness has created an impetus for increased creativity and innovation in SMEs. However, the measures associated with the process of creativity and innovation in organisations sometimes do not follow cause‐and‐effect rationale, reflecting non‐linear behaviour. A multiple SME‐based case research methodology is used to explore the transitioning effects from traditional to more creativity and innovation based measures. The cases were part of a longitudinal creativity and innovation intervention programme, which combined taught modules and Critical Action Learning networks over a two‐year period. These networks involved sub‐groups applying critical theory‐based study to the learning they had received in the modules. The findings reveal that the transition dynamics include a complex mix of cause and effect rationale, phenomenology, incremental change, radical change, quantitative, qualitative and linear and complex contrasts and comparisons. Thus, managers must facilitate an eclectic approach to creativity and innovation measures.  相似文献   
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Water Resources Management - Diversified water supply schemes can reduce both peak demand and overall demand in the urban water supply network. Consequently, they provide benefits to both the water...  相似文献   
29.
Ubiquitin-like proteins (Ubls) confer diverse functions on their target proteins. The modified proteins are involved in various biological processes, including DNA replication, signal transduction, cell cycle control, embryogenesis, cytoskeletal regulation, metabolism, stress response, homeostasis and mRNA processing. Modifiers such as SUMO, ATG12, ISG15, FAT10, URM1, and UFM have been shown to modify proteins thus conferring functions related to programmed cell death, autophagy and regulation of the immune system. Putative modifiers such as Domain With No Name (DWNN) have been identified in recent times but not fully characterized. In this review, we focus on cellular processes involving human Ubls and their targets. We review current progress in targeting these modifiers for drug design strategies.  相似文献   
30.
The reversible oxidation of methionine residues in proteins has emerged as a biologically important post-translational modification. However, detection and quantitation of methionine sulfoxide in proteins is difficult. Our aim is to develop a method for specifically derivatizing methionine sulfoxide residues. We report a Pummerer rearrangement of methionine sulfoxide treated sequentially with trimethylsilyl chloride and then 2-mercaptoimidazole or pyridine-2-thiol to produce a dithioacetal product. This derivative is stable to standard mass spectrometry conditions, and its formation identified oxidized methionine residues. The scope and requirements of dithioacetal formation are reported for methionine sulfoxide and model substrates. The reaction intermediates have been investigated by computational techniques and by 13C NMR spectroscopy. These provide evidence for an α-chlorinated intermediate. The derivatization allows for detection and quantitation of methionine sulfoxide in proteins by mass spectrometry and potentially by immunochemical methods.  相似文献   
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