Bufalin Inhibits Tumorigenesis,Stemness, and Epithelial–Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis

Colorectal cancer (CRC) is a major source of morbidity and mortality, characterized by intratumoral heterogeneity and the presence of cancer stem cells (CSCs). Bufalin has potent activity against many tumors, but studies of its effect on CRC stemness are limited. We explored bufalin’s function and mechanism using CRC patient-derived organoids (PDOs) and cell lines. In CRC cells, bufalin prevented nuclear translocation of β-catenin and down-regulated CSC markers (CD44, CD133, LGR5), pluripotency factors, and epithelial–mesenchymal transition (EMT) markers (N-Cadherin, Slug, ZEB1). Functionally, bufalin inhibited CRC spheroid formation, aldehyde dehydrogenase activity, migration, and invasion. Network analysis identified a C-Kit/Slug signaling axis accounting for bufalin’s anti-stemness activity. Bufalin treatment significantly downregulated C-Kit, as predicted. Furthermore, overexpression of C-Kit induced Slug expression, spheroid formation, and bufalin resistance. Similarly, overexpression of Slug resulted in increased expression of C-Kit and identical functional effects, demonstrating a pro-stemness feedback loop. For further study, we established PDOs from diagnostic colonoscopy. Bufalin differentially inhibited PDO growth and proliferation, induced apoptosis, restored E-cadherin, and downregulated CSC markers CD133 and C-Myc, dependent on C-Kit/Slug. These findings suggest that the C-Kit/Slug axis plays a pivotal role in regulating CRC stemness, and reveal that targeting this axis can inhibit CRC growth and progression.     

分布式多参数光纤传感技术研究进展

分布式光纤传感系统利用光纤既能传感又能传输信号的特性实现对光纤沿线振动、应变、温度等物理量的长距离连续测量,在周界安防、电网管道监控、大型结构健康监测等领域具有十分广阔的应用前景。上述的实际应用中,事件或故障的发生通常表现为振动、应变以及温度等物理量的改变,振动的探测频响高低、应变探测的动态响应能力以及多参数的同时测量都会影响事件的定位或预警。因此,振动的宽频测量、应变的动态测量以及多参数测量,对事件定位和信息完整捕获起着至关重要的作用,能够推动分布式光纤传感的应用发展。本文介绍了近年来在分布式光纤传感系统中,基于瑞利散射的宽频振动测量、基于布里渊散射的应变动态测量以及基于多散射的多参数测量取得的研究进展。

     

SecMVX:Analysis on the Vulnerability of Multi-Variant Execution

As an active defenses technique, multi-variant execution(MVX) can detect attacks by moni-toring the consistency of heterogeneous variants with parallel executio...     

复杂过程分析的模糊聚类分类器设计及其性能

本文采用模式识别方法推断烧结矿质量。在给出模糊系统聚类分析算法基础上,用软件实现了基于模糊聚类分类器和动态聚类分类器,并用现场实测的样本采用\     

Synthesis and electromagnetic transport of large-area 2D WTe2 thin film

Tungsten telluride thin films were successfully prepared on monocrystal sapphire substrates by using atomic layer deposition and chemical vapor deposition technology, and the effects of different tellurization temperatures on the properties of tungsten telluride films were investigated. The growth rate, crystal structure and composition of the film samples were characterized and analyzed by using scanning electron microscope, Raman spectroscopy and X-ray photoelectron spectroscopy. The results showed that tungsten telluride thin films with good crystal orientation in (001) were obtained at telluride temperature of 550 °C. When the telluride temperature reached 570 °C, the tungsten telluride began to decompose and unsaturated magnetoresistance was found.     

土壤腐蚀性关键因素的评价与选取

在22种土壤腐蚀性因素的聚类分析的基础上,通过对单个因素分类能力的特征评价,从同类中选取关键性因素,进而在特征空间中进行有关样本的土壤腐蚀性预测和考评,为今后土壤腐蚀性研究中主要因素的选取和等级评判提供一定的依据。     

材料大气腐蚀数据库应用软件的研制

从材料大气腐蚀数据库应用系统如何在IBM/PC-XT计算机上实现的角度,介绍它的机器环境和系统构成,详细地叙述了该系统的应用程序。该系统的优点是操作方便,容易掌握。它的应用对实现全国大气腐蚀试验站的管理科学化具有重要意义。     

Consequence calculation for relocation after nuclear accidents

This paper presents the results of dose and cost calculation for relocation after nuclear accidents. In order to quantify the relationship between radiation dose and relevant parameters defining protective actions, well-designed calculations have been performed and the results analyzed. On the basis of this, some dependencies between the important parameters describing the features of relocation and decontamination have been mathematically formulated. The similar has also been done for some economic costs as a result of implementing the countermeasures considered in this paper.     

LED环氧树脂封装材料研究进展

针对封装材料在使用中的缺陷,综述了对环氧树脂的增韧、提高耐热性、改善透明性、改善加工性能的研究现状,并介绍了LED环氧树脂封装材料的发展前景。