Mild hypothermia: therapeutic window after experimental cerebral ischemia

The treatment of cerebral ischemia remains a formidable challenge in neuroscience today. Mild hypothermia has been shown to be an effective neuroprotective agent. Despite the great volume of published research, the therapeutic window of mild hypothermia has not been precisely elucidated. Using a model of reversible focal cerebral ischemia in the rat, this study was undertaken to define the optimal duration of hypothermic application and the maximal postischemic delay in hypothermic application before which optimal therapeutic effect is noted. Focal ischemia was induced by temporary occlusion of the middle cerebral artery and both carotid arteries in Sprague-Dawley rats for a period of 3 hours. In the first study, mild hypothermia (32-33 degrees C) was induced at the onset of ischemia in four groups of rats for varying lengths of time ranging from 1 to 4 hours. The animals were killed after 3 days, and their brains were sliced and stained. Infarcted volume was measured using a computerized image analyzer. The infarct volumes were 211 +/- 4.5, 214.2 +/- 8.0, 199.5 +/- 5.3, 171.3 +/- 9.1, and 169.8 +/- 6.5 mm3 (mean +/- standard error of the mean, n = 6 per group) for the control, 1-hour, 2-hour, 3-hour, and 4-hour groups, respectively. On the basis of the results from the above study, a 3-hour duration of hypothermia was then applied to animals at 0, 15, 30, or 45 minutes after the ischemic onset. The volumes of infarction for these four respective groups were: 171.3 +/- 9.1, 173 +/- 5.7, 179.3 +/- 5.2, and 206.2 +/- 8.4 mm3 (mean +/- standard error of the mean, n = 6 per group). These results demonstrated that optimal duration of mild hypothermia was at least 3 hours (P < 0.001) when applied within the first 30 minutes after the onset of ischemia (P < 0.001).     

莺-琼盆地的独特埋藏史

通过沉积速率线性外推剥蚀厚度恢复、脱压实和异常高压以及古水深校正的单井埋藏史和连井埋藏剖面及构造沉降分析,发现莺-琼盆地是个多旋回沉积盆地,其沉积物埋藏过程可分为早期缓慢浅埋和晚期快速深埋两大阶段.这种独特的埋藏历史不仅是储层孔隙增生与保存的主要控制因素之一,而且极大地影响了烃源岩于酪根热解反应路径、烃类的运移和聚集,异常高压的发育以及所发生的复杂的水(气)—岩相互作用.涸11-4油田位于南海北部湾盆地涸西南凹陷,距广西北海市103km,离涸10-3油田17km.油田于1993年9月19日投产,目前开发形势较好,产量、压力稳定.在开发实践中我们体会到,要提高油田开发水平,搞好油藏监测是非常重要的.1钻井和完井过程中的油藏监测     

面向对象方法在7号信令软件设计中的应用

随着交换技术的飞速发展，程控交换软件的规模越来越大，改动也越来越频繁，如何使代码对数据的改动具有相对的稳定性成为程控软件设计的一个首要问题。本文以ＣＣＳ７（７号公共信道信令）为例，从对象模型、动态模型、功能模型３个方面阐述了ＯＯ（面向对象）方法在ＣＣＳ７软件设计中的应用。这一方法，也可应用于程控软件的设计。     

S－148芳醇不饱和聚酯树脂耐腐蚀机理研究

合成了Ｓ－１４８芳醇不饱和聚酯树脂，研究了Ｓ－１４８树脂浇铸体和玻璃钢于不同温度下在不同介质中的耐酸、碱、盐腐蚀性能，并探讨了其耐腐蚀机理。结果表明，Ｓ－１４８树脂具有优异的耐腐蚀性能，可用作耐腐蚀制品的基体树脂。     

EC与~（99m）Tc－GH之间的配体交换反应动力学研究

实验表明，ＥＣ浓度与配体交换反应速度常数无关，体系的ｐＨ值对速度常数和９９ｍＴｃ－ＥＣ的标记率影响较大。测定并计算了不同ｐＨ值的交换反应速度常数。结果表明，为保证用配体交换法制备９９ｍｃ－ＥＣ时９９ｍｃ－ＥＣ的标记率大于９０％，体系的ｐＨ值必须≥８。     

钢铁表面锌系磷化膜的研究

本文采用ＳＥＭ和ＴＥＭ等测试手段，研究了四功能处理液不同条件下在钢铁表面上形成锌系磷化膜的形貌，晶体结构；采用ＥＤＳ研究了磷化膜的化学成发，通过实验确定了Ｚｎ／Ｐ值在２．１２～３．２０时，磷化膜具有良好的耐蚀性。     

心电图数据压缩技术

本文介绍了在计算机上实现的二种心电图数据压缩方法，并详述了每种压缩法对心电图压缩技术的压缩比、失真度的影响。     

High-performance InP/InGaAs heterojunction bipolar transistors with highly carbon-doped base grown by chemical beam epitaxy

InP/In/sub 0.53/Ga/sub 0.47/As heterojunction bipolar transistors (HBTs) using a highly carbon-doped base are reported. High carbon doping has been achieved by chemical beam epitaxy (CBE). The resulting hole concentration in the carbon-doped base is as high as 7*10/sup 19//cm/sup 3/. To the authors' knowledge, this is the highest doping level reported using carbon. HBTs with a 20 AA spacer layer exhibited nearly ideal I-V characteristics with collector and base current ideality factor of 1.018 and 1.037, respectively. Current gain and breakdown voltage BV/sub CEO/ were 7 and 6 V, respectively.<>