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41.
Rakan Matsui Masaaki Hasegawa Masami Ishida Toshiya Ebata Noriyuki Namiki Kenji Sugibayashi 《Drug development and industrial pharmacy》2013,39(8):729-738
ABSTRACTIn vitro permeation of lidocaine (lidocaine base, LID) through excised rat skin was investigated using several LID-suspended oily formulations. The first skin permeation of LID from an LID-suspended oily solution such as liquid paraffin (LP), isopropyl myristate (IPM), polyoxyethylene (2) oleylether (BO-2), and diethyl sebacate (DES) was evaluated and compared with that from polyethylene glycol 400 (PEG400) solution, a hydrophilic base. The obtained permeation rate of LID, Japp, from PEG400, LP, IPM, BO-2, and DES was in the order of DES>BO-2 = IPM>LP>PEG400, and increased with LID solubility in the oily solvents, although LID crystals were dispersed in all solvents. Subsequently, oily formulations that consisted of different ratios of the first oily solvent (IPM, BO-2, or DES) (each 0–20%), the second oily solvent (LP) and an oily mixture of microcrystalline wax/white petrolatum/paraffin (1/5/4) were evaluated. BO-2 groups at a concentration of 5% and 10% had the highest Japp among the oily formulations, although a higher BO-2 resulted in lower skin permeation. In addition, pretreatment with BO-2 increased the skin permeation of LID. These results suggest that the penetration enhancing effect by the system may be related to the skin penetration of BO-2 itself. Finally, mathematical analysis was done to evaluate the effect of BO-2, and it was shown that BO-2 improved the LID solubility in stratum corneum lipids to efficiently enhance the LID permeation through skin. 相似文献
42.
l‐Citrulline Supplementation‐Increased Skeletal Muscle PGC‐1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight
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Scope
l ‐citrulline has recently been reported as a more effective supplement for promoting intracellular nitric oxide (NO) production compared to l ‐arginine. Here, the effect of l ‐citrulline on skeletal muscle and its influence on exercise performance were investigated. The underlying mechanism of its effect, specifically on the expression of skeletal muscle peroxisome proliferator‐activated receptor‐gamma coactivator‐1α (PGC‐1α), was also elucidated.Methods and results
Six‐week‐old ICR mice were orally supplemented with l ‐citrulline (250 mg kg?1) daily, and their performance in weight‐loaded swimming exercise every other day for 15 days, was evaluated. In addition, mice muscles were weighed and evaluated for the expression of PGC‐1α and PGC‐1α‐regulated genes. Mice orally supplemented with l ‐citrulline had significantly higher gastrocnemius and biceps femoris muscle mass. Although not statistically significant, l ‐citrulline prolonged the swimming time to exhaustion. PGC‐1α upregulation was associated with vascular endothelial growth factor α (VEGFα) and insulin‐like growth factor 1 (IGF‐1) upregulation. VEGFα and IGF‐1 are important for angiogenesis and muscle growth, respectively, and are regulated by PGC‐1α. Treatment with NG‐nitro‐l ‐arginine methyl ester hydrochloride (l ‐NAME), a nitric oxide synthesis inhibitor, suppressed the l ‐citrulline‐induced PGC‐1α upregulation in vitro.Conclusion
Supplementation with l ‐citrulline upregulates skeletal muscle PGC‐1α levels resulting in higher skeletal muscle weight that improves time to exhaustion during exercise.43.
Design of a photocatalyst for bromate decomposition: surface modification of TiO2 by pseudo-boehmite
The rate of BrO3- reduction by a commercial TiO2 photocatalyst under UV illumination in an aqueous solution was increased by lowering the pH from 7 to 5. The effect is attributable to an enhancement of the electrical interaction between BrO3- and the positively charged surfaces of the TiO2 photocatalyst. The surface charge can be controlled by a surface modification of the TiO2 photocatalyst without controlling the pH of the water. In fact, the isoelectric point of surface-modified TiO2 was higher than that of the unloaded TiO2 photocatalyst, resulting in an increase in the rate of the photocatalytic reduction of BrO3- at a neutral pH. This increase is explained by an increase in the amount of adsorbed BrO3- on the photocatalyst surface. 相似文献
44.
Katsuya Akiyama Haeyang PakYoji Takubo Toshiya TadaYasuaki Ueki Ryo YoshiieIchiro Naruse 《Fuel Processing Technology》2011,92(7):1355-1361
Ash with a low melting point causes slagging and fouling problems in pulverized coal combustion boilers. Ash deposition on heat exchanger tubes reduces the overall heat transfer coefficient due to its low thermal conductivity. The purpose of this study is to evaluate the ash deposition for Upgraded Brown Coal (UBC) and bituminous coal in a 145 MW practical coal combustion boiler. The UBC stands for Upgraded Brown Coal. The melting temperature of UBC ash is relatively lower than that of bituminous coal ashes. Combustion tests were conducted on blended coal consisting 20 wt.% of UBC and 80 wt.% of bituminous coal. Before actual ash deposition tests, the molten slag fractions in those coal ashes were estimated by means of chemical equilibrium calculations. The calculation results showed the molten slag fraction for UBC ash reached approximately 90% at 1523 K. However, that for blended coal ash decreased to 50%. These calculation results mean that blending UBC with bituminous coal played a role in decreasing the molten slag fraction. This phenomenon occurred because the coal blending led to the formation of alumino-silicates compounds as a solid phase. Next, ash deposition tests were conducted using a practical pulverized coal combustion boiler. A water-cooled stainless-steel tube was inserted in locations at both 1523 K and 1273 K in the boiler to measure the amount of ash deposits. The results showed that the mass of ash deposition for blended coal did not greatly increase, compared with that for bituminous coal alone. Therefore, appropriately blending UBC with bituminous coal enabled the use of UBC without any ash deposition problems in practical boilers. 相似文献
45.
Shin‐Ichi Tanaka Tsukasa Miyagi Toshiya Ohtaka Mikimasa Iwata Tadashi Amakawa Yutaka Goda 《Electrical Engineering in Japan》2011,174(4):9-18
This paper describes the phenomenon of internal pressure‐rise due to arcs ignited between metal rod electrodes in air. First, the internal pressure‐rises in a closed chamber due to arcs were measured at currents within the range of 1 to 12.5 kA. The rod electrodes were made of copper, iron, and aluminum, and were 20 mm in diameter. The measurements showed that the maximum pressure‐rise distinctly differed with each electrode material at the same total arc energy, namely, the maximum pressure‐rise was the highest in the case of the aluminum electrode and was the lowest in the case of the iron electrode. Next, to quantitatively verify this difference, the internal pressure‐rise was estimated, taking into account the energy balance in the closed chamber on each electrode material. It was found that the estimated pressure‐rise approximately agreed with the above experimental results by taking into consideration oxidation reactions of the electrodes, melting and vaporization of the electrodes, and radiation loss of the arcs under certain realistic assumptions. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 174(4): 9–18, 2011; Published online in Wiley Online Library ( wileyonlinelibrary.com ). DOI 10.1002/eej.21071 相似文献
46.
Hata K Kubota M Shimizu M Moriwaki H Kuno T Tanaka T Hara A Hirose Y 《International journal of molecular sciences》2011,12(11):8133-8145
The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC). The aim of this study was to develop a novel animal model in order to clarify the pathobiology of CRC development in obese and diabetic patients. We developed an animal model of obesity and colorectal cancer by breeding the C57BL/KsJ-db/db (db/db) mouse, an animal model of obesity and type II diabetes, and the C57BL/6J-Apc(Min/+) (Min/+) mouse, a model of familial adenomatous polyposis. At 15 weeks of age, the N9 backcross generation of C57BL/KsJ-db/db-Apc(Min/+) (db/db-Min/+) mice developed an increased incidence and multiplicity of adenomas in the intestinal tract when compared to the db/m-Min/+ and m/m-Min/+ mice. Blood biochemical profile showed significant increases in insulin (8.3-fold to 11.7-fold), cholesterol (1.2-fold to 1.7-fold), and triglyceride (1.2-fold to 1.3-fold) in the db/db-Min/+ mice, when compared to those of the db/m-Min/+ and m/m-Min/+ mice. Increases (1.4-fold to 2.6-fold) in RNA levels of insulin-like growth factor (IGF)-1, IRF-1R, and IGF-2 were also observed in the db/db- Min/+ mice. These results suggested that the IGFs, as well as hyperlipidemia and hyperinsulinemia, promoted adenoma formation in the db/db-Min/+ mice. Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients. 相似文献
47.
Large Magnetovolume Effect Induced by Embedding Ferromagnetic Clusters into Antiferromagnetic Matrix of Cobaltite Perovskite
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Ping Miao Xiaohuan Lin Akihiro Koda Sanghyun Lee Yoshihisa Ishikawa Shuki Torii Masao Yonemura Takashi Mochiku Hajime Sagayama Shinichi Itoh Kazutaka Ikeda Toshiya Otomo Yinxia Wang Ryosuke Kadono Takashi Kamiyama 《Advanced materials (Deerfield Beach, Fla.)》2017,29(27)
Materials that show negative thermal expansion (NTE) have significant industrial merit because they can be used to fabricate composites whose dimensions remain invariant upon heating. In some materials, NTE is concomitant with the spontaneous magnetization due to the magnetovolume effect (MVE). Here the authors report a new class of MVE material; namely, a layered perovskite PrBaCo2O5.5+x (0 ≤ x ≤ 0.41), in which strong NTE [β ≈ ?3.6 × 10?5 K?1 (90–110 K) at x = 0.24] is triggered by embedding ferromagnetic (F) clusters into the antiferromagnetic (AF) matrix. The strongest MVE is found near the boundary between F and AF phases in the phase diagram, indicating the essential role of competition between the F‐clusters and the AF‐matrix. Furthermore, the MVE is not limited to the PrBaCo2O5.5+x but is also observed in the NdBaCo2O5.5+x . The present study provides a new approach to obtaining MVE and offers a path to the design of NTE materials. 相似文献
48.
Yong‐Woo Shin Hisayuki Nakatani Toshiya Uozumi Boping Liu Tsuneji Sano Koh‐hei Nitta Minoru Terano 《Polymer International》2003,52(1):29-34
During propylene polymerization with the Cr(acetylacetonate)3/MgCl2–Et2AlCl–ethylbenzoate catalyst system which shows high isospecificity for propylene polymerization, it was found that the chain transfer and termination reactions can be neglected. Based on this result, some stepwise polymerizations of propylene and ethylene were carried out with the same catalyst system varying polymerization conditions. The resulting copolymers were separated by temperature rising elution fractionation (TREF) and afforded two fractions which were eluted at different temperatures. From the 13C NMR, DSC and GPC analyses of each fraction, it was considered that the corresponding block copolymer existed in the fraction eluted at higher temperature. © 2003 Society of Chemical Industry 相似文献
49.
50.
M Urashima G Teoh A Ogata D Chauhan SP Treon Y Sugimoto C Kaihara M Matsuzaki Y Hoshi JA DeCaprio KC Anderson 《Canadian Metallurgical Quarterly》1997,3(11):2173-2179
Loss of p16(INK4A) (p16) expression is frequently associated with the development of epithelial and lymphoid malignancies. However, the frequency and significance of p16 abnormalities in multiple myeloma (MM) and the more aggressive phase of plasma cell leukemia (PCL) have not been well defined. Accordingly, the goal of this study was to define the expression and function of p16 in fresh samples of MM and PCL. We found that p16 protein was highly expressed in primary MM cells, although it was undetectable in fresh samples of PCL. Additionally, p16 protein was also absent in four of four MM-derived cell lines. To determine the mechanism for p16 underexpression in PCL and MM-derived cell lines, we performed PCR analysis to evaluate both gene deletion and the presence of methylation. Interestingly, the p16 gene was present and methylated in all patient PCL cells and MM cell lines, whereas it was unmethylated in patient MM cells and normal B cells. Furthermore, treatment with the demethylating agent 5-deoxyazacytidine or p16 retrofection restored p16 protein expression and induced G1 growth arrest in patient PCL cells and MM cell lines. These results suggest that inactivation of the p16 gene by methylation may be associated with decreased growth control and the development of PCL in a subset of patients with MM. 相似文献