99Tcm-YDPC在荷瘤裸鼠体内的分布与放射免疫显像

Ｓｃｈｗａｒｔｚ直接还原法制备＾９９Ｔｃ＾ｍ－ＹＤＰＣ,分别采用Ｌｉｎｄｍｏ法与Ｓｃａｔｃｈａｒｄ示测定标记抗体的体外免疫活性分数及亲和常数,经尾静脉注射１４．４ＭＢｑ＾９９５ｃ＾ｍ－ＹＤＰＣ于荷瘤裸鼠,２２ｈ后进行γ照相及体内放射性分布测定,并用荷结肠癌裸鼠进行对照。研究结果显示：＾９９Ｔｃ＾ｍ对ＹＤＰＣ的标记率为１％－６５Ａ％,＾９９Ｔｃ＾ｍ－ＹＤＰＣ的免疫活性分数为５８．１％,对人前列腺癌细     

一类跟踪最优控制问题的次优解法及其应用

讨论了一类跟踪最优控制问题的次优解法。采用亏数为2的分段三次样条描述方案使泛函极小问题转化为多变量参数寻优问题。使用Newton-Raphson迭代方法并讨论了减少计算量的技术以及状态初值的修正方法。给出了一个来自实际的应用例,表明这种次优解法具有工程实用价值。     

2D Ruddlesden–Popper Polycrystalline PerovskitePyro-Phototronic Photodetectors

Two-dimensional (2D) Ruddlesden–Popper (RP) layered halide perovskite has attracted wide attentions due to its unique structure and excellent optoelectronic properties. With inserting organic cations, inorganic octahedrons are forced to extend in a certain direction, resulting in an asymmetric 2D perovskite crystal structure and causing spontaneous polarization. The pyroelectric effect resulted from spontaneous polarization exhibits a broad prospect in the application of optoelectronic devices. Herein, 2D RP polycrystalline perovskite (BA)₂(MA)₃Pb₄I₁₃ film with excellent crystal orientation is fabricated by hot-casting deposition, and a class of 2D hybrid perovskite photodetectors (PDs) with pyro-phototronic effect is proposed, achieving temperature and light detection with greatly improved performance by coupling multiple energies. Because of the pyro-phototronic effect, the current is ≈35 times to that of the photovoltaic effect current under 0 V bias. The responsivity and detectivity are 12.7 mA W⁻¹ and 1.73 × 10¹¹ Jones, and the on/off ratio can reach 3.97 × 10³. Furthermore, the influences of bias voltage, light power density, and frequency on the pyro-phototronic effect of 2D RP polycrystalline perovskite PDs are explored. The coupling of spontaneous polarization and light facilitates photo-induced carrier dissociation and tunes the carrier transport process, making 2D RP perovskites a competitive candidate for next-generation photonic devices.     

Code-based Sequential Aggregate Signature Scheme

This paper proposes the first code-based quantum immune sequential aggregate signature (SAS) scheme and proves the security of the proposed scheme in the random oracle model. Aggregate signature (AS) schemes and sequential aggregate signature schemes allow a group of potential signers to sign different messages respectively, and all the signatures of those users on those messages can be aggregated into a single signature such that the size of the aggregate signature is much smaller than the total size of all individual signatures. Because of the aggregation of many signatures into a single short signature, AS and SAS schemes can reduce bandwidth and save storage; moreover, when a SAS is verified, not only the valid but also the order in which each signer signed can be verified. AS and SAS schemes can be applied to traffic control, banking transaction and military applications. Most of the existing AS and SAS schemes are based either on pairing or Rivest–Shamir–Adleman (RSA), and hence, can be broken by Shor’s quantum algorithm for Integer Factoring Problem (IFP) and Discrete Logarithm Problem (DLP). There are no quantum algorithms to solve syndrome decoding problems. Hence, code-based cryptography is seen as one of the promising candidates for post-quantum cryptography. This paper shows how to construct quantum immune sequential aggregate signatures based on coding theory. Specifically, we construct our scheme with the first code based signature scheme proposed by Courtois, Finiasz and Sendrier (CFS). Compared to the CFS signature scheme without aggregation, the proposed sequential aggregate signature scheme can save about 90% storage when the number of signers is asymptotically large.     

Hydrogen Terminated Germanene for a Robust Self‐Powered Flexible Photoelectrochemical Photodetector

As a rising star in the family of graphene analogues, germanene shows great potential for electronic and optical device applications due to its unique structure and electronic properties. It is revealed that the hydrogen terminated germanene not only maintains a high carrier mobility similar to that of germanene, but also exhibits strong light–matter interaction with a direct band gap, exhibiting great potential for photoelectronics. In this work, few‐layer germanane (GeH) nanosheets with controllable thickness are successfully synthesized by a solution‐based exfoliation–centrifugation route. Instead of complicated microfabrication techniques, a robust photoelectrochemical (PEC)‐type photodetector, which can be extended to flexible device, is developed by simply using the GeH nanosheet film as an active electrode. The device exhibits an outstanding photocurrent density of 2.9 µA cm^?2 with zero bias potential, excellent responsivity at around 22 µA W^?1 under illumination with intensity ranging from 60 to 140 mW cm^?2, as well as short response time (with rise and decay times, t_r = 0.24 s and t_d = 0.74 s). This efficient strategy for a constructing GeH‐based PEC‐type photodetector suggests a path to promising high‐performance, self‐powered, flexible photodetectors, and it also paves the way to a practical application of germanene.     

Synthesis, Crystal Structure and Electrochemical Properties of 2D Network Complex {[K(N18C6)]2(CH3CN)}[Ni(mnt)2] with N18C6 = 2,3-Naphtho-18-Crown-6

A novel 2D network complex [K(N18C6)]₂(CH₃CN) [Ni(mnt)₂] (1) (where N18C6 = 2,3-naphtho-18-crown-6 and mnt = maleonitriledithiolate) has been synthesized and characterized by elemental analysis, FT-IR spectrum, UV-visible spectrum and single crystal X-ray diffraction. The complex molecules are linked into 1D chains by the bridging CH₃CN molecules through weak K-N interactions and the result chains are assembled into a novel 2D network through the inter-chain π–π stacking interactions occurred between adjacent naphthylene moieties of N18C6. The cyclic voltammogram of the title complex displays a reversible process corresponding to the [Ni(mnt)₂]^?/[Ni(mnt)₂]^2? reaction.     

结构实验系统软件的设计与实现

讨论了结构实验系统软件的设计与实现.整个系统采用两层结构,前端设置一台工控一体工作站,负责处理与底层控制装置的通讯.后台机接收到工控一体工作站的数据包后,及时对数据进行处理.     

半导体激光贴肤照射手背皮下静脉血液疗法研究

提出一种将半导体激光器(LD)贴近皮肤照射皮下静脉进行激光血液辐照治疗的新方法。该方法以手背皮下静脉作为激光照射点,采用650nm波长激光。给出了新方法所依据的实验基础,论述了新方法的可行性,说明了与新方法相适应的激光照射装置的设计方案及其照射方式,目的是为改进激光血液照射疗法探索新途径。     

Layered MoS2 Hollow Spheres for Highly‐Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors

Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand‐new MoS₂ nanostructure is designed and fabricated, i.e., layered MoS₂ hollow spheres (LMHSs) with strong absorption in near‐infrared region (NIR) and high photothermal conversion efficiency via a simple and fast chemical aerosol flow method. Owing to curving layered hollow spherical structure, the as‐prepared LMHSs exhibit unique electronic properties comparing with MoS₂ nanosheets. In vitro and in vivo studies demonstrate their high photothermal ablation of cell and tumor elimination rate by single NIR light irradiation. Systematic acute toxicity study indicates that these LMHSs have negligible toxic effects to normal tissues and blood. Remarkably, minimally invasive interventional techniques are introduced to improve tumor targeting of PTT agents for the first time. To explore PTT efficiency on orthotopic transplantation tumors, New Zealand white rabbits with VX₂ tumor in liver are used as animal models. The effective elimination of tumors is successfully realized by PTT under the guidance of digital subtraction angiography, computed tomography, and thermal imaging, which provides a new way for tumor‐targeting delivery and cancer theranostic application.