软土地区建筑基坑无撑开挖探讨

以上海地区常见的住宅小区车库基坑开挖实例分析无撑开挖的可行性.强调要在对基地土质和周边环境充分认知的情况下,辅以围护加强或边坡强化,按"时空效应"挖土和严密的信息化监挖是实现无撑开挖的前提条件.     

冲击压实技术在旧有沥青结构道路改造中的应用

结合某省道旧有沥青结构道路改造采用的冲击压实技术,结合一系列实测结果,介绍了冲击压路机冲击压实机理,探讨并建议了在不同道路病害成因的情况下,冲击压路机型号选择、冲压效果的检测标准确定、冲压效果的评定以及相关注意事项,具有一定的参考价值。     

耐火钢与普通结构钢高温强度的比较试验

对两种耐火钢(FR)与普通结构钢在常温到高温700℃之间的力学性能比较试验研究结果显示,耐火钢比普通结构钢具有更好的高温力学性能,耐火钢在约650℃时的屈服强度为常温下强度的50%,而普通结构钢在550℃时的屈服强度就已降到常温下强度的50%。同时耐火钢的高温(600℃)蠕变也比普通结构钢的小。研究结果表明在建筑设计中用耐火钢替代需要采取防火措施的普通结构钢更经济安全。     

BIM在铁路四电工程的适应性分析

目前的BIM应用与各种新兴信息技术相结合,在多领域均有其身影,而铁路四电工程因其多专业交叉、施工难、跨自然区域大等特点,迫切地需要BIM来提高设计、施工的效率。为使BIM在铁路四电工程中更好地应用,分析了应用中出现的问题,并提出解决对策,为BIM在铁路四电工程中的实际应用提供一定参考。     

基于IFC认证的BIM建模软件选择方案研究

近年来,国内外对BIM技术在建筑行业中的应用越来越重视,BIM已成为未来建筑行业技术的发展趋势。作为BIM实施的第一步,BIM模型的创建对BIM的成功应用和推广具有重要的意义。IFC数据标准作为国际通用的BIM基础数据格式,可以使以IFC标准格式形成的BIM模型,在多种AEC工程软件中进行信息传递及交换。当前,不同的软件对IFC格式的支持范围及支持程度各不相同。本文针对BuildingSMART的Coordination View Certification 2.0项目中对当前主流BIM软件的IFC2X3支持情况的统计,进行了整理与分析,得出面向IFC的BIM建模软件选择方案,为不同特点的项目BIM应用提供软件参考,从而促进IFC标准的发展以及BIM技术的普及。     

Endogenous Modulation of Extracellular Matrix Collagen during Scar Formation after Myocardial Infarction

Myocardial infarction is remains the leading cause of death in developed countries. Recent data show that the composition of the extracellular matrix might differ despite similar heart function and infarction sizes. Because collagen is the main component of the extracellular matrix, we hypothesized that changes in inflammatory cell recruitment influence the synthesis of different collagen subtypes in myofibroblasts, thus changing the composition of the scar. We found that neutrophils sustain the proliferation of fibroblasts, remodeling, differentiation, migration and inflammation, predominantly by IL-1 and PPARγ pathways (n = 3). They also significantly inhibit the mRNA expression of fibrillar collagen, maintaining a reduced stiffness in isolated myofibroblasts (n = 4–5). Reducing the neutrophil infiltration in CCR1^−/− resulted in increased mRNA expression of collagen 11, moderate expression of collagen 19 and low expression of collagen 13 and 26 in the scar 4 weeks post infarction compared with other groups (n = 3). Mononuclear cells increased the synthesis of all collagen subtypes and upregulated the NF-kB, angiotensin II and PPARδ pathways (n = 3). They increased the synthesis of collagen subtypes 1, 3, 5, 16 and 23 but reduced the expression of collagens 5 and 16 (n = 3). CCR2^−/− scar tissue showed higher levels of collagen 13 (n = 3), in association with a significant reduction in stiffness (n = 4–5). Upregulation of the inflammation-related genes in myofibroblasts mostly modulated the fibrillar collagen subtypes, with less effect on the FACIT, network-forming and globular subtypes (n = 3). The upregulation of proliferation and differentiation genes in myofibroblasts seemed to be associated only with the fibrillar collagen subtype, whereas angiogenesis-related genes are associated with fibrillar, network-forming and multiplexin subtypes. In conclusion, although we intend for our findings to deepen the understanding of the mechanism of healing after myocardial infarction and scar formation, the process of collagen synthesis is highly complex, and further intensive investigation is needed to put together all the missing puzzle pieces in this still incipient knowledge process.     

Development of a Multi-Criteria Decision-Making Approach for Evaluating the Comprehensive Application of Herbaceous Peony at Low Latitudes

The growing region of herbaceous peony (Paeonia lactiflora) has been severely constrained due to the intensification of global warming and extreme weather events, especially at low latitudes. Assessing and selecting stress-tolerant and high-quality peony germplasm is essential for maintaining the normal growth and application of peonies under adverse conditions. This study proposed a modified multi-criteria decision-making (MCDM) model for assessing peonies adapted to low-latitude climates based on our previous study. This model is low-cost, timesaving and suitable for screening the adapted peony germplasm under hot and humid climates. The evaluation was conducted through the analytic hierarchy process (AHP), three major criteria, including adaptability-related, ornamental feature-related and growth habits-related criteria, and eighteen sub-criteria were proposed and constructed in this study. The model was validated on fifteen herbaceous peonies cultivars from different latitudes. The results showed that ‘Meiju’, ‘Hang Baishao’, ‘Hongpan Tuojin’ and ‘Bo Baishao’ were assessed as Level I, which have strong growth adaptability and high ornamental values, and were recommended for promotion and application at low latitudes. The reliability and stability of the MCDM model were further confirmed by measuring the chlorophyll fluorescence of the selected adaptive cultivars ‘Meiju’ and ‘Hang Baishao’ and one maladaptive cultivar ‘Zhuguang’. This study could provide a reference for the introduction, breeding and application of perennials under everchanging unfavorable climatic conditions.     

Fascaplysin Induces Apoptosis and Ferroptosis,and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression

Fascaplysin is a natural product isolated from sponges with a wide range of anticancer activities. However, the mechanism of fascaplysin against NSCLC has not been clearly studied. In this study, fascaplysin was found to inhibit migration by regulating the wnt/β-catenin signaling pathway and reversing the epithelial–mesenchymal transition phenotype. Further research showed that the anti-NSCLC effect of fascaplysin was mainly through the induction of ferroptosis and apoptosis. Fascaplysin-induced ferroptosis in lung cancer cells, evidenced by increased levels of ROS and Fe²⁺ and downregulation of ferroptosis-associated protein and endoplasmic reticulum stress, was involved in fascaplysin-induced ferroptosis. In addition, ROS was found to mediate fascaplysin-induced apoptosis. Fascaplysin significantly upregulated the expression of PD-L1 in lung cancer cells, and enhanced anti-PD-1 antitumor efficacy in a syngeneic mouse model. Therefore, these results suggest that fascaplysin exerts anticancer effects by inducing apoptosis and ferroptosis in vitro, and improving the sensitivity of anti-PD-1 immunotherapy in vivo. Fascaplysin is a promising compound for the treatment of NSCLC.     

The Role of Circular RNAs in the Physiology and Pathology of the Mammalian Ovary

Circular RNAs (circRNAs) are an abundant class of endogenous non-coding RNAs (ncRNAs) generated from exonic, intronic, or untranslated regions of protein-coding genes or intergenic regions. The diverse, stable, and specific expression patterns of circRNAs and their possible functions through cis/trans regulation and protein-coding mechanisms make circRNA a research hotspot in various biological and pathological processes. It also shows practical value as biomarkers, diagnostic indicators, and therapeutic targets. This review summarized the characteristics, classification, biogenesis and elimination, detection and confirmation, and functions of circRNAs. We focused on research advances circRNAs in the mammalian ovary under conditions including ovarian cancer, polycystic ovarian syndrome (PCOS), and maternal aging, as well as during reproductive status, including ovarian follicle development and atresia. The roles of circRNAs in high reproductive traits in domestic animals were also summarized. Finally, we outlined some obstructive factors and prospects to work with circRNA, aiming to provide insights into the functional research interests of circRNAs in the reproduction and gynecology areas.