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61.
Predicting catastrophic temperature changes based on past events via a CNN-LSTM regression mechanism
Yusuf Syed Adnan Alshdadi Abdulrahman A. Alassafi Madini O. AlGhamdi Rayed Samad Abdul 《Neural computing & applications》2021,33(15):9775-9790
Neural Computing and Applications - The modelling and prediction of extreme temperature changes in enclosed compartments is a domain with applications ranging from residential fire alarms,... 相似文献
62.
Oguzhan Oguz Nicolas Candau Adrien Demongeot Mehmet Kerem Citak Fatma Nalan Cetin Grégory Stoclet Véronique Michaud Yusuf Z. Menceloglu 《Polymer Engineering and Science》2021,61(4):1028-1040
There is currently considerable interest in developing stiff, strong, tough, and heat resistant poly(lactide) (PLA) based materials with improved melt elasticity in response to the increasing demand for sustainable plastics. However, simultaneous optimization of stiffness, strength, and toughness is a challenge for any material, and commercial PLA is well-known to be inherently brittle and temperature-sensitive and to show poor melt elasticity. In this study, we report that high-shear mixing with cellulose nanocrystals (CNC) leads to significant improvements in the toughness, heat resistance, and melt elasticity of PLA while further enhancing its already outstanding room temperature stiffness and strength. This is evidenced by (i) one-fold increase in the elastic modulus (6.48 GPa), (ii) 43% increase in the tensile strength (87.1 MPa), (iii) one-fold increase in the strain at break (∼6%), (iv) two-fold increase in the impact strength (44.2 kJ/m2), (v) 113-fold increase in the storage modulus at 90°C (787.8 MPa), and (vi) 103-fold increase in the melt elasticity at 190°C and 1 rad/s (∼105 Pa) via the addition of 30 wt% CNC. It is hence possible to produce industrially viable, stiff, strong, tough, and heat resistant green materials with improved melt elasticity through high-shear mixing. 相似文献
63.
Hashem O. Alsaab Alanoud S. Al-Hibs Rami Alzhrani Khawlah K. Alrabighi Aljawharah Alqathama Akram Alwithenani Atiah H. Almalki Yusuf S. Althobaiti 《International journal of molecular sciences》2021,22(4)
Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular endothelium growth factor (VEGF) plays a leading role in angiogenesis progression. Antiangiogenic medication has gained substantial recognition and is commonly administered in many forms of human cancer, leading to a rising interest in cancer therapy. However, this treatment method can lead to a deteriorating outcome of resistance, invasion, distant metastasis, and overall survival relative to its cytotoxicity. Furthermore, there are significant obstacles in tracking the efficacy of antiangiogenic treatments by incorporating positive biomarkers into clinical settings. These shortcomings underline the essential need to identify additional angiogenic inhibitors that target numerous angiogenic factors or to develop a new method for drug delivery of current inhibitors. The great benefits of nanoparticles are their potential, based on their specific properties, to be effective mechanisms that concentrate on the biological system and control various important functions. Among various therapeutic approaches, nanotechnology has emerged as a new strategy for treating different cancer types. This article attempts to demonstrate the huge potential for targeted nanoparticles and their molecular imaging applications. Notably, several nanoparticles have been developed and engineered to demonstrate antiangiogenic features. This nanomedicine could effectively treat a number of cancers using antiangiogenic therapies as an alternative approach. We also discuss the latest antiangiogenic and nanotherapeutic strategies and highlight tumor vessels and their microenvironments. 相似文献
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65.
Mohammad Mojtaba Sadeghi Mohamed F. Salama Yusuf A. Hannun 《International journal of molecular sciences》2021,22(11)
Driver-directed therapeutics have revolutionized cancer treatment, presenting similar or better efficacy compared to traditional chemotherapy and substantially improving quality of life. Despite significant advances, targeted therapy is greatly limited by resistance acquisition, which emerges in nearly all patients receiving treatment. As a result, identifying the molecular modulators of resistance is of great interest. Recent work has implicated protein kinase C (PKC) isozymes as mediators of drug resistance in non-small cell lung cancer (NSCLC). Importantly, previous findings on PKC have implicated this family of enzymes in both tumor-promotive and tumor-suppressive biology in various tissues. Here, we review the biological role of PKC isozymes in NSCLC through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition. PKC isoforms α, ε, η, ι, ζ upregulation has been reported in lung cancer, and overexpression correlates with worse prognosis in NSCLC patients. Most importantly, PKC isozymes have been established as mediators of resistance to tyrosine kinase inhibitors in NSCLC. Unfortunately, however, PKC-directed therapeutics have yielded unsatisfactory results, likely due to a lack of specific evaluation for PKC. To achieve satisfactory results in clinical trials, predictive biomarkers of PKC activity must be established and screened for prior to patient enrollment. Furthermore, tandem inhibition of PKC and molecular drivers may be a potential therapeutic strategy to prevent the emergence of resistance in NSCLC. 相似文献
66.
David J. Banner Emre Firlar Pavel Rehak Abhijit H. Phakatkar Tara Foroozan Jodi K. Osborn Lioudmila V. Sorokina Surya Narayanan Talia Tahseen Yusuf Baggia Petr Král Tolou Shokuhfar Reza Shahbazian-Yassar 《Advanced functional materials》2021,31(18):2007736
Calcium oxalate (CaOx) is the major phase in kidney stones and the primary calcium storage medium in plants. CaOx can form crystals with different lattice types, water contents, and crystal structures. However, the conditions and mechanisms leading to nucleation of particular CaOx crystals are unclear. Here, liquid-cell transmission electron microscopy and atomistic molecular dynamics simulations are used to study in situ CaOx nucleation at different conditions. The observations reveal that rhombohedral CaOx monohydrate (COM) can nucleate via a classical pathway, while square COM can nucleate via a non-classical multiphase pathway. Citrate, a kidney stone inhibitor, increases the solubility of calcium by forming calcium-citrate complexes and blocks oxalate ions from approaching calcium. The presence of multiple hydrated ionic species draws additional water molecules into nucleating CaOx dihydrate crystals. These findings reveal that by controlling the nucleation pathways one can determine the macroscale crystal structure, hydration state, and morphology of CaOx. 相似文献
67.
68.
The research focused on nanomaterial solutions and their flow characteristics in relation to their usage. The application of such composites in biological rheological models, in particular, has received a lot of interest. The use of nanofluids in cooling tiny electronic devices like microchips and associated devices cannot be emphasized. Our goal is to explore the influence of a binary chemical reaction and Arrhenius activation energy on a hybrid nanofluid over a melting wedge in a spongy media. It is anticipated that the water-based nanoparticle contains gyrotactic microbes. By using appropriate similarity variables, the resultant dimensional nonlinear boundary-layer model is reduced and turned into a dimensionless form. A Chebyshev spectral collocation approach is useful in solving the highly nonlinear model. In terms of physical importance, the effects of important factors on developing profiles are displayed graphically and explained. Computational outcomes are obtained via MATHEMATICA. The plot of residual error is also shown to demonstrate the method's rapid convergence. According to the study's findings, by increasing the melting parameter, the rate of heat transportation at the wall decreases greatly on the average of 12.81%, but the Sherwood number becomes effective for the chemical reaction rate with a rate of about 24.81%. 相似文献
69.
Sara Sadiq Muhammad Imran Muhammad Nadeem Hassan Mazhar Iqbal Yusuf Zafar Fauzia Yusuf Hafeez 《LWT》2014
Antimicrobial behavior of lactic acid bacteria (LAB) has been explored since many years to assess their ability to produce bacteriocin, a natural preservative, to increase the shelf life of food. This study aims to characterize bacteriocin producing strains of lactic acid bacteria isolated from acidic to slightly acidic raw vegetables including tomato, bell pepper and green chili and to investigate their potential to inhibit food related bacteria. Among twenty nine LAB screened for antimicrobial activity, three exhibited antagonism against closely related bacterial isolates which was influenced by varying temperature and pH. They were identified up to strain level as Lactococcus lactis subsp. lactis TI-4, L. lactis subsp. lactis CE-2 and L. lactis subsp. lactis PI-2 based on 16S rRNA gene sequence. Their spectrum of inhibition was observed against food associated strains of Bacillus subtilis and Staphylococcus aureus. Moreover, L. lactis subsp. lactis PI-2 selected on the basis of higher antimicrobial activity was further evaluated for bacteriocin production which was detected as nisin A and nisin Z. These findings suggest the possible use of L. lactis strains of vegetable origin as protective cultures in slightly acidic as well as slightly alkaline food by the bio-preservative action of bacteriocins. 相似文献
70.
An organic-inorganic heterojunction based on a BODIPY dyes has been produced by forming dye thin film on n-Si. The electrical parameters of the structure have been investigated by current-voltage (I-V) and capacitance-voltage (C-V) measurements. The ideality factor, the barrier height and the series resistance values of the diode have been calculated as 2.43, 0.84 eV, and about 1.3 kΩ, respectively. The diode behaves as a non-ideal diode because of the series resistance and interface layer. The barrier height value obtained from I-V measurement has been compared with one from C-V measurement. Moreover, it has been seen that the diode is highly sensitive to the light and the reverse bias current increases about 1 × 104 times at −1 V under 100 mW/cm2 and AM1.5 illumination condition. The short photocurrent density (Jsc) and the open circuit voltage (Voc), the fill factor (FF) and power conversion efficiency (η) have been determined as 3.78 mA/cm2, 327 mV, 0.28 and 0.48 %, respectively. 相似文献