Experimental investigation on similarity between velocity and density profiles in density-stratified countercurrent flow in reactor horizontal leg

A density-stratified countercurrent flow was investigated to obtain data necessary to develop a physical model on a thermally stratified flow in a horizontal leg of a pressurized water reactor (PWR). The experiments were conducted at atmospheric pressure and temperature using fresh water and NaCl solution with a non-dimensional density ratio of up to 1.2. The emphasis was placed on measurements of velocity and concentration profiles near the interface between the two fluid layers. Measured mean velocity and concentration profiles were fitted consistently using the Monin–Obukhov similarity theory, which are well-known outcomes for stratified turbulent shear flow. The interfacial friction and entrainment coefficients obtained from the fitted profiles agreed well with existing results in literature, confirming the applicability of the Monin–Obukhov theory. Furthermore, a new empirical correlation was proposed for the prediction of a mixing layer thickness.     

Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis

The aim of this study was to determine whether chemo-endocrine therapy after the resection of liver metastasis from colorectal cancer would prevent recurrence in the remnant liver and prolong survival. Eleven colorectal cancer patients underwent hepatic resection for liver metastasis. Subsequently, they were administered Proglumide gastrin antagonist 1,200 mg/day + 5'-DFUR 800 mg/day for 2 years. In seven of them, MMC 6-10 mg and ADM 20 mg were infused intra-arterially every two weeks alternately for one year. In four of them, 5-FU 250 mg/day was infused for seven days continuously intra-arterially every two weeks for one year. Recurrence in the remnant liver occurred in four of 11 patients. All of these patients underwent repeated hepatectomy. The mean disease-free survival in the remnant liver was 37 months and the five-year survival rate was 91%. These results indicate that intra-arterial chemotherapy with gastrin receptor antagonist might be effective for adjuvant therapy in patients with resectable liver metastasis from colorectal cancer.     

Effects of dietary vegetable oils on behavior and drug responses in mice

Previously, we noted significant differences in the behavioral patterns of mice fed safflower oil with a very low alpha-linolenate/linoleate ratio and perilla oil with a high alpha-linolenate/linoleate ratio from mothers to offsprings. In this report, we compared the behavior and drug responses in mice fed diets containing six different vegetable oils-corn, rapeseed, soybean, safflower, perilla and a mixture of perilla and safflower oils- for a relatively short period: 8 months after weaning. Soybean oil is a component of most conventional diets and was used as a control. The alpha-linolenate/linoleate ratios of the oils appeared to affect the locomotor activities in a wheel cage: the activity decreased in the order of safflower, the mixture (1:1) and the perilla oil groups. However, the rapeseed oil group exhibited much higher locomotor activity than that expected from the alpha-linolenate/linoleate ratio. Additionally, the rapeseed oil group exhibited unusual behavior patterns, including higher ambulation and rearing activities, faster acquisition of the water maze task and slower habituation behavior as compared with the control group. Susceptibility to pentobarbital anesthesia tended to be higher in the rapeseed oil group. The differences in the alpha-linolenate/linoleate ratios of these oils alone do not account for the observed differences in the behavioral patterns among the six dietary groups. Although we cannot exclude the possibility that the observed behavioral anomaly is due to the unique fatty acid composition of rapeseed oil, we speculate that a factor(s) other than fatty acids in rapeseed oil affected nervous system functions.     

Slow crystallization process from amorphous PbTiO3

The effect of isothermal annealing of amorphous PbTiO₃ at a temperature below the crystallization temperature, T_crys, has been investigated. Time dependent dielectric constant in the annealing process has been observed. From the experimental results, both the existence of the glass transition temperature, T_g, and the steadiness of dielectric constant at room temperature have been established.     

Studies on dry spinning. I. Fundamental equations

One difficulty in analyzing the state of filament in the dry spinning process is that in the boundary conditions required to solve the equations of mass, momentum and energy which are derived on the consideration of balance with respect to infinitesimally small element are not given a priori. The equations which include these boundary conditions in themselves are derived by considering mass, momentum, and energy balances with respect to the entire cross section of filament. These additional macroscopic equations are simplified to a great extent by assuming the flat velocity profile through the cross section of filament. Besides, in the steady state, these macroscopic equations are modified to give the equations of average solvent content, spinning tension, cross-sectional area, and average temperature. When the spinning conditions are given and the physical constants are measured for a given polymer and solvent system, it becomes possible to calculate the state of filament by solving these microscopic and macroscopic equations simultaneously without resorting to actual spinning.     

Effect of temperature on the stereoselectivity of phospholipase D toward glycerol in the transphosphatidylation of phosphatidylcholine to phosphatidylglycerol

In this study, the effect of temperature on the stereoselectivity of phospholipase D (PLD) toward the two primary hydroxyl groups of glycerol in the transphosphatidylation reaction of phosphatidylcholine to phosphatidylglycerol (PtdGro) was investigated. For this purpose, PLD from bacteria (Streptomyces septatus TH-2, S. halstedii subsp. scabies K6, and Actinomadura sp.) and cabbage were tested. At the reaction temperatures employed (0–60°C), the proportions of the two PtdGro diastereomers, namely, 1,2-dioleoyl-sn-glycero-3-phospho-3′-sn-glycerol (R,R configuration) and 1,2-dioleoyl-sn-glycero-3-phosphol-1′-sn-glycerol (R,S configuration), which were produced with PLD from Streptomyces TH-2 and Actinomadura sp., changed gradually from 50% R,R and 50% R,S at 50–60°C to 70% R,R and 30% R,S at O°C. These alterations suggested that the stereoselectivity of the bacterial PLD toward the two primary hydroxyl groups of prochiral glycerol was significantly influenced by reaction temperature. PLD from Streptomyces K6 showed relatively little effect of temperature on stereoselectivity, giving 65–69% R,R in the temperature range of 60–10°C examined. The plots of In ([R,R]/[R,S]) vs. 1/T gave good linear fits for these three bacterial PLD. No temperature effect was observed for cabbage PLD, which gave an almost equimolar mixture of the R,R and R,S diastereomers in the range from 0 to 40°C. The temperature-dependent change in enantiomeric selectivity of the bacterial PLD promises potentially profitable commercial exploitation.     

Photovoltaic characteristics of TCNQ-incorporated CuPc-poly(p-phenylene) composite films

Composite films (CuPc–PPP–TCNQ) were produced by simultaneous deposition using copper phthalocyanine (CuPc) as a carrier generation material, poly(p-phenylene) (PPP) as a hole transport material, and tetracyanoquinodimethane (TCNQ) as a incorporation material. Schottky barrier photovoltaic cells, consisting of a semitransparent aluminum and the CuPc–PPP–TCNQ composite films, were fabricated. The junction properties and the photovoltaic properties on Al/CuPc–PPP–TCNQ/ITO sandwich cells were investigated. As well as a composite film of the CuPc and the PPP (CuPc–PPP), the conductivity of the CuPc–PPP–TCNQ composite film is improved as the TCNQ is simultaneously deposited in the CuPc–PPP composite film. Therefore, it is proven that the short circuit photocurrent density (J _sc) and the photovoltaic property increases significantly. The J _sc of the Al/CuPc–PPP–TCNQ/ITO cell is 2.60 A/cm², and it is found that the J _sc is about 20 times that of an Al/CuPc/ITO cell and double that of an Al/CuPc–PPP/ITO cell. Consequently, the power conversion efficiency of the Al/CuPc–PPP–TCNQ/ITO cell obtained was 3.68%.     

A Quantitative Approach for Correction of Background Counts: Determination of Left Ventricular Ejection Fraction by Radionuclide Angiocardiography

A quantitative approach for correction of background counts is described for determination of the left ventricular ejection fraction from first-pass radionuclide angiocardiography. First, the method is investigated theoretically and numerically using a mathematical model. It is demonstrated that the ejection fraction can be estimated relatively well, even in a noisy situation. Second, the method is applied to the left ventricular time-activity curves from two different regions of interest, the carefully selected and the laxly selected, and these are compared to each other. Good agreement (correlation coefficient = 0.96) for 20 patients was obtained between the ejection fractions from the carefully selected region of interest and those from the laxly selected one.     

Synchronous firing and higher-order interactions in neuron pool

The stochastic mechanism of synchronous firing in a population of neurons is studied from the point of view of information geometry. Higher-order interactions of neurons, which cannot be reduced to pairwise correlations, are proved to exist in synchronous firing. In a neuron pool where each neuron fires stochastically, the probability distribution q(r) of the activity r, which is the fraction of firing neurons in the pool, is studied. When q(r) has a widespread distribution, in particular, when q(r) has two peaks, the neurons fire synchronously at one time and are quiescent at other times. The mechanism of generating such a probability distribution is interesting because the activity r is concentrated on its mean value when each neuron fires independently, because of the law of large numbers. Even when pairwise interactions, or third-order interactions, exist, the concentration is not resolved. This shows that higher-order interactions are necessary to generate widespread activity distributions. We analyze a simple model in which neurons receive common overlapping inputs and prove that such a model can have a widespread distribution of activity, generating higher-order stochastic interactions.     

Effects of rice cleaning and cooking process on the residues of flutolanil,fenobucarb, silafluofen and buprofezin in rice

We studied the effect of cleaning and cooking on the residues of flutolanil, fenobucarb, silafluofen and buprofezin in rice. The rice had been sprayed in a paddy field in Wakayama city, with 3 kinds of pesticide application protocols: spraying once at the usual concentration of pesticides, repeated spraying (3 times) with the usual concentration of pesticides and spraying once with 3 times the usual concentration of pesticides. The residue levels of pesticide decreased during the rice cleaning process. Silafluofen, which has a higher log Pow value, remained in the hull of the rice. Fenobucarb, which has a lower log Pow value, penetrated inside the rice. The residue concentration of pesticide in polished rice was higher than that in pre-washed rice processed ready for cooking. During the cooking procedure, the reduction of pesticides in polished rice was higher than that in brown rice.