Demographic study of first-ever stroke and acute myocardial infarction in Okinawa, Japan

We performed a cross-sectional survey of stroke and acute myocardial infarction (AMI) in Okinawa, Japan with a census population of about 1.2 million. A total of 3,644 cases of first-ever stroke and 898 cases of initial acute myocardial infarction (AMI) were detected. The age-adjusted annual incidence rate for stroke was 105 per 100,000 standard population of Japan, and that of AMI was 26. The case-fatality rate of stroke within 28 days of onset was 12.8%, and that of AMI was 22.2%. Of the stroke cases, 51.4% were diagnosed as brain infarction, 38.7% as brain hemorrhage, and 9.3% as subarachnoid hemorrhage. The diagnosis of stroke subtypes were confirmed by computed tomography or magnetic resonance imaging in 98.4% of all stroke cases. In Okinawa, the incidence rate of AMI was still considerably lower than that in the Western population, and the rate of stroke was similar to that in the Western population.     

Numerical analyses of high‐beta spherical tokamaks with varied elongation

The effect of plasma elongation on the second‐stable spherical tokamak (ST) was numerically studied using the experimentally measured pressure and current profiles of ultrahigh‐beta STs. The maximum beta of ST over 50% was obtained in the TS‐3 ST/CT experiment by applying an external toroidal field to an FRC. It was found that the marginal beta for the ballooning instability increased with the plasma elongation κ of ST. The elongated STs with κ > 2 have the magnetic shear (S)–pressure gradient (α) profiles located in the second‐stable regime for the ballooning mode and the stability margin increased with κ. The close relation between the absolute minimum‐B profile and the second stability was documented. The effect of elongation on maximum beta was observed to saturate when κ exceed 3, indicating that the optimized elongation for high‐beta STs is located around 2 < κ < 3. © 2006 Wiley Periodicals, Inc. Electr Eng Jpn, 155(4): 1–6, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20132     

Melatonin inhibits naloxone-induced luteinizing hormone release in ovariectomized estrogen-primed rats

The present study aimed to examine the effect of melatonin on naloxone-induced luteinizing hormone (LH) secretion in ovariectomized estrogen-primed rats. A single intracerebroventricular (i.c.v.) injection of naloxone (mu opioid receptor blocker, 15 micrograms) or an intravenous (i.v.) injection of LH-releasing hormone (LHRH, 50 ng/kg) elicited a transient and significant increase in the serum LH concentration within 10 min. While an i.c.v. injection of 100 ng melatonin by itself did not change the basal LH release, it almost completely inhibited the naloxone-induced LH release. Melatonin (10 ng) also significantly reduced the effect of naloxone. However, an i.c.v. injection of 100 ng melatonin did not affect the LHRH-induced LH release. In separate experiments, the effect of melatonin on naloxone-induced pulsatile LH secretion was studied in estrogen-treated rats. A continuous i.v. infusion of naloxone (20 mg/kg/h) induced LH pulses in rats treated i.c.v. with saline. An i.c.v. administration of 100 ng melatonin, which by itself did not affect basal LH secretion, significantly reduced the frequency, but not the amplitude, of LH pulses induced by the naloxone infusion. These results show that melatonin has a suprapituitary site of action to inhibit naloxone-induced LH release, and suggest that melatonin has an effect in inhibiting the activity of the hypothalamic LHRH pulse generator, either directly or indirectly, in female rats.     

An instantaneous response CMOS optical receiver IC with widedynamic range and extremely high sensitivity using feed-forwardauto-bias adjustment

An instantaneous response CMOS optical-receiver IC is described with wide input dynamic range and high sensitivity. In a TCM (time compression multiplexing)-TDMA (time division multiple access) fiber-optic subscriber system, a receiver should be able to handle burst-data packets with different amplitude. This requires quick response and a wide dynamic range. Instantaneous response is achieved with a new feed-forward auto-bias adjustment technique. In addition, multistaged offset compensation provides a wide dynamic range without any external elements and adjustments. Using these design techniques, an optical receiver IC was fabricated in a standard 0.8-μm CMOS technology. The receiver has a wide dynamic range of more than 25 dB for burst-mode optical input at 29 Mb/s. It has high transimpedance gain of 150 dBΩ and high sensitivity of -42 dBm with stable operation for FET threshold voltage and power supply voltage fluctuation     

Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells

Triple-negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes. Recently, the activation of NF-κB, which is involved in the growth and survival of malignant tumors, has been demonstrated in TNBC, suggesting that NF-κB may serve as a new therapeutic target. In the present study, we examined whether dimethyl fumarate (DMF), an NF-κB inhibitor, induces apoptosis in TNBC cells and enhances the apoptosis-inducing effect of paclitaxel and adriamycin. Cell survival was analyzed by the trypan blue assay and apoptosis assay. Protein detection was examined by immunoblotting. The activation of NF-κB p65 was correlated with poor prognosis in patients with TNBC. DMF induced apoptosis in MDA-MB-231 and BT-549 cells at concentrations that were non-cytotoxic to the normal mammary cell line MCF-10A. Furthermore, DMF inhibited NF-κB nuclear translocation and Survivin, XIAP, Bcl-xL, and Bcl-2 expression in MDA-MB-231 and BT-549 cells. Moreover, DMF enhanced the apoptosis-inducing effect of paclitaxel and adriamycin in MDA-MB-231 cells. These findings suggest that DMF may be an effective therapeutic agent for the treatment of TNBC, in which NF-κB is constitutively active. DMF may also be useful as an adjuvant therapy to conventional anticancer drugs.     

On a posteriori estimates of inverse operators for linear parabolic initial-boundary value problems

We present numerically verified a posteriori estimates of the norms of inverse operators for linear parabolic differential equations. In case that the corresponding elliptic operator is not coercive, existing methods for a priori estimates of the inverse operators are not accurate and, usually, exponentially increase in time variable. We propose a new technique for obtaining the estimates of the inverse operator by using the finite dimensional approximation and error estimates. It enables us to obtain very sharp bounds compared with a priori estimates. We will give some numerical examples which confirm the actual effectiveness of our method.     

Thermal cis–trans conversion in thiophene oligomers

Thermal cis–trans conversion has been examined in oligothiophene single molecules encapsulated in the molecular vessels of cyclodextrin and Na-mordenite. At high temperatures, optical absorption intensities are enhanced in bithiophene, terthiophene and quinquethiophene, while the intensity of quarterthiophene is temperature independent. Optical absorption comes from uncompensated transition dipole moment due to the thermal torsion between cis and trans forms.     

Design of low‐power all‐optical networks under the constraint of four‐wave mixing

In this paper, we propose a static lightpath establishment method to design low‐power all‐optical networks under the constraint of four‐wave mixing (FWM). Since the FWM causes nonlinear interchannel crosstalk, it degrades the communication quality of optical signals. The FWM crosstalk effect becomes strong in a fiber as the number of passing optical signals increases. Therefore, we should reduce the number of optical signals passing through the same fiber from the perspective of the FWM. Meanwhile, in order to enhance the power efficiency of optical amplifiers, which are deployed at each optical fiber, it is preferred that multiple optical signals are transmitted in the same fiber. In order to decrease the power consumption while keeping high communication quality, the proposed method statically selects routes, wavelengths, and fibers for each traffic demand, considering the FWM crosstalk effect and the usage efficiency of the optical amplifiers. We show the performance of the proposed method through numerical experiments.     

A multigigabit DRAM technology with 6F2 open-bitlinecell, distributed overdriven sensing, and stacked-flash fuse

A multigigabit DRAM technology was developed that features a low-noise 6F² open-bitline cell with fully utilized edge arrays, distributed overdriven sensing for operation below 1 V, and a highly reliable post-packaging repair scheme using a stacked-flash fuse. This technology, which can be used to fabricate a 0,13-μm 180-mm² 1-Gb DRAM assembled in a 400-mil package, was verified using a 57.6-mm², 200-MHz array-cycle, 256-Mb test chip with 0.109-μm² cells     

Interactive multimedia communication systems for next-generationeducation using asymmetrical satellite and terrestrial networks

We propose a new concept of a hierarchical network structure for remote education. This system combines broadband satellite networks and simple terrestrial communication networks effectively to meet the demands of point-to-multipoint communications. Remote education experiments have been conducted using the proposed satellite communication networks. The results of network characteristics and degree of satisfaction are discussed. Acceptable communication quality was achieved ensuring an interactive lecture environment