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排序方式: 共有144条查询结果,搜索用时 15 毫秒
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BS Iyengar RT Dorr DS Alberts EM Hersh SE Salmon WA Remers 《Canadian Metallurgical Quarterly》1999,42(3):510-514
A set of 20 2-cyanoaziridine-1-carboxamides was synthesized from 2-cyanoaziridine and appropriate isocyanates. These compounds were active against a variety of solid and hematological tumor cells in culture, including strains resistant to doxorubicin and mitoxantrone. Their potencies in these assays correlated with the lipophilicity of substituents. The N-phenyl derivative was more potent and equally effective to imexon, a cyclized 2-cyanoaziridine-1-carboxamide of clinical interest, against cloned fresh human tumors. 相似文献
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K Aabo M Adams P Adnitt DS Alberts A Athanazziou V Barley DR Bell U Bianchi G Bolis MF Brady HS Brodovsky H Bruckner M Buyse R Canetta V Chylak CJ Cohen N Colombo PF Conte D Crowther JH Edmonson C Gennatas E Gilbey M Gore D Guthrie BY Yeap 《Canadian Metallurgical Quarterly》1998,78(11):1479-1487
The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit more or less from cisplatin- or carboplatin-based therapy. Meta-analyses were based on updated individual patient data from all available randomized controlled trials (published and unpublished), including 37 trials, 5667 patients and 4664 deaths. The results suggest that platinum-based chemotherapy is better than non-platinum therapy, show a trend in favour of platinum combinations over single-agent platinum, and suggest that cisplatin and carboplatin are equally effective. There is no good evidence that cisplatin is more or less effective than carboplatin in any particular subgroup of patients. 相似文献
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Ronca April E.; Abel Regina A.; Ronan Patrick J.; Renner Kenneth J.; Alberts Jeffrey R. 《Canadian Metallurgical Quarterly》2006,120(6):1308
Plasma catecholamines in newborn rats (0-2 hr old) were analyzed following vaginal birth, cesarean section with simulated labor contractions, or cesarean section without labor contractions. Upon delivery, pups were exposed to key elements of the rat's natural birth process, that is, umbilical cord occlusion, tactile stimulation, and cooling. Only pups exposed to actual or simulated labor showed an immediate rise in norepinephrine and epinephrine. Initial postpartum respiratory frequencies were higher in vaginal than in cesarean delivered pups and, in all groups, inversely correlated with catecholamine titers, suggesting respiratory distress or transient tachypnea at lower catecholamine levels. These findings establish a rat model for analyzing effects of labor on neonatal adaptive response during the transition from prenatal to postnatal life. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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H. L. Alberts 《Journal of Alloys and Compounds》1994,210(1-2):23-26
Magnetic effects are investigated in Cr---Ni alloys through velocity νL of sound measurements for eight alloys containing up to 3.5 at.% Ni. Magnetic anomalies are observed in the temperature dependence of νL for all the alloys studied. The results reveal a persistence of magnetic effects in Cr---Ni alloys to temperatures well above (up to 175 K above) the Néel temperatures previously observed from measurements of other physical properties. 相似文献
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Weanling Sprague Dawley rat pups (Rattus norvegicus) selected between 2 safe palatable diets in concordance with the preferences of either an adult or a juvenile conspecific model (Experiment 1). Nevertheless, weanlings chose to feed more in the vicinity of an adult than in the vicinity of a juvenile, thus fulfilling the prediction of an adaptive feeding strategy (Experiment 2). The weanlings' bias for feeding in the vicinity of an adult was eliminated by increasing the magnitude of pup stimulus to 3 pups (Experiment 3). Thus, weanlings do not possess a specialization rendering them more sensitive to adults than to pups as models for diet selection. By responding to stimulus magnitude, weanlings are more likely to feed with adult conspecifics, choose foods used by them, and derive the benefits correlated with the adults' successful feeding habits. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Nature-nurture in the classroom: entrance age, school readiness, and learning in children 总被引:1,自引:0,他引:1
The impact of entrance age on reading and mathematics achievement in 1st grade was examined. Methodological problems with past research were identified, including small size of achievement differences, failure to take background variables into account, and confusion of achievement levels with degree of learning. Using a pre-post design, growth of reading and mathematics was examined in younger 1st graders, older 1st graders, and older kindergarteners. Comparisons of background information on these groups with children who were either held out prior to or retained an extra year in kindergarten, produced minimal background differences. Results revealed that younger 1st graders made as much progress over the school year as did older 1st graders and made far more progress than older kindergarteners. Overall, findings demonstrated that, in itself, entrance age was not a good predictor of learning or academic risk. 相似文献
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LA Aaron LA Bradley GS Alarcón M Triana-Alexander RW Alexander MY Martin KR Alberts 《Canadian Metallurgical Quarterly》1997,40(3):453-460
The spectrophotometry and photofluorescence techniques were used in the studies on photochemical transformations of lactate dehydrogenase exposed to UV irradiation with a dose of 2.25 kJ/m2, in the native state and in the presence of exogenous modifiers: sodium azide, beta-carotene, histidine, D-mannitol, and tret-butanol. It was shown that UV irradiation of the mixtures of lactate dehydrogenase with sodium azide, beta-carotene, and histidine results in restoration (by 99, 65, and 63%, respectively) of the level of catalytic activity of the enzyme as compared to that observed after irradiating it in the absence of the protectors. The protective effect provided by mannitol during UV irradiation of the lactate dehydrogenase was 23%. Thus, it was shown that active oxygen species--singlet molecular oxygen and hydroxyl radical--make significant contributions to photomodification of lactate dehydrogenase. 相似文献