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91.
Alessio Alexiadis 《International journal for numerical methods in engineering》2014,100(10):713-719
In this work, a hybrid numerical approach, which combines elements of SPH and coarse‐grained molecular dynamics, is used to investigate the effect of various flow conditions to deformable and breakable shell‐structures such as capsules, vesicles or biological cells. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
92.
93.
Towards verifying contract regulated service composition 总被引:1,自引:0,他引:1
Alessio Lomuscio Hongyang Qu Monika Solanki 《Autonomous Agents and Multi-Agent Systems》2012,24(3):345-373
94.
Machine Learning - Gaussian processes (GPs) are distributions over functions, which provide a Bayesian nonparametric approach to regression and classification. In spite of their success, GPs have... 相似文献
95.
Social media provide new opportunities for supporting the dynamics of collective action (CA), allowing for the mobilisation of people into debates and involving them in new forms of collective decision making. Although current studies focus on opportunities offered by social media for collective action, there is still a need to deepen the understanding of how social media support the organisation of CA and to study the effects of individual actions performed on social media in complex organisational settings. We here explore how social media are used to manage CA by the Italian political movement Movimento Cinque Stelle, using the concept of affordances as the conceptual framing. Based on the qualitative case analyses, our study contributes to the knowledge base by identifying a typology of nine affordances supporting CA and exploring how the combined actualisations of some affordances of the typology create antecedents of the fundamental processes of CA. On the basis of the study analysis, we suggest a model to describe how social media support CA through affordances, their combinations, and the creation of antecedents and then formulate implications for research and practice. 相似文献
96.
Simone Borsci Stefano Federici Alessio Malizia Maria Laura De Filippis 《Behaviour & Information Technology》2019,38(5):519-532
A recent contribution to the ongoing debate concerning the concept of usability and its measures proposed that usability reached a dead end – i.e. a construct unable to provide stable results and to unify scientific knowledge. Extensive commentaries rejected the conclusion that researchers need to look for alternative constructs to measure the quality of interaction. Nevertheless, several practitioners involved in this international debate asked for a constructive way to move forward the usability practice. In fact, two key issues of the usability field were identified in this debate: (i) knowledge fragmentation in the scientific community, and (ii) the unstable relationship among the usability metrics. We recognise both the importance and impact of these key issues, although, in line with others, we may not agree with the conclusion that the usability is a dead end. Under the light of the international debate, this work discusses the strengths and weaknesses of usability construct and its application. Our discussion focuses on identifying alternative explanations to the issues and to suggest mitigation strategies, which may be considered the starting point to move forward the usability field. However, scientific community actions will be needed to implement these mitigation strategies and to harmonise the usability practice. 相似文献
97.
A way to perform sampling of the evanescent spectrum of an object is considered by using a photonic bandgap (PBG). The coupling between the scattered field from the object and the PBG is discussed, showing a connection of the guide modes with selected spectral components of the scattering object in free space. Some useful examples have been discussed, showing good agreement between numerical results and theoretical previsions. 相似文献
98.
Alessio Frassoldati Roberto Grana Tiziano Faravelli Eliseo Ranzi Patrick Oßwald Katharina Kohse-Höinghaus 《Combustion and Flame》2012,159(7):2295-2311
With regard to the importance of butanol as a potential replacement or additive to fossil transportation fuels, a detailed understanding of butanol combustion chemistry is desirable. Routes to different isomers of butanol from biomass are becoming available, and it is known that the structure of fuel molecules can be of crucial importance with respect to the intermediate species pool and the nature and amount of potential pollutants, including regulated air toxics. Quantitative major and intermediate species profiles for the combustion of the four butanol isomers under low-pressure premixed flame conditions, measured with two different in situ mass spectrometric instruments have recently been reported (P. Oßwald et al., Combust. Flame 158 (2011) 2–15), and this large consistent dataset has motivated us to further develop a detailed and comprehensive chemical kinetic model which was used here to complement the experimental results with numerical simulations, including reaction flow analyses. The major differences in the overall chemical pathways in these flames will be discussed, especially with respect to the formation of undesired emissions, and from agreement and differences between experiment and model, suggestions for further work will be given. 相似文献
99.
Claudio Cipolat-Gotet Alessio Cecchinato Massimo Malacarne Giovanni Bittante Andrea Summer 《Journal of dairy science》2018,101(10):8788-8804
The aim of this study was to assess the influence of the amounts of the αS1-, αS2-, β-, and κ-casein (CN) and the α-lactalbumin and β-lactoglobulin protein fractions on the efficiency of the cheese-making process independently of their genetic polymorphisms. The study was carried out on milk samples from 1,271 Brown Swiss cows from 85 herds classified into 4 categories according to management, feeding, and housing characteristics (traditional and modern systems). To assess the efficiency of the cheese-making process, we processed the milk samples according to a laboratory cheese-making procedure (1,500 mL/sample) and obtained the following measures: (1) 3 percentage cheese yields (%CYcurd, %CYsolids, %CYwater), (2) 2 daily cheese yields obtained by multiplying %CY (curd and total solids) by daily milk yields (dCYcurd, dCYsolids), (3) 4 measures of nutrient recovery in the curd (RECfat, RECprotein, RECsolids, RECenergy), and (4) 2 measures of cheese-making efficiency in terms of the ratio between the observed and theoretical %CY (Ef-%CYcurd, Ef-%CYsolids). All the aforementioned traits were analyzed by fitting 2 linear mixed models with protein fractions as fixed effects expressed as percentage in the milk (model M-%milk) and as percentage of the total casein content (model M-%cas) together with the effects of total casein content (only in model M-%cas), daily milk yield (only in model M-%milk; not for dCY traits), dairy system, herd (random effect), days in milk, parity, and vat. The efficiency of overall cheese yield (Ef-%CYcurd) was mostly positively associated with β-CN content in the milk, whereas Ef-%CYsolids was greater with higher amounts of κ-CN and αS1-CN (M-%milk) due to the strong influence of both fractions on the recovery rate of milk components in the curd (fat and total solids, protein with αS1-CN only) when expressed as percentage of milk and of total casein; only β-CN was more important for RECprotein. In contrast, we found β-lactoglobulin to be highly negatively related to all the traits related to the cheese-making process and to the daily cheese yield per cow, whereas α-lactalbumin was positively associated with the latter traits. Additional research on this topic is needed, with particular focus on the genetic and genomic aspects of the role of protein fractions in the cheese-making process and on the associations between genetic polymorphisms in milk protein and milk nutrient recovery in the curd. 相似文献
100.
Rami M Cecchi A Montero JL Innocenti A Vullo D Scozzafava A Winum JY Supuran CT 《ChemMedChem》2008,3(11):1780-1788
The synthesis and carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of two series of aromatic sulfonamides and their Cu(II) derivatives, incorporating metal-complexing moieties of the DTPA, DOTA, and TETA type are reported. The new compounds were designed in such a way as to possess high affinity for Cu(II) ions, exploiting four pendant carboxylate moieties in the DTPA derivatives, as well as the cyclen/cyclam macrocyles, and three pendant acetate moieties in the DOTA and TETA derivatives. The new derivatives showed modest inhibition of the cytosolic isoform CA I (K(I) values in the range of 66-2130 nM), were better CA II inhibitors (K(I) values in the range of 21-360 nM), and excellent inhibitors of the tumor-associated isoform CA IX (K(I) values in the range of 4.1-110 nM), with selectivity ratios for the inhibition of the tumor (CA IX) over the cytosolic (CA II) isozyme in the range of 10.74-20.88 for the best derivatives. Copper complexes were more inhibitory than the corresponding ligand sulfonamides, and showed membrane impermeability, thus, having the possibility to specifically target the transmembrane CA IX that has an extracellular active site. Incorporation of radioactive copper isotopes in this type of CA inhibitor may lead to interesting diagnostic/therapeutic applications for such compounds. 相似文献