The Employee Health Care Value Survey: round one

In a groundbreaking arrangement, a consortium of large employers--the Xerox, GTE, and Digital Equipment Corporations--launched the Employee Health Care Value Survey during fall 1993. Completed by 24,306 employees, this survey was used to develop comparable methods for assessing corporate health care benefit strategies. It also enabled fair comparisons of thirty-two health plans across the country on more than sixty criteria. Variation in performance among plans was substantial, with managed care plans--particularly prepaid group practices and individual practice associations (IPAs)--recording the most favorable rankings on disenrollment, overall satisfaction, and other measures of "bottom-line performance." Variation in enrollees' health among plans was more modest, with indemnity enrollees posing a somewhat greater illness burden to their plans than enrollees of other plan types. The employers and evaluated health plans are now using the results for multiple purposes, including quality improvement initiatives, employee-based plan performance reports, employee contribution strategies, and health promotion programs.     

Planar laser-induced-fluorescence imaging measurements of OH and hydrocarbon fuel fragments in high-pressure spray-flame combustion

Planar laser-induced fluorescence images of OH have been obtained in liquid-fueled spray flames burning heptane, ethanol, and methanol over a range of pressures from 0.1 to 1.0 MPa. In addition to the OH fluorescence, a nonresonant fluorescence interference that increased rapidly with pressure was detected. Examination of the spectrum of this interference indicates that it arises from hydrocarbon fuel-fragment species in the fuel-rich zones of the flame. The pressure dependence of the fluorescence signal is examined in both steady-state and time-dependent analyses, and a model for evaluation of pressure effects and quenching variations in quantitative imaging measurements in nonpremixed flame environments is presented. The results indicate that increased combustor pressure results in a rapid rise of the volume fraction of hydrocarbon fragments and a decrease in the OH volume fraction.     

NMR investigation of the magnetic susceptibility anisotropy in3He-A

We have investigated transverse continuous wave NMR in a geometry where the modes are influenced by susceptibility anisotropy. The helium sample is separated by mylar foils into layers 12 m thick perpendicular to the external dc magnetic field. In this geometryl is constrained to be parallel to the field andd switches from parallel to perpendicular to the field over a small range of field around the dipole unlocking field. The mode frequencies below this critical field yield a value for the susceptibility anisotropy. Above the critical field the expected negative frequency shift is observed, as well as a positive frequency shift due to bulk material and an unexpected signal close to the Larmor frequency.     

Peering through the lens of high-reliability theory: A competencies driven security culture model of high-reliability organisations

To improve organisational safety and enhance security efficiency, organisations seek to establish a culture of security that provides a foundation for how employees should approach security. There are several frameworks and models that provide a set of requirements for forming security cultures; however, for many organisations, the requirements of the frameworks are difficult to meet, if not impossible. In this research, we take a different perspective and focus on the core underlying competencies that high-reliability organisations (HROs) have shown to be effective in achieving levels of risk tolerance consistent with the goals of a security culture. In doing so we draw on high-reliability theory to develop a Security Culture Model that explains how a firm's supportive and practical competencies form its organisational security culture. To refine and test the model, we conducted a developmental mixed-method study using interviews and survey data with professional managers involved in the information security (InfoSec) programs within their respective HROs. Our findings emphasise the importance of an organisation's supportive and practical competencies for developing a culture of security. Our results suggest that organisations' security cultures are a product of their InfoSec practices and that organisational mindfulness, top management involvement and organisational structure are key to the development of those practices.     

Experimental modelling of free-surface dry granular flows under a centrifugal acceleration field

We investigate the dynamics of granular flows under the action of a centrifugal acceleration field. The granular flows consist of a monodisperse set of glass beads flowing down an inclined plane. The experiments are performed at variable slope angles \(\zeta \) and equivalent centrifugal accelerations \(a_\text {cf}\equiv Ng\). We study the effect of this parameters on the superficial flow velocity u and flow height h. Two trends are observed, by increasing \(\zeta \) and \(a_\text {cf}\), u increases proportionally, and h decreases asymptotically until a constant height. This relation is analysed in terms of the system potential and kinetic energy, leading to the estimation of equivalent impact forces one order of magnitude larger than those observed in small scale 1g laboratory experiments, with the possibility to reach higher forces by increasing N. Finally, considering the trend of u and h, our results suggest a scaling principle of inertial velocity proportional to \(\sqrt{N}\).     

Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation

Normal human diploid fibroblasts have a finite replicative lifespan in vitro, which has been postulated to be a cellular manifestation of aging in vivo. Several studies have shown an inverse relationship between donor age and fibroblast culture replicative lifespan; however, in all cases, the correlation was weak, and, with few exceptions, the health status of the donors was unknown. We have determined the replicative lifespans of 124 skin fibroblast cell lines established from donors of different ages as part of the Baltimore Longitudinal Study of Aging. All of the donors were medically examined and were declared "healthy," according to Baltimore Longitudinal Study of Aging protocols, at the time the biopsies were taken. Both long- and short-lived cell lines were observed in all age groups, but no significant correlation between the proliferative potential of the cell lines and donor age was found. A comparison of multiple cell lines established from the same donors at different ages also failed to reveal any significant trends between proliferative potential and donor age. The rate of [3H]thymidine incorporation and the initial rates of growth during the first few subcultivations were examined in a subset of cell lines and were found to be significantly greater in fetal lines than in postnatal lines. Cell lines established from adults did not vary significantly either in initial growth rate or in [3H]thymidine incorporation. These results clearly indicate that, if health status and biopsy conditions are controlled, the replicative lifespan of fibroblasts in culture does not correlate with donor age.     

Calibrated 0.1-cm(-1) IR emission spectra from 80°N

Spectra from a 0.1-cm(-1) resolution absolutely calibrated emission interferometer installed near Eureka, Northwest Territories, Canada (80°N, 86°W), at the Arctic Stratospheric Observatory are presented. The Michelson-type interferometer has a maximum path difference of 10 cm and uses a liquid-N(2)-cooled HgCdTe detector, which covers the spectral region from 650 to 1250 cm(-1). Spectral intervals containing CO(2), HNO(3), and ozone have been modeled with a line-by-line radiative-transfer code and column amounts retrieved for the latter two constituents. The instrument and initial measurements are described.     

Temperature dependence of macroscopic L-type calcium channel currents in single guinea pig ventricular myocytes

INTRODUCTION: Lowering temperature greatly reduces calcium influx through calcium channels. Studies on a number of tissues demonstrate that the peak inward current, ICa, exhibits Q10 values ranging from 1.8 to 3.5; however, it remains unclear which component(s) of calcium channel gating may give rise to this large temperature sensitivity. Components of gating that may affect channel availability include phosphorylation and changes in [Ca2+]i, processes that vary in pertinence depending on the channel examined. This study addresses this problem by examining the temperature sensitivity (from 34 degrees to 14 degrees C) of cardiac ICa under control conditions, during attenuation or activation of protein kinase A (PKA) activity, and when intracellular [Ca2+] has been elevated. METHODS AND RESULTS: ICa was studied using the whole cell configuration of the patch champ technique. In control, lowering temperature from 34 degrees to 24 degrees C resulted in a shift in the potential for maximum slope (Va) and the peak current (Ymax) toward more positive membrane potentials. The Q10 values for the decrease in Ymax and the macroscopic slope conductance (Gmax), which reflects the number of available channels, were 3.15 +/- 0.19 and 2.57 +/- 0.13, respectively. At 0 mV the Ca2+ current decayed biexponentially, and the two time constants (tau 1 and tau 2) showed Q10 values of 1.79 +/- 0.21 and 2.06 +/- 0.38, while their contribution to the total current (I1 and I2) showed a Q10 of 5.99 +/- 0.83 and 1.61 +/- 0.22. In myocytes loaded with inhibitors of the PKA cycle sufficient to inhibit the increase of ICa to 1 microM isoprenaline, the Q10 values for some of the kinetic parameters were increased with the Q10 for I1 increasing to 17.06 +/- 3.48. Stimulation of ICa by exposing myocytes to 1 microM isoprenaline reduced the temperature sensitivity of Ymax, Gmax and I1, yielding respective values of 2.00 +/- 0.18, 1.85 +/- 0.07, and 2.04 +/- 0.15. Raising [Ca2+]i to enhance Ca2+i-dependent inactivation, while affecting inactivation and activation kinetics, affected temperature sensitivity little compared to control. The Q10 for time to peak changed little under experimental conditions (2.3 to 2.4) CONCLUSIONS: Increasing the phosphorylated states of calcium channels, but not Ca2+i-dependent inactivation, reduces temperature sensitivity of certain gating parameters. The data suggest that the rate of the transitions between the unavailable and also between the various closed states are changed in the opposite direction to that induced by PKA-dependent phosphorylation. Processes, e.g., inhibitory mechanisms, may be involved to maintain channels in unavailable or "unphosphorylated" states, and it may be these that contribute to the high Q10 of macroscopic channel currents.     

A Non-Uniform Predictor-Observer for a Networked Control System

International Journal of Control, Automation and Systems - This paper presents a Non-Uniform Predictor-Observer (NUPO) based control approach in order to deal with two of the main problems related...     

Global estimates of evapotranspiration and gross primary production based on MODIS and global meteorology data

The simulation of gross primary production (GPP) at various spatial and temporal scales remains a major challenge for quantifying the global carbon cycle. We developed a light use efficiency model, called EC-LUE, driven by only four variables: normalized difference vegetation index (NDVI), photosynthetically active radiation (PAR), air temperature, and the Bowen ratio of sensible to latent heat flux. The EC-LUE model may have the most potential to adequately address the spatial and temporal dynamics of GPP because its parameters (i.e., the potential light use efficiency and optimal plant growth temperature) are invariant across the various land cover types. However, the application of the previous EC-LUE model was hampered by poor prediction of Bowen ratio at the large spatial scale. In this study, we substituted the Bowen ratio with the ratio of evapotranspiration (ET) to net radiation, and revised the RS-PM (Remote Sensing-Penman Monteith) model for quantifying ET. Fifty-four eddy covariance towers, including various ecosystem types, were selected to calibrate and validate the revised RS-PM and EC-LUE models. The revised RS-PM model explained 82% and 68% of the observed variations of ET for all the calibration and validation sites, respectively. Using estimated ET as input, the EC-LUE model performed well in calibration and validation sites, explaining 75% and 61% of the observed GPP variation for calibration and validation sites respectively.Global patterns of ET and GPP at a spatial resolution of 0.5° latitude by 0.6° longitude during the years 2000-2003 were determined using the global MERRA dataset (Modern Era Retrospective-Analysis for Research and Applications) and MODIS (Moderate Resolution Imaging Spectroradiometer). The global estimates of ET and GPP agreed well with the other global models from the literature, with the highest ET and GPP over tropical forests and the lowest values in dry and high latitude areas. However, comparisons with observed GPP at eddy flux towers showed significant underestimation of ET and GPP due to lower net radiation of MERRA dataset. Applying a procedure to correct the systematic errors of global meteorological data would improve global estimates of GPP and ET. The revised RS-PM and EC-LUE models will provide the alternative approaches making it possible to map ET and GPP over large areas because (1) the model parameters are invariant across various land cover types and (2) all driving forces of the models may be derived from remote sensing data or existing climate observation networks.