Visual insights into high-resolution earthquake Simulations.

This study focuses on the visualization of a series of large earthquake simulations collectively called TeraShake. The simulation series aims to assess the impact of San Andreas Fault earthquake scenarios in Southern California. We discuss the role of visualization in gaining scientific insight and aiding unexpected discoveries.     

Microscale analysis of glycosphingolipids by TLC blotting/secondary ion mass spectrometry: a novel blood group A-active glycosphingolipid and changes in glycosphingolipid expression in rat mammary tumour cells with different metastatic potentials

The glycosphingolipid compositions of rat mammary tumour cell lines with different metastatic potentials for the lung [a parental tumour cell line (MTC) and its subclones MTLn2 (a non metastatic subclone) and MTLn3 (a subclone with high metastatic potential to the lung)] were studied using a newly developed TLC blotting/secondary ion mass spectrometry system and crude glycosphingolipids obtained from 0.5-1 x 10(7) cells of each cell line. GM3 and GM2 were the major components of the MTC cell line, but they were very minor components in the MTLn2 and MTLn3 cell lines, GDla being the major ganglioside HexNAc-fucosyl-GMla was found in the MTLn2 cells by the TLC blotting/SIMS method, and the terminal sugar linkage was shown to be a blood group A-type structure by immunostaining. These findings suggest that the ganglioside is a novel type of blood group A-active ganglioside, GalNAc alpha 1-3(fuc alpha 1 -2)GMla. No blood group A-active lipid was present in MTLn3 cells, whereas Hex-GMla and neutral glycosphingolipids with more than 5 sugar residues were.     

Superplasticity in a high strength powder aluminum

The superplastic properties of a rapidly solidified, high strength P/M Al alloy and the same alloy reinforced with SiC particulates (SiC _p ) have been studied. To prepare superplastic test materials, a matrix alloy powder of composition 7.2Zn-2.4Mg-2Cu-0.2Zr-0.12Cr-0.2Co (Kaiser PM-64) and the powder mixed with 10 to 20 vol pct SiC _p (~5 μm diameter) were thermomechanically processed to very fine equiaxed grain structures of ~6 μm and ~8 μm, respectively. Superplasticity in these materials was evaluated by characterizing (1) high temperature stability, (2) dynamic grain growth, (3) strain rate sensitivity, (4) flow stress behavior, (5) cavitation and cavitation control, and (6) total superplastic strain. It was observed that the PM-64 alloy could achieve a total elongation of over 800 pct, while the SiC_p reinforced alloy could attain an elongation greater than 500 pct before failure. Also, it was shown that with the use of hydrostatic pressure during superplastic flow, cavitation could be controlled. Observations were made of the effect SiC _p reinforcement particles had on the superplastic flow stress behavior. Interpretations are proposed to explain the role of particulates during superplastic straining.     

Thermoplastic elastomeric composition based on maleic anhydride–grafted ground rubber tire

Ground rubber tire (GRT) powder was maleated in an internal mixer using maleic anhydride and dicumyl peroxide at 160°C. Maleated GRT was characterized by using X‐ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, wettability, and differential scanning calorimetry. The physical properties of the dynamically vulcanized 60 : 40, rubber : plastic composition based on acrylated high‐density polyethylene as the plastic phase and ethylene propylene diene rubber containing maleated GRT as the rubber phase were found to be greater than the corresponding composition containing nonmaleated GRT. The blend was found to be reprocessable, like themoplastic elastomers. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 370–378, 2002; DOI 10.1002/app.10348     

Routing of a hazmat truck in the presence of weather systems

This paper focuses on the effects of weather systems on hazmat routing. We start by analyzing the effects of a weather system on a vehicle traversing a single link. This helps characterize the time-dependent attributes of a link due to movement of the weather systems. This analysis is used as a building block for the problem of finding a least risk path for hazmat transportation on a network exposed to such weather systems. Several methods are offered to solve the underlying problem, and computational results are reported. We draw two conclusions from this paper. First, it is possible to determine the time-dependent attributes for links on a network provided that some assumptions on the nature of the weather system are made. Second, heuristics can provide effective solutions for practical size problems while allowing for parking the vehicle to avoid weather system effects.     

Differential regulation by hematopoietic growth factors of apoptosis and mitosis in acute myeloblastic leukemia cells

We evaluated the effects of various hematopoietic growth factors (HGFs) on the prevention of apoptosis in blasts from 19 patients with acute myeloblastic leukemia (AML) by assessing DNA ladder formation. After incubation without HGF, apoptosis was noted in all but two patients. HGFs prevented, did not affect, or enhanced apoptosis in 39 (60%), 14 (22%), or 12 (18%) of 65 suspension cultures, respectively. HGFs that prevented apoptosis also stimulated and/or synergized blast colony formation in 35 of 39 corresponding methylcellulose cultures. HGFs that alone stimulated colony formation also prevented apoptosis in all but two of 28 corresponding suspension cultures. In contrast, HGFs that did not prevent apoptosis also failed to stimulate growth in 17 of 26 corresponding methylcellulose cultures. HGFs that enhanced apoptosis alone never stimulated colony formation. After incubation, we noted enhanced c-fos and cjun genes as well as induction of p21 protein. An appropriate dose of HGF elevated c-fos, reduced c-jun and p21, induced G1/S transition, and inhibited apoptosis. In two patients, apoptosis was not induced after incubation. Cells not treated with HGF expressed no c-fos, c-jun, or c-myc, and remained in G0/G1. Taken together, our results support the conclusion that not only c-fos, cjun, and c-myc, but also p53 and p21 are required for blast apoptosis. HGF differentially prevents apoptosis and induces mitosis, and both events seem to be integral to the self-renewal of AML clonogenic cells.     

Component commonality effects on inventory costs

In this paper we study the effects of increasing component commonality for a single-period model. A two-product, two-level configuration under a general component cost structure is considered. The economic implications of replacing different products' components by common components are analyzed. We develop optimal solutions for the Commonality and Non-Commonality (Basic) Models and provide bounds on the total savings resulting from using commonality. We demonstrate, under general and specific component cost structures, that some forms of commonality may not always be a preferred strategy. Furthermore, we present conditions under which commonality should not be used. Finally, an extension to the two-product multicomponent model is provided.     

A two-stage MMSE multiuser decision feedback detector using successive/parallel interference cancellation

In this paper, we present a novel two-stage minimum-mean-squared-error (MMSE) multiuser decision feedback detector (DFD) for code division multiple access systems working in the frequency-selective multipath fading environment. The first stage of the proposed cascaded structure is the noise-predictive successive DFD (NP-S-DFD), in which the active users are detected successively using the conventional bell labs layered space-time (BLAST) ordering criterion. The second stage includes an adaptive successive/parallel DFD (SP-DFD), which uses the tentative decisions obtained at the first stage for multiuser interference cancellation and data detection. Therefore, the proposed two-stage DFD may be called noise-predictive successive SP-DFD (NP-S-SP-DFD). Simulation results are presented to demonstrate the substantial improvement in the bit error rate performance of NP-S-SP-DFD over the conventional single-stage and cascaded DFDs. It may be inferred that the proposed DFD provides additional performance gain, when the order in which the users are detected is optimized according to the BLAST ordering based on MMSE criterion.