New Functional Polymers and Materials Based on 2,2′:6′,2″‐Terpyridine Metal Complexes

New inorganic–organic hybrid structures based on metal complexes have become of increasing interest over the last few decades in the search for new materials. Many different polypyridyl metal complexes have been investigated. Recently, a strong increase in interest regarding 2,2′:6′,2″‐terpyridine has been observed. In particular, octahedral bis‐2,2′:6′,2″‐terpyridine metal complexes offer the advantages of increased symmetry and, in the case of ruthenium(III )/ruthenium(II ) complexation, an entrance to a directed complexation technique. Apart from the combination with polymeric systems, ordered inorganic–organic structures on surfaces are becoming better understood concurrently with the development of sophisticated nanotechnology characterization techniques. There are many ongoing efforts that include terpyridine complex structures, especially concerning photophysical processes such as solar light to energy conversion. This review deals with the incorporation of terpyridine complexes into polymeric structures such as poly(ethylene glycol), poly(styrene), dendrimers, biomacromolecules, micelles, and resins, as well as the combination of terpyridine complexes with surfaces for electrocatalytic, photophysical, and self‐assembly purposes.     

Mobilization of peripheral blood stem cells in children using G-CSF after carboplatin containing myelosuppressive chemotherapy

PURPOSE: Peripheral blood stem cell (PBSC) apheresis provides an alternative to autologous marrow harvest as a source of hematologic stem cells for transplantation in children with solid tumors. PATIENTS AND METHODS: Eight children with metastatic or recurrent solid tumors underwent 27 apheresis procedures. Recovery from myelosuppressive chemotherapy occurred without continuous daily growth factor support prior to mobilization. Granulocyte colony stimulating factor (G-CSF) at 16 microgs/kg/day was used to increase stem cells in the peripheral circulation. CD 34 positive cells, mononuclear cells (MNC), and CFU-GM were measured in the apheresis products. Prior chemotherapy was examined as a clinical factor that affected PBSC yield. RESULTS: A significant correlation was found between CD 34+/kg and CFU-GM/kg of the products (r = 0.758, P < 0.001). Patients receiving cumulative doses of carboplatin over 1,600 mg/m2 produced adequate MNC (1 x 10(8)/kg) but yielded significantly less CD 34+ cells or CFU-GM than those patients receiving less carboplatin. Prior doses of etoposide and ifosfamide did not effect PBSC yield. CONCLUSIONS: The mobilization technique was well tolerated, and the products obtained produced trilineage engraftment in the patients that underwent peripheral blood stem cell transplantation. Peripheral blood stem cell apheresis in children can be optimized by selection of appropriate candidates and mobilization with G-CSF after an absence of hematopoietic growth factor support.     

Comparison of entropy and complexity measures for the assessment of depth of sedation

Entropy and complexity of the electroencephalogram (EEG) have recently been proposed as measures of depth of anesthesia and sedation. Using surrogate data of predefined spectrum and probability distribution we show that the various algorithms used for the calculation of entropy and complexity actually measure different properties of the signal. The tested methods, Shannon entropy (ShEn), spectral entropy, approximate entropy (ApEn), Lempel-Ziv complexity (LZC), and Higuchi fractal dimension (HFD) are then applied to the EEG signal recorded during sedation in the intensive care unit (ICU). It is shown that the applied measures behave in a different manner when compared to clinical depth of sedation score--the Ramsay score. ShEn tends to increase while the other tested measures decrease with deepening sedation. ApEn, LZC, and HFD are highly sensitive to the presence of high-frequency components in the EEG signal.     

CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding

Both hypothalamic microglial inflammation and melanocortin pathway dysfunction contribute to diet-induced obesity (DIO) pathogenesis. Previous studies involving models of altered microglial signaling demonstrate altered DIO susceptibility with corresponding POMC neuron cytological changes, suggesting a link between microglia and the melanocortin system. We addressed this hypothesis using the specific microglial silencing molecule, CX3CL1 (fractalkine), to determine whether reducing hypothalamic microglial activation can restore POMC/melanocortin signaling to protect against DIO. We performed metabolic analyses in high fat diet (HFD)-fed mice with targeted viral overexpression of CX3CL1 in the hypothalamus. Electrophysiologic recording in hypothalamic slices from POMC-MAPT-GFP mice was used to determine the effects of HFD feeding and microglial silencing via minocycline or CX3CL1 on GFP-labeled POMC neurons. Finally, mice with hypothalamic overexpression of CX3CL1 received central treatment with the melanocortin receptor antagonist SHU9119 to determine whether melanocortin signaling is required for the metabolic benefits of CX3CL1. Hypothalamic overexpression of CX3CL1 increased leptin sensitivity and POMC gene expression, while reducing weight gain in animals fed an HFD. In electrophysiological recordings from hypothalamic slice preparations, HFD feeding was associated with reduced POMC neuron excitability and increased amplitude of inhibitory postsynaptic currents. Microglial silencing using minocycline or CX3CL1 treatment reversed these HFD-induced changes in POMC neuron electrophysiologic properties. Correspondingly, blockade of melanocortin receptor signaling in vivo prevented both the acute and chronic reduction in food intake and body weight mediated by CX3CL1. Our results show that suppressing microglial activation during HFD feeding reduces DIO susceptibility via a mechanism involving increased POMC neuron excitability and melanocortin signaling.     

Modelization of hybrid systems with hydrogen and renewable energy oriented to electric propulsion in sailboats

This paper presents a conceptual model of a hybrid electric sailboat in which energy from electric grid is stored in batteries and energy from renewable energies (eolic, solar and hydro) is stored as hydrogen. The main objective of this model is to study the viability of electrifying traditional sailboats with internal combustion engines into hybrid systems with batteries and fuel cell. The most important advantage of this design is the possibility to reduce up to zero emissions of traditional sailboat. Conversion of renewable energy to hydrogen is performed through an electrolyzer and post conversion to energy is carried out by a fuel cell. The fuel cell with the batteries forms the hybrid system (batteries-fuel cell) for propulsion electrical energy supply. In order to model the boat dynamic and energy systems, modular mathematical models were developed under Matlab^®-Simulink^®, using a fixed-step solver for the simulation of global model. A simulated logic controller manages the global model. In this paper, many models have been used: some of them are based in literature models and others were developed from experimental data. A control strategy has also been developed to manage energy flows and then it has been embedded to Matlab^® language. The global model permits test the performance of the sailboat.     

The work–family interface and turnover intentions over the course of project-oriented assignments abroad

The work–family interface is a highly relevant, yet underexposed issue in project management. When projects require family-separation, work demands are likely to conflict with family life and the consequences may be neither beneficial for (project) organizations nor for families. The aim of this study was twofold: a) to assess within-person changes over time in employees' work–family conflict experiences, relationship satisfaction, and turnover intentions and b) to examine the interrelations between these variables, over the course of a project that requires family-separation. Quantitative data were collected among military personnel before and after their four to six months assignments abroad. The results revealed that relationship satisfaction among military personnel had decreased significantly and turnover intentions had increased significantly over time. Moreover, employees who experienced higher levels of work–family conflict reported lower levels of relationship satisfaction and higher levels of turnover intentions. Understanding the interrelations may help managing projects in a way that benefits project organizations as well as employees and their families, who are critical to its performance and success.     

Mechanical properties of freely suspended semiconducting graphene-like layers based on MoS2

We fabricate freely suspended nanosheets of molybdenum disulphide (MoS₂) which are characterized by quantitative optical microscopy and high-resolution friction force microscopy. We study the elastic deformation of freely suspended nanosheets of MoS₂ using an atomic force microscope. The Young''s modulus and the initial pre-tension of the nanosheets are determined by performing a nanoscopic version of a bending test experiment. MoS₂ sheets show high elasticity and an extremely high Young''s modulus (0.30 TPa, 50% larger than steel). These results make them a potential alternative to graphene in applications requiring flexible semiconductor materials.PACS, 73.61.Le, other inorganic semiconductors, 68.65.Ac, multilayers, 62.20.de, elastic moduli, 81.40.Jj, elasticity and anelasticity, stress-strain relations.     

Membrane treatment of side-stream cooling tower water for reduction of water usage

A pilot study was conducted to determine whether membrane treatment on a side stream of recirculating cooling-tower water could reduce overall water usage and discharge. The treated permeate was returned to the cooling tower while the concentrate was discharged to the sanitary sewer. Flow rates, pressures and water chemistry were monitored. The pilot demonstrated potential substantial water savings. Maximum make-up water and discharge reduction were 16% and 49%, respectively. As high as possible permeate recovery is needed to maximize water conservation. Silica scaling on the membranes limited water savings in this pilot. Development of membranes with a solute-rejection capacity less than the 92% average of the membranes used in the pilot would assist in optimizing water savings. Decreased water outlays compensated for the additional energy used by membrane treatment. Scaling control is critical for economic operation.     

Reduced Carbon and Energy Footprint in Highway Operations: The Highway Energy Assessment (HERA) Methodology

Global demand for mobility is increasing and the environmental impact of transport has become an important issue in transportation network planning and decision-making, as well as in the operational management phase. Suitable methods are required to assess emissions and fuel consumption reduction strategies that seek to improve energy efficiency and furthering decarbonization. This study describes the development and application of an improved modeling framework – the HERA (Highway EneRgy Assessment) methodology – that enables to assess the energy and carbon footprint of different highways and traffic flow scenarios and their comparison. HERA incorporates an average speed consumption model adjusted with a correction factor which takes into account the road gradient. It provides a more comprehensive method for estimating the footprint of particular highway segments under specific traffic conditions. It includes the application of the methodology to the Spanish highway network to validate it. Finally, a case study shows the benefits from using this methodology and how to integrate the objective of carbon footprint reductions into highway design, operation and scenario comparison.