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951.
Ned Sauthoff Charles Baker Dan Baker Roger Bengston Everett Bloom James Drake Andy Faltens Robert Granetz James Lyon Peter Mioduszewski William Nevins Dale Smith Michael Ulrickson James Van Dam Glen Wurden Kenneth Young 《Journal of Fusion Energy》2000,19(1):65-79
This report was prepared by a Working Group at the request of the U.S. Department of Energy, Office of Fusion Energy Sciences in 1997. The report addresses technical opportunities for mutually beneficial collaboration between the United States and other international fusion research programs. A number of outstanding opportunities are discussed. 相似文献
952.
Qi-Yao Wei Andy T. Y. Lau Hai-Ying Mo Qiu-Hua Zhong Xiao-Yun Zhao Fei-Yuan Yu Jin Han Yu-Yao Wu Yan-Ming Xu 《International journal of molecular sciences》2023,24(1)
The cytochrome P450s (CYP450s) include key oxidative enzymes involved in the metabolism of various carcinogens and anticancer drugs. Bioinformatic studies have demonstrated the association of CYP3A43 with liver cancer and ovarian cancer. However, the biological function of CYP3A43 in tumor progression remains unclear. To further reveal the role of CYP3A43 in tumor progression, we first analyzed the data from the UALCAN database and found that CYP3A43 was negatively correlated to the cancer staging and lymph node metastasis of lung adenocarcinoma (LUAD). We established stable CYP3A43-knockdown LUAD H1299 cell line and found that its knockdown enhanced cell proliferation, colony formation, and migration in vitro, and promoted the growth of tumor xenograft in vivo. Interestingly, when CYP3A43 was ectopically-expressed in the LUAD cell lines, decreased cell proliferation and ERK1/2 phosphorylation level were observed. Lastly, we also identified CYP3A43 co-expressed genes in LUAD from LinkedOmics database followed by GO and KEGG analyses. In conclusion, our results indicate the unprecedented role of CYP3A43 in the suppression of LUAD and provide new possibilities for targeted therapy of this life-threatening disease. 相似文献
953.
954.
Bingyu Bai Chencheng Xue Yue Wen Jet Lim Zhicheng Le Yufeng Shou Sunmi Shin Andy Tay 《Advanced functional materials》2023,33(40):2303373
Cryopreservation strives to maximize the viability and biofunctionality of cells and tissues by cooling them to a subzero temperature to facilitate storage and delivery. This technology has enabled clinics and labs to preserve rare and crucial samples and is poised to become more important with rising interest in cell therapy. Here, the biological impact of cooling rates on different cellular components is first described, paying special emphasis on the differences between slow cooling and vitrification with a heat transfer perspective based on the Biot number. This is followed by an overview of various classes of chemical-based cryoprotective agents including small molecules, antifreeze proteins, hydrogels, and cryoprotective nanomaterials. Most importantly, fundamental concepts of cryopreservation including Mazur's “two-factor hypothesis” are revisited, gaps in them are highlighted, and experiments to validate reported claims to deepen mechanistic understanding of cryoprotection are proposed. A matric is also introduced to assess the suitability of biomaterials for use in cell therapy to support manufacturers in making strategic choices for storing clinical samples. It is believed that this review would inspire readers to scrutinize fundamental concepts in cryopreservation to facilitate the development of new cryoprotective materials and technologies to support the emerging cell manufacturing and therapy industry. 相似文献
955.
众所周知,过量的环境噪声会令人失眠、焦虑、或引发心脏病等。根据世界卫生组织报告,全球各国都有一定数量的人已达至这水平,很多人是受环境噪声的影响。当大家在追求提高经济效益及生活质素的同时,各国为了建立智慧城市,有着不同的思维和构思去改善环境噪声,其中利用轨道交通工具作集体运输被各国视为一石二鸟的聪明出行方法。文章旨在分享全球在这方面的现状和趋势。 相似文献
956.
316L and Cu-based inks are developed to 3D-printed tetrachiral auxetic structures. The main objectives of the work are to study the effects of powders composition and powder:binder volume ratio on rheological properties and printability of the inks. Following these results, customized Gcode is developed using FullControl Gcode Designer open-source software to 3D print intricate tetrachiral auxetic structures. The results reported in this work show how powder composition (316L versus Cu) has less effect on the inks’ rheological behavior than powder size distribution and powders:binder volume ratio. In terms of rheological parameters, the zero-shear rate viscosity mainly affects the capability of the printed ink to retain its shape after printing, while the yield stress affects the printability. The printed and sintered auxetic structures achieve the intended lattice-geometry design. 相似文献