Natalie Munding;Magdalena Fladung;Yi Chen;Marc Hippler;Anthony D. Ho;Martin Wegener;Martin Bastmeyer;Motomu Tanaka; 《Advanced functional materials》2024,34(20):2470111

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Li-Tao Zhu  Anthony Wachs 《American Institute of Chemical Engineers》2023,69(11):e18209

The development of hydrodynamic force/torque closure models with physical fidelity is crucial for ensuring reliable Euler–Lagrange simulations in particle-laden flows. Our previous work (Seyed-Ahmadi and Wachs. J Fluid Mech. 2020;900:A21) proposed a microstructure-informed probability-driven point-particle (MPP) method to construct a data-driven particle-position-dependent closure model, incorporating the effect of surrounding particle positions on forces/torques. However, the MPP model is not pluggable in Euler–Lagrange simulations due to the computation of constant coefficients through linear regression and reliance on statistical arguments to obtain the probability map for a pair of values of solid volume fraction (Φ) and Reynolds number (Re). To overcome this limitation, we propose an interpolated MPP (iMPP) method, involving interpolation in the Φ and Re spaces. Our results demonstrate that the iMPP method can capture over 70% of the total fluctuations in hydrodynamic forces/torques in approximately 97.8% of the tested cases. This advancement contributes to a more versatile closure model suitable for integration into E-L simulations.  相似文献   

    

Houpu Li  Hsin-ya Yang  Narges Asefifeyzabadi  Prabhat Baniya  Andrea Medina Lopez  Anthony Gallegos  Kan Zhu  Tiffany Nguyen  Cristian Hernandez  Ksenia Zlobina  Cynthia Recendez  Hao-Chieh Hsieh  Maryam Tebyani  Héctor Carrión  John Selberg  Le Luo  Moyasar A. Alhamo  Alexie Barbee  Jonathan Orozco  Cathleen Hsieh  Athena M. Soulika  Michael Levin  Narges Norouzi  Marcella Gomez  Min Zhao  Mircea Teodorescu  Roslyn Rivkah Isseroff  Marco Rolandi 《Advanced Materials Technologies》2024,9(7):2301115

The ability to deliver drugs with precise dosages at specific time points can significantly improve disease treatment while reducing side effects. Drug encapsulation for gradual delivery has opened the doors for a superior treatment regimen. To expand on this ability, programming bioelectronic devices to deliver small molecules enables ad-hoc personalized therapeutic profiles that are more complex than gradual release. Here, a wearable bioelectronic device with an integrated electrophoretic ion pump that affords on-demand drug delivery with precise dose control is introduced. Delivery of fluoxetine to wounds in mice result in a 27.2% decrease in the macrophage ratio (M1/M2) and a 39.9% increase in re-epithelialization, indicating a shorter inflammatory phase and faster overall healing. Programmable drug delivery using wearable bioelectronics in wounds introduces a broadly applicable strategy for the long-term delivery of a prescribed treatment regimen with minimal external intervention.  相似文献   

    

Anthony Fazzalari  Cedric Briens  Lauren Tribe 《加拿大化工杂志》2024,102(2):574-584

Biochar, unwashed and washed with a solution of Triton and hydrogen peroxide, was wet drum granulated using molasses binder solutions. Unwashed biochar was very hydrophobic and granulation proceeded through forming liquid marbles and layering. Washing reduced the hydrophobicity of the biochar. The effectiveness of the wash depended on the biochar source; it significantly reduced the hydrophobicity of biochar from woodchips and moderately reduced the hydrophobicity of biochar from flower digestate. Therefore, washed biochar from woodchips was granulated using a hydrophilic mechanism, while washed biochar from digestate was granulated according to a combination mechanism of liquid marbles collapsing and then coalescing. The change in granulation mechanism produced stronger and denser granules with higher yields of granules in the 1–4 mm optimal size range. Washing and then granulating biochar created a product that could be further tailored for optimal soil amendment.  相似文献   

    

Susannah C. Davis  Susan Bobbitt Nolen  Naeun Cheon  Elba Moise  Eric William Hamilton 《工程教育杂志》2023,112(2):284-315

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Leonard Taylor Jr.  Margaret Mastrogiovanni  Joni M. Lakin  Virginia Davis 《工程教育杂志》2023,112(2):365-381

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Cathleen A. Hoel  Sara K. Peterson  Rachel Rose  Eric Telfeyan  Linda A. Boyd  Jae-Hyuk Her  Daniel J. Erno  Chitresh Bhushan  Jessica S. Martinez  Brian M. Davis  Steven Duclos  Gautam Parthasarathy 《Advanced Engineering Materials》2023,25(1):2200956

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Anujan Ramesh  Nilesh Deshpande  Vaishali Malik  Anh Nguyen  Mehak Malhotra  Maharshi Debnath  Anthony Brouillard  Ashish Kulkarni 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(41):2300978

Diagnosis of inflammatory diseases is characterized by identifying symptoms, biomarkers, and imaging. However, conventional techniques lack the sensitivities and specificities to detect disease early. Here, it is demonstrated that the detection of macrophage phenotypes, from inflammatory M1 to alternatively activated M2 macrophages, corresponding to the disease state can be used to predict the prognosis of various diseases. Activatable nanoreporters that can longitudinally detect the presence of the enzyme Arginase 1, a hallmark of M2 macrophages, and nitric oxide, a hallmark of M1 macrophages are engineered, in real-time. Specifically, an M2 nanoreporter enables the early imaging of the progression of breast cancer as predicted by selectively detecting M2 macrophages in tumors. The M1 nanoreporter enables real-time imaging of the subcutaneous inflammatory response that rises from a local lipopolysccharide (LPS) administration. Finally, the M1-M2 dual nanoreporter is evaluated in a muscle injury model, where an initial inflammatory response is monitored by imaging M1 macrophages at the site of inflammation, followed by a resolution phase monitored by the imaging of infiltrated M2 macrophages involved in matrix regeneration and wound healing. It is anticipated that this set of macrophage nanoreporters may be utilized for early diagnosis and longitudinal monitoring of inflammatory responses in various disease models.  相似文献   

Moisturizing at a molecular level – The basis of Corneocare     

Rainer Voegeli  Anthony V. Rawlings 《International journal of cosmetic science》2023,45(2):133-154

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Mostafa Othman  Tian Zhang  David P. McMeekin  Sebastian O. Fürer  Wenxin Mao  Weilun Li  Andrew D. Scully  Anthony S. R. Chesman  Philip N. H. Nakashima  Udo Bach  Joanne Etheridge 《Solar RRL》2023,7(1):2200852

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