A six-noded element for analysing power-type singularities under thermal loads

The shape functions of a 6-noded triangular element have been derived to model power-type singularities under thermal loads. A number of case studies have been presented, which involve variable-order singularities under mechanical and thermal loads. The results show the usefulness of the element.     

Selecting a requirement determination methodology-contingency approach revisited

Previous research proposed a contingency approach to selecting a particular requirement determination methodology because of the uncertainty that exists in defining application/ organizational information requirements. Recent research has shown that organizations use information to reduce uncertainty, to resolve equivocality, or both. Since the nature of information used to reduce uncertainty is different from that used to resolve equivocality, it is necessary to decide which is needed before starting to design the future system. This paper presents a three step approach to selecting a requirement determination methodology. The first step calls for assessment of the degree of uncertainty and equivocality present in the application. Based on this, an appropriate information acquisition strategy is identified. The third step calls for the selection of RD methodologies that are effective in acquiring the needed information. This approach is illustrated with a set of examples.     

Guidelines for a preliminary dimensioning of a transaction-oriented vsat network

Very small aperture terminal (VSAT) satellite networks have recently emerged as an attractive and cost-effective alternative to traditional terrestrial circuit or packet switching networks for transaction enquiry-response data applications. VSAT star networks are particularly well adapted to this kind of application, offering high link reliability, better flexibility, wide service area coverage and several economic and operational advantages. However, one major drawback associated with satellite links is the relatively high propagation delay, which is about 0·27 s for one hop (ground–satellite-ground). This requires special design and dimensioning optimization in order to keep the response time of the network within acceptable limits. This paper provides guidelines for the dimensioning of such enquiry-response star VSAT networks. Dimensioning refers to determining the minimum transmission bit rates required, on the different terrestrial and satellite segments of the network, for a given network configuration and mean delay requirement. The approach presented in this paper allows network designers to determine, in a simple way, the required modem speeds of the network segments.     

The effect of field modifier blocks on the fast photoneutron dose equivalent from two high-energy medical linear accelerators

High-energy linear accelerators (linacs) have several advantages, including low skin doses and high dose rates at deep-seated tumours. But, at energies more than 8 MeV, photonuclear reactions produce neutron contamination around the therapeutic beam, which may induce secondary malignancies. In spite of improvements achieved in medical linac designs, many countries still use conventional (non-intensity-modulated radiotherapy) linacs. Hence, in these conventional machines, fitting the beam over the treatment volume may require using blocks. Therefore, the effect of these devices on neutron production of linacs needs to be studied. The aim of this study was to investigate the effect of field shaping blocks on photoneutron dose in the treatment plane for two high-energy medical linacs. Two medical linacs, a Saturn 43 (25 MeV) and an Elekta SL 75/25 (18 MeV), were studied. Polycarbonate (PC) films were used to measure the fluence of photoneutrons produced by these linacs. After electrochemical etching of the PC films, the neutron dose equivalent was calculated at the isocentre and 50 cm away from the isocentre. It was noted that by increasing the distance from the centre of the X-ray beam towards the periphery, the photoneutron dose equivalent decreases rapidly for both the open and blocked fields. Increasing the energy of the photons causes an increase in the amount of photoneutron dose equivalent. At 25 MeV photon energy, the lead blocks cause a meaningful increase in the dose equivalent of photoneutrons. In this research, a 30% increase was seen in neutron dose contribution to central axis dose at the isocentre of a 25 MeV irregular field shaped by lead blocks. It is concluded that lead blocks must be considered as a source of photoneutron production when treating irregular fields with high-energy photons.     

Exact and approximate Fourier rebinning algorithms for the solution of the data truncation problem in 3-D PET

This paper presents an extended 3-D exact rebinning formula in the Fourier space that leads to an iterative reprojection algorithm (iterative FOREPROJ), which enables the estimation of unmeasured oblique projection data on the basis of the whole set of measured data. In first approximation, this analytical formula also leads to an extended Fourier rebinning equation that is the basis for an approximate reprojection algorithm (extended FORE). These algorithms were evaluated on numerically simulated 3-D positron emission tomography (PET) data for the solution of the truncation problem, i.e., the estimation of the missing portions in the oblique projection data, before the application of algorithms that require complete projection data such as some rebinning methods (FOREX) or 3-D reconstruction algorithms (3DRP or direct Fourier methods). By taking advantage of all the 3-D data statistics, the iterative FOREPROJ reprojection provides a reliable alternative to the classical FOREPROJ method, which only exploits the low-statistics nonoblique data. It significantly improves the quality of the external reconstructed slices without loss of spatial resolution. As for the approximate extended FORE algorithm, it clearly exhibits limitations due to axial interpolations, but will require clinical studies with more realistic measured data in order to decide on its pertinence.     

STUDY OF MIXED-CONVECTION HEAT TRANSFER FROM AN IMPINGING JET TO A SOLID WALL USING A FINITE-ELEMENT METHOD—APPLICATION TO COOKTOP MODELING

The mixed-convection flow from a hot vertical impinging jet on a colder horizontal disc has been studied. The geometry is analogous to a conventional burning gas cooktop. A numerical simulation of the system has been carried out using the finite-element method to study the dependence of fluid flow and heat transfer on the geometric, thermal, and fluid flow parameters. Results show that heat transfer efficiency versus several parameters such as inlet velocity magnitude and flue gas temperature has an optimum value, in which heat transfer efficiency is maximum. With thermal conductivity of the solid wall, velocity angle, and solid wall diameter heat transfer efficiency has increasing behavior. Finally, with solid wall height and solid wall thickness, heat transfer efficiency has diminishing behavior.     

Distance-based consensus method for ABC analysis

A distance-based multi-criteria consensus framework on the concepts of ideal and negative-ideal solutions is presented for the ABC analysis of inventory items. This article demonstrates a way of classifying inventory items using the TOPSIS (‘Technique for Order Preference by Similarity to Ideal Solution’) model. The methodology has been applied in a pharmaceutical company located in the heart of Kolkata, India. The technique takes into account various conflicting criteria having incommensurable units of measurement. Unit cost, lead time, consumption rate, perishability of items and cost of storing of raw materials have been considered for the case study. By using TOPSIS, the items are ranked in categories A, B and C. The suitability, practicability and effectiveness of the TOPSIS method used in ABC classification have been judged using the analysis of variance (ANOVA) technique. A simulation model has been used to compare the proposed model with that of the traditional ABC classification technique.     

A fully fuzzified,intelligent theory-of-constraints product-mix decision

The present research work outlines a fuzzified approach using fuzzy linear programming (FLP) using a suitably designed smooth logistic membership function (MF) for finding fuzziness patterns at disparate levels of satisfaction for theory of constraints-based (TOC) product-mix decision problems. The objective of the present work is to find fuzziness patterns of product-mix decisions with disparate levels of satisfaction of the decision-maker (DM). Another objective is to provide a robust, quantified monitor of the level of satisfaction among DMs and to calibrate these levels of satisfaction against DM expectations. Product-mix decision should take into account considerations such as the DM's level of satisfaction (sometimes called ‘emotions’) in order to make the decision a robust one. Sensitivity of the decision has been focused on a bottleneck-free, optimal product-mix solution of a TOC problem. The inefficiency of traditional linear programming (LP) in handling multiple-bottleneck problems using TOC is discussed using an illustrative example. Relationships among the degree of fuzziness, level of satisfaction and the throughput of modified TOC guide decision-makers (DM) under tripartite fuzzy environment in obtaining their product-mix choice trading-off with a pre-determined allowable fuzziness.     

Preparation,Optimization, and Characterization of Topotecan Loaded PEGylated Liposomes Using Factorial Design

This study reports the development of liposomal system for a potent antitumor drug, topotecan. To achieve this goal conventional and PEGylated liposomes were prepared according to a factorial design by hydration method followed by extrusion. Parameters such as type of lipid, percentage of cholesterol, percentage of phosphatidylglycerols, percentage of polyethylene glycol (PEG)-lipids, and drug to lipid molar ratio were considered as important factors for the optimizing the entrapment and retention of topotecan inside the liposomes. The size and zeta-potential of the PEGylated and conventional liposomes were measured by particle size analyzer and zeta-potentiometer, respectively. The stability and release characteristics of PEGylated liposome loaded topotecan were compared with conventional liposomes and free topotecan.

The optimized PEGylated [distearoyl phosphatidylcholine (DSPC)/cholesterol/ distearoyl phosphatidylglycerol (DSPG)/ distearoyl phosphatidylethanolamine-PEG₂₀₀₀ (DSPE-PEG₂₀₀₀); 7:7:3:1.28] and related conventional [DSPC/cholesterol/DSPG; 7:7:3] liposomes showed a narrow size distribution with a polydipersity index of 0.15 and 0.10, an average diameter of 103.0 ± 13.1 and 95.2 ± 11.10 nm, and with drug loading of 11.44 and 6.21%, respectively. Zeta-potential was ?10 ± 2.3 and ?22 ± 2.8 mV for PEGylated and conventional liposomes, respectively. The results of stability evaluation showed that the lactone ring of topotecan was notably preserved upon liposome encapsulation. PEGylated liposomes containing topotecan showed a significant decrease (P < 0.001) in release rate in comparison with conventional leptosomes. These results indicate the suitability of PEGylated liposomes in controlling topotecan release.

The prepared liposomes (especially PEGylated liposomes) as those described here may be clinically useful to stabilize and deliver topotecan for the treatment of cancer.     

Reliability analysis of the flat-topped array beam FSO communication link

Free-space optical communication systems are affected by turbulent atmosphere. The atmospheric transmission is affected by absorption, scattering and turbulence. In this paper, the effects of absorption and scattering are taken into account using Beer’s law and the effects of turbulence are considered in calculating the average intensity distribution. An analytical expression for the average intensity distribution of a partially coherent flat-topped array (PCFTA) beam in turbulent atmosphere is derived based on the extended Huygens–Fresnel principle. The average intensity, power in bucket, signal to noise ratio, and bit error rate of this kind of beam are investigated in details. It is shown by numerical results and analytical methods that the average intensity and link parameters of PCFTA beams change during propagation and these changes are dependent upon both source parameters and weather conditions.