Modular experimental setup for real‐time analysis of emergent behavior in networks of Chua's circuits

This paper describes the design, realization and use of an analogical, fully reconfigurable experimental setup to analyze the complex dynamics of networks of chaotic circuits. It reports details of the implementation and characterization of the setup, together with representative results, showing its flexibility and potential. The setup allows to choose arbitrarily the coupling strength and interconnection structure among the circuits, the type of link and to select the parameters of the node dynamics. It has a modular structure, and it can accommodate up to 32 nodes interconnected by at most 32 links. The collective dynamics of a relatively large set of different network structures and configurations has been investigated using the setup. Synchronization, pattern formation and other interesting collective phenomena were observed experimentally, their evidence being reported here as an illustration of the potential of the proposed setup. Copyright © 2015 John Wiley & Sons, Ltd.     

Depth Discontinuities by Pixel-to-Pixel Stereo

An algorithm to detect depth discontinuities from a stereo pair of images is presented. The algorithm matches individual pixels in corresponding scanline pairs, while allowing occluded pixels to remain unmatched, then propagates the information between scanlines by means of a fast postprocessor. The algorithm handles large untextured regions, uses a measure of pixel dissimilarity that is insensitive to image sampling, and prunes bad search nodes to increase the speed of dynamic programming. The computation is relatively fast, taking about 600 nanoseconds per pixel per disparity on a personal computer. Approximate disparity maps and precise depth discontinuities (along both horizontal and vertical boundaries) are shown for several stereo image pairs containing textured, untextured, fronto-parallel, and slanted objects in indoor and outdoor scenes.     

Shape and motion from image streams under orthography: a factorization method

Inferring scene geometry and camera motion from a stream of images is possible in principle, but is an ill-conditioned problem when the objects are distant with respect to their size. We have developed a factorization method that can overcome this difficulty by recovering shape and motion under orthography without computing depth as an intermediate step.An image stream can be represented by the 2F×P measurement matrix of the image coordinates of P points tracked through F frames. We show that under orthographic projection this matrix is of rank 3.Based on this observation, the factorization method uses the singular-value decomposition technique to factor the measurement matrix into two matrices which represent object shape and camera rotation respectively. Two of the three translation components are computed in a preprocessing stage. The method can also handle and obtain a full solution from a partially filled-in measurement matrix that may result from occlusions or tracking failures.The method gives accurate results, and does not introduce smoothing in either shape or motion. We demonstrate this with a series of experiments on laboratory and outdoor image streams, with and without occlusions.     

Li4SiO4 pebbles reduction in He + 0.1% H2 purge gas and effects on tritium release properties

Lithium orthosilicate reduction was examined by Temperature Programmed Reaction (TPR) and Temperature Programmed Desorption (TPD) methods performed in He (or Ar) + H₂ purge gas flowing through pebble bed specimens. The parameters governing the kinetics and the steady-state of the reduction process to Li₄SiO_4−x were determined at 800°C. The level x of the O-vacancy concentration at steady-state (of the order of 1.5×10⁻³ mole fraction) was found to be compatible with the impurities content in the specimens. Pebble pre-annealing treatments were found to affect the microstructure and the reduction mechanism. Post-irradiation tritium release by TPD tests were performed on both stoichiometric and reduced pebbles with similar results. Tritium release properties of this breeder system seem to be independent from the material reduction state (x).     

BETaaS: A Platform for Development and Execution of Machine-to-Machine Applications in the Internet of Things

Wireless Personal Communications - The integration of everyday objects into the Internet represents the foundation of the forthcoming Internet of Things (IoT). Smart objects will be the building...     

NSCLC as the Paradigm of Precision Medicine at Its Finest: The Rise of New Druggable Molecular Targets for Advanced Disease

Standard treatment for advanced non-small cell lung cancer (NSCLC) historically consisted of systemic cytotoxic chemotherapy until the early 2000s, when precision medicine led to a revolutionary change in the therapeutic scenario. The identification of oncogenic driver mutations in EGFR, ALK and ROS1 rearrangements identified a subset of patients who largely benefit from targeted agents. However, since the proportion of patients with druggable alterations represents a minority, the discovery of new potential driver mutations is still an urgent clinical need. We provide a comprehensive review of the emerging molecular targets in NSCLC and their applications in the advanced setting.     

Chronic Hyperkaliemia in Chronic Kidney Disease: An Old Concern with New Answers

Increasing potassium intake ameliorates blood pressure (BP) and cardiovascular (CV) prognoses in the general population; therefore the World Health Organization recommends a high-potassium diet (90–120 mEq/day). Hyperkalaemia is a rare condition in healthy individuals due to the ability of the kidneys to effectively excrete dietary potassium load in urine, while an increase in serum K⁺ is prevalent in patients with chronic kidney disease (CKD). Hyperkalaemia prevalence increases in more advanced CKD stages, and is associated with a poor prognosis. This scenario generates controversy on the correct nutritional approach to hyperkalaemia in CKD patients, considering the unproven link between potassium intake and serum K⁺ levels. Another concern is that drug-induced hyperkalaemia leads to the down-titration or withdrawal of renin-angiotensin system inhibitors (RASI) and mineralocorticoids receptors antagonists (MRA) in patients with CKD, depriving these patients of central therapeutic interventions aimed at delaying CKD progression and decreasing CV mortality. The new K⁺-binder drugs (Patiromer and Sodium-Zirconium Cyclosilicate) have proven to be adequate and safe therapeutic options to control serum K⁺ in CKD patients, enabling RASI and MRA therapy, and possibly, a more liberal intake of fruit and vegetables.