经皮肾镜取石术后肾动脉损伤造影表现及栓塞治疗

【摘要】 目的 探讨经皮肾镜取石术（PCNL）后肾动脉损伤肾动脉造影表现及超选择性肾动脉栓塞术（SRAE）治疗效果。方法 收集2010年1月至2014年6月PCNL术后出现持续性或间歇性肉眼血尿患者共22例,均经肾动脉造影证实为肾动脉损伤,并接受SRAE术治疗,栓塞材料为微弹簧圈。术后随访3个月。结果 22例患者中DSA造影表现为肾动脉假性动脉瘤（RAP）14例（63.6%）,肾动静脉瘘（RAVF）5例（22.7%）,RAP伴发RAVF 3例（13.6%）。SRAE术后肾动脉造影显示病变均达到完全栓塞,所有患者活动性出血停止,技术成功率及有效止血率均为100%。术后随访3个月,22例患者均未见血尿复发及严重并发症。20例患者术后出现不同程度的栓塞综合征。结论 RAP、RAVF是PCNL术后肾动脉损伤的主要类型,采用微弹簧圈行SRAE可作为经保守治疗无效患者的首选治疗方法。     

黄石地区露天矿山边坡分类及其生态修复应用

湖北省黄石地区矿产资源丰富,露天开采矿山众多,存在大量亟待生态修复治理的边坡。根据边坡的岩体岩性、岩体结构类型、坡度、坡向、坡高的组合关系,将黄石地区的露天矿山边坡划分为难治理型、较难治理型、较易治理型、易治理型四类,指出岩质、整体状和块状结构、陡坡及以上、顺层坡、高及超高边坡的生态修复难度较大。露天矿山边坡的类型及生态修复难易程度不同,应本着技术可行性、经济合理性、施工便利性原则,因地制宜地制订生态修复治理方案,以达到修复效果和经济性的协调统一。     

煤矿巷道超前综合物探方法在平朔矿区的应用

针对常规钻探不能全面掌握回采巷道附近地质构造和老空区分布情况的不足,平朔矿区进行了巷道超前综合物探方法试验,分别采用地震映像探测法、TSP超前预报法、双频激电超前预报等方法对4109主、辅巷各位置进行了综合探测。通过分析,初步探明了4109主、辅巷道周围地质构造和老空区分布状况,对指导具体开采活动具有重要意义。     

An Anticipative Recursively Adjusting Mechanism for parallel file transfer in data grids

Data Grids enable the sharing, selection, and connection of a wide variety of geographically distributed computational and storage resources for content needed by large‐scale data‐intensive applications such as high‐energy physics, bioinformatics, and virtual astrophysical observatories. In Data Grids, co‐allocation architectures were developed to enable parallel downloads of data sets from selected replica servers. As Internet is usually the underlying network of a grid, network bandwidth plays as the main factor affecting file transfers between clients and servers. In this paradigm, there are still some challenges that need to be solved, such as to reduce differences in finish times between selected replica servers, to avoid traffic congestion resulting from transferring the same blocks in different links among servers and clients, and to manage network performance variations among parallel transfers. In this paper, we propose the Anticipative Recursively Adjusting Mechanism (ARAM) scheme to adjust the workloads on selected replica servers and handle unpredictable variations in network performance by those servers. Our algorithm is based on using the finish rates for previously assigned transfers to anticipate the bandwidth status for the next section to adjust workloads, and to reduce file transfer times in grid environments. Our approach is useful in grid environments with unstable network link. It not only reduces idle time wasted waiting for the slowest server, but also decreases file transfer completion times. Copyright © 2010 John Wiley & Sons, Ltd.     

基于GIS拆装智能平台的环境监测技术

综合考虑各种环境因素对GIS户外安装及检修的影响,对基于GIS拆装智能平台的环境监测技术进行了研究,提出了满足GIS户外安装及检修的环境要求,设计了一套用于GIS拆装智能平台的的环境检测系统,大大提高了GIS户外安装及检修的质量保证。     

基于Hyper Works的6杆并联机床的优化设计

针对并联机床加工过程中发生共振导致机构变形进而影响零件加工精度的问题,文中以6杆并联机床为研究对象,采用拓扑优化的方法对并联机床床身进行优化。首先确定床身的优化部位为立柱、横架和定台,运用HyperWorks中拓扑优化模块对其优化,通过添加一定的加强筋来整修优化立柱和横架,对立柱的筋板尺寸进一步优化。优化后运用模态分析和谐响应分析进行整机验证,对比优化前后模型,发现优化后的模型总质量减少了17.8%,前三阶共振频率分别增加了19.56%、20.62%、0.091%,共振峰值在X、Y、Z方向降低了49.454%、29.036%、0.0078%。对结果分析可知优化后的并联机床在加工中避免了共振的发生,其加工精度得到了提高。     

烟气超声流量计时间测量准确度校准方法研究

大口径气体超声波流量计广泛应用于烟道排放监测和工业控制等领域。超声波流量计的传播时间测量准确度校准是非实流校准的重要环节,通过建立超声波流量计时间测量准确度校准装置,实现对大口径气体超声流量计传播时间的非实流校准。该文首先提出3种不同的超声流量计传播时间校准方法,分析不同方法的影响因素,其次通过改变探头间距离,对不同探头间距时超声波流量计传播时间的测量误差进行校准。试验结果表明:超声波流量计传播时间的测量误差随距离变化,并确定利用标准声速对超声波流量计传播时间进行修正的方法更为准确,测量结果不确定度为0.2%。     

PD‐1 Blockade for Improving the Antitumor Efficiency of Polymer–Doxorubicin Nanoprodrug

Chemotherapy is well recognized to induce immune responses during some chemotherapeutic drugs‐mediated tumor eradication. Here, a strategy involving blocking programmed cell death protein 1 (PD‐1) to enhance the chemotherapeutic effect of a doxorubicin nanoprodrug HA‐Psi‐DOX is proposed and the synergetic mechanism between them is further studied. The nanoprodrugs are fabricated by conjugating doxorubicin (DOX) to an anionic polymer hyaluronic acid (HA) via a tumor overexpressed matrix metalloproteinase sensitive peptide (CPLGLAGG) for tumor targeting and enzyme‐activated drug release. Once accumulated at the tumor site, the nanoprodrug can be activated to release antitumor drug by tumor overexpressed MMP‐2. It is found that HA‐Psi‐DOX nanoparticles can kill tumor cells effectively and initiate an antitumor immune response, leading to the upregulation of interferon‐γ. This cytokine promotes the expression of programmed cell death protein‐ligand 1 (PD‐L1) on tumor cells, which will cause immunosuppression after interacting with PD‐1 on the surface of lymphocytes. The results suggest that the therapeutic efficiency of HA‐Psi‐DOX nanoparticles is significantly improved when combined with checkpoint inhibitors anti‐PD‐1 antibody (α‐PD1) due to the neutralization of immunosuppression by blocking the interaction between PD‐L1 and PD‐1. This therapeutic system by combining chemotherapy and immunotherapy further increases the link between conventional tumor therapies and immunotherapy.     

超深井水力脉冲空化射流钻井试验研究

在分析超深井水力脉冲空化射流钻井机理的基础上,在塔里木油田中古区块的2口超深井上进行了水力脉冲空化射流钻井现场试验.试验表明:水力脉冲空化射流在不改变原有钻具组合和钻井参数的情况下可以有效提高超深井机械钻速,并且对延长钻头寿命有一定的作用;水力脉冲空化射流发生器性能稳定,使用寿命长,完全可以满足现场需要.     

数字视频监控系统及其应用

介绍了视频监控的发展现状 ,分析了模拟视频监控的缺点 ,对数字视频监控的结构和特点进行了分析和比较 ,并讨论了数字视频监控的发展趋势。