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C Chapron P Devroey JB Dubuisson JL Pouly P Vercellini 《Canadian Metallurgical Quarterly》1997,12(4):867-868
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EF Bernstein FJ Sullivan JB Mitchell GD Salomon E Glatstein 《Canadian Metallurgical Quarterly》1993,20(3):435-453
Radiation therapy exerts both acute and chronic effects on normal tissue included within treatment fields. The physics of radiation therapy and treatment techniques to minimize deleterious effects of radiation are presented. Management of radiation-damaged skin is discussed. Radiation effect on tissue, wound healing, and tumorigenesis also are reviewed. 相似文献
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M Wisard A Bitton P Jichlinski JB Wasserfallen HJ Leisinger 《Canadian Metallurgical Quarterly》1997,86(44):1755-1757
Day surgery in urology is in full growth actually. The present report is based on our first 120 patients. Low post-operative complication rate, patients' satisfaction and economical savings are the main factors for the important increase in this type of surgery. 相似文献
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We demonstrated recently that dominant negative mutants of rat DNA polymerase beta (Pol beta) interfere with repair of alkylation damage in Saccharomyces cerevisiae. To identify the alkylation repair pathway that is disrupted by the Pol beta dominant negative mutants, we studied the epistatic relationship of the dominant negative Pol beta mutants to genes known to be involved in repair of DNA alkylation damage in S. cerevisiae. We demonstrate that the rat Pol beta mutants interfere with the base excision repair pathway in S. cerevisiae. In addition, expression of one of the Pol beta dominant negative mutants, Pol beta-14, increases the spontaneous mutation rate of S. cerevisiae whereas expression of another Pol beta dominant negative mutant, Pol beta-TR, does not. Expression of the Pol beta-14 mutant in cells lacking APN1 activity does not result in an increase in the spontaneous mutation rate. These results suggest that gaps are required for mutagenesis to occur in the presence of Pol beta-14 but that it is not merely the presence of a gap that results in mutagenesis. Our results suggest that mutagenesis can occur during the gap-filling step of base excision repair in vivo. 相似文献
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JH Viles JB Mitchell SL Gough PM Doyle CJ Harris PJ Sadler JM Thornton 《Canadian Metallurgical Quarterly》1996,242(2):352-362
The aqueous solution structure of the cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-) has been determined by two-dimensional 1H-NMR spectroscopy, combined with a conformational search and distance-geometry calculations. As many as five conformers in slow exchange were observed, and the rate of interconversion between components was measured from the build-up rates of exchange peaks. NMR data allowed the structures of the two predominant conformers to be determined. The major component (66%) contained a cis-proline as part of a type-VIa2 beta-turn encompassing residues Asp-Val-cis-Pro-Ser. The second component (16%) contained only trans-amide bonds, and a type-VIII beta-turn formed by residues Val-Pro-Ser-D-Leu. These structures are discussed in relation to the (phi, psi), space available to the cyclic pentapeptide, determined by a conformational search, and in relation to previously published cyclic-pentapeptide structures. The molecule exhibits activity in a scintillation-proximity assay for the inhibition of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular-cell-adhesion molecule-1 (VCAM-1). The structure/activity relationship of the LDV sequence is discussed and related to the recently published X-ray structure of VCAM-1. The relevance of the work to the design of anti-inflammatory drugs is discussed. 相似文献
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David Crooks 《电子产品世界》2003,(18):46-48
作为一家专业机柜生产厂商,所生产的产品主要在恶劣的环境中为电气和电子部件提供保护,有时客户会要求厂商现场协助解决一些设计和使用中碰到的问题。进行现场评估时,会经常发现基本的机柜设计并没有问题,导致问题的是一些其它因素。有时是安装不正确。例如,安装不正确的液体密封导管配件或电缆衬垫会导致灰尘或水进入机柜,幸运的是,此类问题通常在安装后不久就可发现并可快速解决。然而,对于那些需要数月或数年时间才会逐渐显现的问题怎么办?暖气炉在每个取暖季节前都会进行清洁,每3000英里汽车机油也需要更换,我们自己更是(或应该)进行例… 相似文献
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