Data management and analysis for high-throughput DNA sequencingprojects

The rapid advances in molecular biology have begun to shift many of the bottlenecks in genome research from the laboratory to the data analysis facility. The pace at which this has occurred creates a situation in which software development always has to catch up with the flow of data. Since such large-scale processes were not anticipated, the analysis infrastructure has not been fully established. Furthermore, most systems that have been built were designed by the biologists who collected the data. More recently, computer scientists, mathematicians, and engineers have taken an interest in this problem. This has had a positive effect, since it has created a tight synergy between the informatics and the biology. Several principles affected the design of the system developed at TIGR. Each of the sample preparation, sequencing, and analysis steps had to be managed, scheduled, and tracked. This information had to be made readily available to those who needed it for carrying out their tasks. Different skill levels of the users had to be taken into account. The degree of human intervention at each step had to be evaluated and built into the design. A mixed processing environment of Macintosh and Unix platforms had to be integrated. Most importantly, the system had to save time, reduce error, and ensure uniformity of the analysis and quality of the results. In the authors' experience, the tools they have built work well because of their early decisions as to which systems to use for development. The authors settled on a robust relational database management system (Sybase) and a portable development environment (C, C++)     

Structured genetic algorithm for robust H∞ controlsystems design

A structured genetic algorithm (SGA) approach is developed for robust controller design based on the concept of an H^∞ loop-shaping technique and the method of inequalities. Such an SGA is capable of simultaneously searching the orders and coefficients of the precompensator and postcompensator for the weighted plant. It is, therefore, not necessary to predefine the order of compensators as in usual practice. A multiple objective ranking approach is also incorporated so that the design criteria of extreme plants can be easily achieved. The effectiveness of such a technique is illustrated by a high-purity distillation column design example     

Genetic algorithms: concepts and applications [in engineeringdesign]

This paper introduces genetic algorithms (GA) as a complete entity, in which knowledge of this emerging technology can be integrated together to form the framework of a design tool for industrial engineers. An attempt has also been made to explain “why” and “when” GA should be used as an optimization tool     

蒸汽发生器二次侧清洁度的视频检查

立式平管板Ｕ形管束的压水堆核电站蒸汽发生器安装至瞬变工况期间，管板上表面的铁基金属残余物的堆积和外来物的存在，以及商业运行后管板、传热管、管子支撑板等的低流速区域里沉积物的堆积要求进行蒸汽发生器的清洁度检查。介绍了蒸汽发生器二次侧清洁度的视频检查技术。该技术适用于蒸汽发生器安装至瞬变工况和投入商业运行后可能发生污染的各阶段的清洁度检查。     

辨识时变系统遗忘因子算法的收敛性分析

著名的递推遗忘因子算法（ＲＦＦＡ）可以用辨识时变系统参数，具有良好的跟踪性能，本文借助于随机过程理论分析了ＲＦＦＡ的收敛性和稳定性，给出了参数跟踪误差的上下界。     

转炉炼钢静态模型的初步探讨

根据转炉炼钢的物理化学反应机理，从质量平衡和能量平衡的计算出发，通过小参数变动，导出了增量式静态模型中矿石方程和供氧方程的系数。所得结论与新日铁资料基本相符。同时，还进行了炉料和产物的计算，分析了改变废钢比对生产的影响。     

复合果胶酶加工番石榴果汁的工艺优化

采用法国产的复合液态果胶酶加工番石榴果汁。研究结果表明,最佳工艺条件为:每千克番石榴果浆加入20mL浓度为0.01mL/mL的复合液态果胶酶、pH为3.5、45℃下恒温酶解5￣6h。使用不同的澄清剂对番石榴果汁进行澄清,结果表明,加浓度为0.5%的明胶溶液20mL/kg果汁中的效果最佳。番石榴果汁,保持了原有果实的营养成分和保健功能,有独特的风味。     

Syntax and consistent equation semantics of hybrid Chi

The hybrid χ (Chi) formalism integrates concepts from dynamics and control theory with concepts from computer science, in particular from process algebra and hybrid automata. It integrates ease of modeling with a straightforward, structured operational semantics. Its ‘consistent equation semantics’ enforces state changes to be consistent with delay predicates, that combine the invariant and flow clauses of hybrid automata. Ease of modeling is ensured by means of the following concepts: (1) different classes of variables: discrete and continuous, of subclass jumping or non-jumping, and algebraic; (2) strong time determinism of alternative composition in combination with delayable guards; (3) integration of urgent and non-urgent actions; (4) differential algebraic equations as a process term as in mathematics; (5) steady-state initialization; and 6) several user-friendly syntactic extensions. Furthermore, the χ formalism incorporates several concepts for complex system specification: (1) process terms for scoping that integrate abstraction, local variables, local channels and local recursion definitions; (2) process definition and instantiation that enable process re-use, encapsulation, hierarchical and/or modular composition of processes; and (3) different interaction mechanisms: handshake synchronization and synchronous communication that allow interaction between processes without sharing variables, and shared variables that enable modular composition of continuous-time or hybrid processes. The syntax and semantics are illustrated using several examples.     

Microstructure and Mechanical Properties of Heat-treated GeSb_2Te_4 Thin Films

The effect of annealing on microstructure,adhesive and frictional properties of GeSb 2 Te 4 films were experimentally studied.The GeSb 2 Te 4 films were prepared by radio frequency(RF)magnetron sputtering,and annealed at 200℃and 340℃under vacuum circumstance,respectively.The adhesion and friction experiments were mainly conducted with a lateral force microscope(LFM)for the GeSb 2 Te 4 thin films before and after annealing.Their morphology and phase structure were analyzed by using atomic force microscopy(AFM)and X-ray Diffraction(XRD)techniques,and the nanoindention was employed to evaluate their hardness values.Moreover,an electric force microscope(EFM)was used to measure the surface potential. It is found that the deposited GeSb 2 Te 4 thin film undergoes an amorphous-to-fcc and fcc-to-hex structure transition;the adhesion has a weaker dependence on the surface roughness,but a certain correlation with the surface potential of GeSb 2 Te 4 thin films.And the friction behavior of GeSb 2 Te 4 thin films follows their adhesion behavior under a lower applied load.However,such a relation is replaced by the mechanical behavior when the load is relatively higher.Moreover,the GeSb 2 Te 4 thin film annealed at 340℃presents a lubricative property.     

室外LED显示及其在交通领域的应用

介绍了室外LED显示技术及其在道路交通信息显示领域中的应用,指出目前国内室外LED显示屏普遍存在的主要问题.结合应用于高速公路收费站的LED显示屏的设计,给出解决或者克服这些问题的方法.介绍了室外LED显示的现状,预测了其发展趋势.