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131.
Hassan H. Martinez J.-M. Dominguez C. Perles A. Albaladejo J. 《Education, IEEE Transactions on》2004,47(4):446-452
An innovative educational methodology adapted to the requirements of a new era with new societal and industrial challenges for electronic engineers is proposed in this paper. This active methodology, known as the Educational Innovation Project (EIP), is being studied in the Electronic Engineering (EE) degree of the Higher Technical School of Design Engineering at the Polytechnic University of Valencia, Valencia, Spain. The main objective of the EIP methodology is to improve the process of teaching and learning in order to increase student success. To accomplish this objective, the EIP method addresses various issues. From an organizational viewpoint, different structural aspects of the EE degree have been adapted, such as balancing and integrating lectures and laboratory sessions, advancing into interdisciplinary studies coordinated among all the subjects of the course, and strengthening the work in teams to tackle real engineer problems. The industrial computer engineering (ICE) subject is taken as a reference to show how these aspects have been applied. Regarding the faculty, lecturers participate in an open and permanent process of further training; attitudes toward cooperation and exchanges of experience among them are promoted; and research and reflection on new methodologies is encouraged. One of the challenges of the implementation of the EIP project is the development of multidisciplinary projects by team workers. The knowledge acquired from all the subjects is put into practice through the development of a common project to undertake real engineering problems. 相似文献
132.
This paper presents characteristic analysis of without permanent magnet brushless DC (WPMBLDC) motor by using three-dimensional (3-D) finite element method (FEM). The paper describes the complex magnetic structure and principle of the presented WPMBLDC motor in detail. The magnetic field distribution of the presented motor is numerically computed by 3-D FEM. The primary characteristics of the motor including magnetic flux density, flux linkage and inductance profile are obtained. A prototype WPMBLDC machine has also been built and tested; additionally, the accuracy of 3-D FE analysis is verified by comparing the calculated results with the experimental measured values. 相似文献
133.
Ghulam Muhammad Muhammad Hussain Muneer Al-Hammadi Hatim Aboalsamh Hassan Mathkour Amir Saeed Malik 《Behaviour & Information Technology》2016,35(11):958-967
ABSTRACTThe effect of 2D and 3D educational content learning on memory has been studied using electroencephalography (EEG) brain signal. A hypothesis is set that the 3D materials are better than the 2D materials for learning and memory recall. To test the hypothesis, we proposed a classification system that will predict true or false recall for short-term memory (STM) and long-term memory (LTM) after learning by either 2D or 3D educational contents. For this purpose, EEG brain signals are recorded during learning and testing; the signals are then analysed in the time domain using different types of features in various frequency bands. The features are then fed into a support vector machine (SVM)-based classifier. The experimental results indicate that the learning and memory recall using 2D and 3D contents do not have significant differences for both the STM and the LTM. 相似文献
134.
Sentiment analysis involves the detection of sentiment content of text using natural language processing. Natural language processing is a very challenging task due to syntactic ambiguities, named entity recognition, use of slangs, jargons, sarcasm, abbreviations and contextual sensitivity. Sentiment analysis can be performed using supervised as well as unsupervised approaches. As the amount of data grows, unsupervised approaches become vital as they cut down on the learning time and the requirements for availability of a labelled dataset. Sentiment lexicons provide an easy application of unsupervised algorithms for text classification. SentiWordNet is a lexical resource widely employed by many researchers for sentiment analysis and polarity classification. However, the reported performance levels need improvement. The proposed research is focused on raising the performance of SentiWordNet3.0 by using it as a labelled corpus to build another sentiment lexicon, named Senti‐CS. The part of speech information, usage based ranks and sentiment scores are used to calculate Chi‐Square‐based feature weight for each unique subjective term/part‐of‐speech pair extracted from SentiWordNet3.0. This weight is then normalized in a range of ?1 to +1 using min–max normalization. Senti‐CS based sentiment analysis framework is presented and applied on a large dataset of 50000 movie reviews. These results are then compared with baseline SentiWordNet, Mutual Information and Information Gain techniques. State of the art comparison is performed for the Cornell movie review dataset. The analyses of results indicate that the proposed approach outperforms state‐of‐the‐art classifiers. 相似文献
135.
Raghu Ramanathan Ahmad Hassan Ali Jamal A. Ibdah 《International journal of molecular sciences》2022,23(13)
Nonalcoholic fatty liver disease (NAFLD) is a global pandemic that affects one-quarter of the world’s population. NAFLD includes a spectrum of progressive liver disease from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis and can be complicated by hepatocellular carcinoma. It is strongly associated with metabolic syndromes, obesity, and type 2 diabetes, and it has been shown that metabolic dysregulation is central to its pathogenesis. Recently, it has been suggested that metabolic- (dysfunction) associated fatty liver disease (MAFLD) is a more appropriate term to describe the disease than NAFLD, which puts increased emphasis on the important role of metabolic dysfunction in its pathogenesis. There is strong evidence that mitochondrial dysfunction plays a significant role in the development and progression of NAFLD. Impaired mitochondrial fatty acid oxidation and, more recently, a reduction in mitochondrial quality, have been suggested to play a major role in NAFLD development and progression. In this review, we provide an overview of our current understanding of NAFLD and highlight how mitochondrial dysfunction contributes to its pathogenesis in both animal models and human subjects. Further we discuss evidence that the modification of mitochondrial function modulates NAFLD and that targeting mitochondria is a promising new avenue for drug development to treat NAFLD/NASH. 相似文献
136.
Angeli Ambayya Anthony V. Moorman Jameela Sathar Jeyanthy Eswaran Sarina Sulong Rosline Hassan 《International journal of molecular sciences》2022,23(1)
Hitherto, no data describing the heterogeneity of genetic profiles and risk stratifications of adult acute myeloid leukaemia (AML) in Southeast Asia are reported. This study assessed genetic profiles, Moorman’s hierarchical classification, and ELN 2017-based risk stratifications in relation to age, gender, and ethnicity in Malaysian adult AML patients. A total of 854 AML patients: male (52%), female (48%) were recruited comprising three main ethnic groups: Malays (59%), Chinese (32%) and Indians (8%). Of 307 patients with abnormal karyotypes: 36% exhibited translocations; 10% deletions and 5% trisomies. The commonest genotype was FLT3-ITD-NPM1wt (276/414; 66.7%). ELN 2017 risk stratification was performed on 494 patients, and 41% were classified as favourable, 39% as intermediate and 20% as adverse groups. More females (47%) were in the favourable risk group compared to males (37%), whereas adverse risk was higher in patients above 60 (24%) of age compared to below 60 (18%) patients. We observed heterogeneity in the distribution of genetic profiles and risk stratifications between the age groups and gender, but not among the ethnic groups. Our study elucidated the diversity of adult AML genetic profiles between Southeast Asians and other regions worldwide. 相似文献
137.
Abdullah Y. Hassan Sairah Yousaf Moran R. Levin Osamah J. Saeedi Saima Riazuddin Janet L. Alexander Zubair M. Ahmed 《International journal of molecular sciences》2022,23(1)
Congenital cataracts (CC) are responsible for approximately one-tenth of childhood blindness cases globally. Here, we report an African American family with a recessively inherited form of CC. The proband demonstrated decreased visual acuity and bilateral cataracts, with nuclear and cortical cataracts in the right and left eye, respectively. Exome sequencing revealed a novel homozygous variant (c.563A > G; p.(Asn188Ser)) in GJA3, which was predicted to be pathogenic by structural analysis. Dominantly inherited variants in GJA3 are known to cause numerous types of cataracts in various populations. Our study represents the second case of recessive GJA3 allele, and the first report in African Americans. These results validate GJA3 as a bona fide gene for recessively inherited CC in humans. 相似文献
138.
Tahreem Fiaz Muhammad Shahid Nadeem Obaid Afzal Abdulmalik S. A. Altamimi Sami I. Alzarea Waleed Hassan Almalki Hafsa Ahmed Khan Iahtisham-Ul-Haq Sharoon Hanook Imran Kazmi Muhammad Mustafa 《International journal of molecular sciences》2022,23(22)
Emotional stress is believed to be associated with increased tumor progression. Stress-induced epigenetic modifications can contribute to the severity of disease and poor prognosis in cancer patients. The current study aimed to investigate the expression profiles along with the prognostic significance of psychological stress-related genes in metastatic breast cancer patients, to rationalize the molecular link between emotional stress and cancer progression. We profiled the expression of selected stress-associated genes (5-HTT, NR3C1, OXTR, and FKBP5) in breast cancer including the stress evaluation of all participants using the Questionnaire on Distress in Cancer Patients–short form (QSC-R10). A survival database, the Kaplan–Meier Plotter, was used to explore the prognostic significance of these genes in breast cancer. Our results showed relatively low expressions of 5-HTT (p = 0.02) and OXTR (p = 0.0387) in metastatic breast cancer patients as compared to the non-metastatic group of patients. The expression of NR3C1 was low in tumor grade III as compared to grade II (p = 0.04). Additionally, the expression of NR3C1 was significantly higher in patients with positive estrogen receptor status. However, no significant difference was found regarding FKBP5 expression in breast cancer. The results suggest a potential implication of these genes in breast cancer pathology and prognosis. 相似文献
139.
140.
Mohamed Gamal Mohamed Maha Mohamed Samy Tharwat Hassan Mansoure Chia-Jung Li Wen-Cheng Li Jung-Hui Chen Kan Zhang Shiao-Wei Kuo 《International journal of molecular sciences》2022,23(1)
There is currently a pursuit of synthetic approaches for designing porous carbon materials with selective CO2 capture and/or excellent energy storage performance that significantly impacts the environment and the sustainable development of circular economy. In this study we prepared a new bio-based benzoxazine (AP-BZ) in high yield through Mannich condensation of apigenin, a naturally occurring phenol, with 4-bromoaniline and paraformaldehyde. We then prepared a PA-BZ porous organic polymer (POP) through Sonogashira coupling of AP-BZ with 1,3,6,8-tetraethynylpyrene (P-T) in the presence of Pd(PPh3)4. In situ Fourier transform infrared spectroscopy and differential scanning calorimetry revealed details of the thermal polymerization of the oxazine rings in the AP-BZ monomer and in the PA-BZ POP. Next, we prepared a microporous carbon/metal composite (PCMC) in three steps: Sonogashira coupling of AP-BZ with P-T in the presence of a zeolitic imidazolate framework (ZIF-67) as a directing hard template, affording a PA-BZ POP/ZIF-67 composite; etching in acetic acid; and pyrolysis of the resulting PA-BZ POP/metal composite at 500 °C. Powder X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, and Brunauer–Emmett–Teller (BET) measurements revealed the properties of the as-prepared PCMC. The PCMC material exhibited outstanding thermal stability (Td10 = 660 °C and char yield = 75 wt%), a high BET surface area (1110 m2 g–1), high CO2 adsorption (5.40 mmol g–1 at 273 K), excellent capacitance (735 F g–1), and a capacitance retention of up to 95% after 2000 galvanostatic charge–discharge (GCD) cycles; these characteristics were excellent when compared with those of the corresponding microporous carbon (MPC) prepared through pyrolysis of the PA-BZ POP precursors with a ZIF-67 template at 500 °C. 相似文献