The Well Mannered Wearable Computer

In this paper we describe continuing work being carried out as part of the Bristol Wearable Computing Initiative. We are interested in the use of context sensors to improve the usefulness of wearable computers. A CyberJacket incorporating a Tourist Guide application has been built, and we have experimented with location and movement sensing devices to improve its performance. In particular, we have researched processing techniques for data from accelerometers which enable the wearable computer to determine the user’s activity. We have experimented with, and review, techniques already employed by others; and then propose new methods for analysing the data delivered by these devices. We try to minimise the number of devices needed, and use a single X-Y accelerometer device. Using our techniques we have adapted our CyberJacket and Tourist Guide to include a multimedia presentation which gives the user information using different media depending on the user’s activity as well as location.     

A 640 by 480 Pixels Readout Circuit for IR Imaging

A readout circuit for a 640 × 480 pixels FPA (focal plane array) has been successfully designed, fabricated and tested. The circuit solution is based on a per pixel source-follower direct injection (SFDI) pre-amplifier. Signal multiplexing is performed in both X and Y direction. The pixel size is 25 m × 25m. The chip is optimized for a QWIP (quantum well infrared photodetector) operating at a temperature of 70 K. The circuit has been realized in a standard 0.8 m CMOS process.     

On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry

Liquid chromatography (LC) was coupled on-line to a continuous-flow enzymatic assay using electrospray ionization mass spectrometry (ESI-MS) as readout for the screening of enzyme inhibitors in complex samples. Inhibitors were detected by changes in the concentration of the enzymatic reaction products, indicating the inhibition of enzymatic activity. The molecular masses of the inhibitors were determined with high certainty by using retention time matching and peak shape comparison. Due to the high matching accuracy, baseline separation of coeluting analytes was not necessary in order to identify the correct masses of the bioactive compounds. The continuous-flow system was successfully applied for the screening of complex samples, such as natural extracts. For a red clover extract, detection limits of 0.3-0.8 micromol/L were obtained. System validation was performed by determining the IC(50) values of four inhibitors in the flow-injection mode. The IC(50) values were in the 0.11-5.6 micromol/L range and correspond closely to data obtained by microtiter plate assays. Detection limits were in the range of 0.018-0.35 micromol/L in the flow-injection mode, and 0.075-0.75 micromol/L in the LC mode. These values are well below the typical compound concentrations (1-10 micromol/L) used in high-throughput screening. Together with an interday precision of 12.6%, these results demonstrate the applicability of the system for bioactivity screening of complex mixtures, generating both chemical and biological information on bioactive compounds in a single run.     

Computer-controlled mechanical simulation of the artificially ventilated human respiratory system

A mechanical lung simulator can be used to simulate specific lung pathologies, to test lung-function equipment, and in instruction. A new approach to mechanical simulation of lung behavior is introduced that uses a computer-controlled active mechatronic system. The main advantage of this approach is that the static and dynamic properties of the simulator can easily be adjusted via the control software. A nonlinear single-compartment mathematical model of the artificially ventilated respiratory system has been derived and incorporated into the simulator control system. This model can capture both the static and dynamic compliance of the respiratory system as well as nonlinear flow-resistance properties. Parameters in this model can be estimated by using data from artificially ventilated patients. It is shown that the simulation model fits patient data well. This mathematical model of the respiratory system was then matched to a model of the available physical equipment (the simulator, actuators, and the interface electronics) in order to obtain the desired lung behavior. A significant time delay in the piston motion control loop has been identified, which can potentially cause oscillations or even instability for high compliance values. Therefore, a feedback controller based on the Smith-predictor scheme was developed to control the piston motion. The control system, implemented on a personal computer, also includes a user-friendly interface to allow easy parameter setting.     

How effective is intermittent chlorination to control adult mussel fouling in cooling water systems?

Mussel control in cooling water systems is generally achieved by means of chlorination. Chlorine is applied continuously or intermittently, depending on cost and discharge criteria. In this paper, we examined whether mussels will be able to survive intermittent chlorination because of their ability to close their valves during periods of chlorination. Experiments were carried out using three common species of mussels: a freshwater mussel, Dreissena polymorpha, a brackish water mussel, Mytilopsis leucophaeata and a marine mussel, Mytilus edulis. The mussels were subjected to continuous or intermittent (4 h chlorination followed by 4 h no chlorination) chlorination at concentrations varying from 1 to 3 mg l(-1) and their responses (lethal and sublethal) were compared to those of control mussels. In addition, shell valve activity of mussels was monitored using a Mussel-monitor. Data clearly indicate that mussels shut their valves as soon as chlorine is detected in the environment and open only after chlorine dosing is stopped. However, under continuous chlorination mussels are constrained to keep the shell valves shut continuously. The mussels subjected to continuous chlorination at 1 mg l(-1) showed 100% mortality after 588 h (D. polymorpha), 966 h (Mytilus edulis) and 1104 h (Mytilopsis leucophaeata), while those subjected to intermittent chlorination at 1 mg l(-1) showed very little or no mortality during the same periods. Filtration rate, foot activity index and shell valve movement of D. polymorpha, Mytilopsis leucophaeata and Mytilus edulis decreased more than 90% at 1 mg l(-1) chlorine residual when compared to control. However, mussels subjected to intermittent chlorination showed a similar reduction (about 90%) in filtration rate, foot activity index and shell valve movement during chlorination and 3% during breaks in chlorination. The data indicate that intermittent chlorination between 1 and 3 mg l(-1) applied at 4 h on and 4 h off cycle is unlikely to control biofouling if mussels are the dominant fouling organisms.     

An application-centric evaluation of OpenCL on multi-core CPUs

Although designed as a cross-platform parallel programming model, OpenCL remains mainly used for GPU programming. Nevertheless, a large amount of applications are parallelized, implemented, and eventually optimized in OpenCL. Thus, in this paper, we focus on the potential that these parallel applications have to exploit the performance of multi-core CPUs. Specifically, we analyze the method to systematically reuse and adapt the OpenCL code from GPUs to CPUs. We claim that this work is a necessary step for enabling inter-platform performance portability in OpenCL.     

Positron Annihilation Investigation of Embrittlement Behavior in Chinese RPV Steels after Fe-Ion IrradiationEI北大核心CSCD

The reactor pressure vessel (RPV) is the key component in the nuclear power plant, which is considered irreplaceable and can be the life-limiting feature of the operation of nuclear power plant if its mechanical properties degrade sufficiently. High temperature gas-cooled reactor (HTGR) has perfect inherent safety, which is intended to be one of the fourth generation advanced nuclear reactors. However, HTGR has different service temperature with pressurized water reactor (PWR), that the service temperature of HTGR is 250 degrees C and that of PWR is 290 degrees C. So the irradiation behaviour of RPV in HTGR is expected to be investigated. In this wok, 3 MeV Fe-ion irradiation was performed on Chinese A508-3 reactor pressure vessel steel which is employed by high-temperature gas-cooled reactors and pure Fe under room temperature (about 25 degrees C) and high temperature (250 degrees C). The ion doses were 0.1, 0.5 and 1.0 dpa for both room temperature irradiation and high temperature irradiation. SRIM modeling was performed before irradiation experiments to guide the experimental details. Positron annihilation Doppler broadening (PADB) spectroscopy experiments and nano-indentation tests (to study embrittlement behavior) were conducted for characterization. It is found that after both room temperature irradiation and high temperature irradiation, the densities of defects in the reactor pressure vessel steel and pure Fe increase, and the type of defects could be vacancy-type and solute cluster type from PADB results. The vacancy-type defect density under high temperature irradiation is lower than that under room temperature irradiation. That is because high temperature can recover the defects formed during irradiation. The hardness test results show that for both the reactor pressure vessel steel and pure Fe, the irradiation hardening increases with increasing dose. Compared to room temperature irradiation, high temperature irradiation can produce more solute clusters and fewer vacancy-type defects in the reactor pressure vessel steel. So the irradiation hardening of the reactor pressure vessel steel might be caused mainly by the formation of solute clusters.