全文获取类型
收费全文 | 472篇 |
免费 | 34篇 |
国内免费 | 7篇 |
专业分类
电工技术 | 21篇 |
化学工业 | 95篇 |
金属工艺 | 24篇 |
机械仪表 | 26篇 |
建筑科学 | 29篇 |
能源动力 | 27篇 |
轻工业 | 29篇 |
水利工程 | 9篇 |
石油天然气 | 3篇 |
无线电 | 42篇 |
一般工业技术 | 87篇 |
冶金工业 | 14篇 |
原子能技术 | 1篇 |
自动化技术 | 106篇 |
出版年
2024年 | 2篇 |
2023年 | 6篇 |
2022年 | 20篇 |
2021年 | 26篇 |
2020年 | 29篇 |
2019年 | 31篇 |
2018年 | 43篇 |
2017年 | 35篇 |
2016年 | 34篇 |
2015年 | 20篇 |
2014年 | 31篇 |
2013年 | 55篇 |
2012年 | 36篇 |
2011年 | 42篇 |
2010年 | 18篇 |
2009年 | 7篇 |
2008年 | 11篇 |
2007年 | 15篇 |
2006年 | 3篇 |
2005年 | 8篇 |
2004年 | 3篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
排序方式: 共有513条查询结果,搜索用时 15 毫秒
21.
In vitro evaluation of spray‐dried chitosan microspheres crosslinked with pyromellitic dianhydride for oral colon‐specific delivery of protein drugs
下载免费PDF全文
![点击此处可从《应用聚合物科学杂志》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Chitosan microspheres have been prepared using a spray‐drying method, and crosslinked with pyromellitic dianhydride. The chemical structure of the modified chitosan was characterized by FTIR spectroscopy and solid state 13C NMR analysis. The particle size and morphology of the crosslinked chitosan were investigated. These microspheres were evaluated for colon‐specific delivery of bovine serum albumin (BSA) as a model protein drug. The results indicate that the drug was released as follows: 37.1 ± 2.8% after 2 h in SGF, 73.1 ± 4.8% after 8 h (2 h in SGF+ 6 h in SIF), and 80.9 ± 4.1% after 12 h in SCF. The effect of β‐glucosidase on the drug release was also examined. The encapsulation efficiency was decreased from 88.4 ± 3.1% to 62.8 ± 2.9%, with increasing BSA concentration. Loading capacity was significantly increased from 6.3 ± 0.3% to 41.8 ± 4.1% by increasing the initial BSA concentration. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40514. 相似文献
22.
Dr. Liam J. Stephens Dr. Aviva Levina Dr. Iman Trinh Dr. Victoria L. Blair Dr. Melissa V. Werrett Prof. Peter A. Lay Prof. Philip C. Andrews 《Chembiochem : a European journal of chemical biology》2020,21(8):1188-1200
RuII-arene complexes provide a versatile scaffold for novel anticancer drugs. Seven new RuII-arene-thiocarboxylato dimers were synthesized and characterized. Three of the complexes ( 2 a , b and 5 ) showed promising antiproliferative activities in MDA-MB-231 (human invasive breast cancer) cells, and were further tested in a panel of fifteen cancerous and noncancerous cell lines. Complex 5 showed moderate but remarkably selective activity in MDA-MB-231 cells (IC50=39±4 μm Ru). Real-time proliferation studies showed that 5 induced apoptosis in MDA-MB-231 cells but had no effect in A549 (human lung cancer, epithelial) cells. By contrast, 2 a and b showed moderate antiproliferative activity, but no apoptosis, in either cell line. Selective cytotoxicity of 5 in aggressive, mesenchymal-like MDA-MB-231 cells over many common epithelial cancer cell lines (including noninvasive breast cancer MCF-7) makes it an attractive lead compound for the development of specifically antimetastatic Ru complexes with low systemic toxicity. 相似文献
23.
In this study, the influence of various concentrations of dichromate and chloride ions on critical pitting temperature (CPT) of duplex stainless steel 2205 (DSS 2205) is investigated by employing potentiodynamic and potentiostatic CPT measurement methods. Potentiostatic results indicate that by adding 0.01 M to 0.1 M NaCl solution the CPT raised by 12 °C. Based on potentiodynamic CPT measurements in the solutions with ratio equal to one for solutions containing 0.1 M NaCl + 0.1 M and 0.01 M NaCl + 0.01 M , no CPT was detected up to 75 °C. 相似文献
24.
In this work, the corrosion behaviour of metal matrix composite plain carbon steel–B4C was studied in 3·5 wt-%NaCl solution. The composite was locally produced as weld band on plain carbon steel by means of gas tungsten arc welding process and using nickel as wetting agent. Samples from weld band, heat affected zone and base regions were extracted precisely, and electrochemical techniques including open circuit potential, linear polarisation resistance, electrochemical impedance spectroscopy, potentiodynamic polarisation in combination with SEM-EDX surface analysis and microhardness were used for characterisation. The results showed that hardness value of made composite increased significantly to 642 HV10. However, the corrosion resistance of composite region during 7 days (168 h) of exposure to 3·5 wt-%NaCl solution was slightly reduced. This was attributed to the fact that B4C particles play as cathode site for oxygen reduction; therefore, they increase the corrosion rate slightly. 相似文献
25.
The effects of hydrocolloids in rice–wheat flour were studied. Hydrocolloids at 0%, 0.3%, 0.6% and 1% w/w (flour basis) and guar (G), Lepidium sativum seed (L) and guar-L. sativum seed (GL) gum were tested as additives to the rice/flour in various combinations. The quality parameters for the experiment were assessed with farinography, extensography, amylography and texture profile analysis. The evaluation of dough rheology showed that water absorption, dough development time, dough stability and viscosity all increased with the addition of hydrocolloids alone or in a combination. It was demonstrated that G1L1 promoted the highest effect. The mixing tolerance index and gelatinization temperature decreased with an increased hydrocolloid concentration. Extensibility value for the dough that incorporated guar and L. sativum seed gum increased with increasing hydrocolloid concentration from 0.3% to 0.6% and then decreased at 1%. The water activity of all bread didn't have significant differences with increasing hydrocolloids concentration but this parameter 24 decreased during storage. Firmness decreased with increasing hydrocolloid concentration and increased with increasing storage time. The sensory evaluation by a consumer panel gave the higher score for overall acceptability to G0.3L0.3 and G0.3L0.6 samples. The results also showed that G1L1, G1L0.6 and G0.6L1 samples had high specific volume and porosity. 相似文献
26.
Muhammad Iman Utama Abdul Aziz Ammar Nokeun Park Eung Ryul Baek 《Metals and Materials International》2018,24(2):291-299
We studied the origin of different characteristics and properties of a Ti–10V–2Fe–3Al beta (β) titanium alloy with surface height irregularities that occurred during machining. The height differences were observed in two different regions, labeled as “soft region” and “hard region.” The present study showed a higher Fe and a lower Al content in the hard region, which resulted in higher β-phase stability to resist primary alpha (αp) phase precipitation caused by a failure of the solution treatment process. In contrast, the soft region contained a higher volume fraction of αp phase and a lower volume fraction of the matrix, which consisted of a combination of β and secondary alpha (αs) phase. A high number of αs/β interface in the matrix with a predicted hardness of 520 HV generated an improvement of hardness in the hard region. Therefore, the hard and the soft regions had different abilities to resist wear during machining process, resulting in surface height irregularities. 相似文献
27.
Majid Kermani Masoud Farzaneh László E. Kollár 《Journal of Wind Engineering & Industrial Aerodynamics》2010,98(10-11):592-599
Aeolian vibration in bare and iced cable was simulated using the theory of cable vibration. High frequency vibration creates stresses in the cable and consequently in the ice covering that cable, which may result in ice failure and eventually ice shedding. These stresses were estimated in this study. Displacement of the cable during vibration was determined; furthermore, instantaneous wind loads in vertical and transverse directions, additional stresses induced by the motion in the cable and in the atmospheric ice, as well as torque due to cable springback were calculated. In order to simulate the loading conditions of a chunk of atmospheric ice in the middle of a span, a new model was developed using ABAQUS. Results from this model show in spite of high frequency vibration, the resulting level of stress in atmospheric ice is far less than its failure limit. In other words, the atmospheric ice under the condition assumed in this investigation does not shed due to aeolian vibration. 相似文献
28.
Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia 总被引:1,自引:0,他引:1
Davoodi R. Andrews B.J. Wheeler G.D. Lederer R. 《IEEE transactions on neural systems and rehabilitation engineering》2002,10(3):197-203
Concept 2 indoor rowing machine (Concept 2 Inc., USA) was modified for functional electrical stimulation (FES) rowing exercise in paraplegia. A new seating system provides trunk stability and constrains the leg motion to the sagittal plane. A 4-channel electrical stimulator activates the quadriceps and hamstrings in Drive and Recovery phases of the rowing cycle, respectively. Two force-sensing resistors (FSR) on the handle measure the thumb press as the command signal to the electrical stimulator. Optical encoders measure the positions of the seat and handle during rowing. To synchronize the voluntarily controlled upper body movement with the FES controlled leg movement, a novel manual control system was developed. It uses the voluntary thumb presses to control the timing of the stimulation to the paralyzed leg muscles. The manual control system was intuitive and easy to learn and resulted in well-coordinated rowing. Evaluation of the modified rower by paraplegic volunteers showed that it is effective, safe, and affordable exercise alternative for paraplegics. 相似文献
29.
Permeability of stressed concrete 总被引:4,自引:0,他引:4
Abdy Kermani 《Building Research & Information》1991,19(6):360-366
Abdy Kermani of the Structural Research Group at the Department of Civil Engineering, Napier Polytechnic of Edinburgh, found that permeability increases with increase in applied stress level depending on the type of the mix and the magnitude of the applied pressure. He also found that additives, which affect the composition, strength and propagation of micro cracks in concrete, can also have a significant influence on permeability. 相似文献
30.
An indoor personal rowing machine (Concept 2 Inc., Morrisville, VT) has been modified for functional electrical stimulation assisted rowing exercise in paraplegia. To successfully perform the rowing maneuver, the voluntarily controlled upper body movements must be coordinated with the movements of the electrically stimulated paralyzed legs. To achieve such coordination, an automatic controller was developed that employs two levels of hierarchy. A high level finite state controller identifies the state or phase of the rowing motion and activates a low-level state-dedicated fuzzy logic controller (FLC) to deliver the electrical stimulation to the paralyzed leg muscles. A pilot study with participation of two paraplegic volunteers showed that FLC spent less muscle energy, and produced smoother rowing maneuvers than the existing On-Off constant-level stimulation controller. 相似文献