AN EXPERT SYSTEM FOR ACADEMIC COUNSELING

In recent years, high enrollment has greatly increased the counseling loads of academic advisors at American colleges and universities. Expert systems can assist academic counselors by solving a relatively easy class of problems which deal with the most encountered cases. In this paper, a prototype expert system, CLASS COUNSELOR, is presented. CLASS COUNSELOR recommends a set of courses after an interactive session with the student. It handles the upper division courses of the undergraduate program in the Department of Electrical Engineering, University of Florida. The program runs on IBM-AT personal computers and compatibles.     

<i>In Silico</i> analysis and linking of metabolism-related genes with the immune landscape in head and neck squamous cell carcinoma

Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head and neck squamous cell carcinoma (HNSCC). The integrative analysis of all the metabolism-related genes (MRGs) in HNSCC is lacking and the interaction between the metabolism and the immune characteristics also requires more exploration to uncover the potential mechanisms. Therefore, this study was designed to establish a prognostic signature based on all the MRGs in HNSCC. Genes of HNSCC samples were available from the TCGA and GEO databases while the MRGs were retrieved from a previous study. Ultimately 4 prognostic MRGs were selected to construct a model possessing robust prognostic value and accuracy in TCGA cohorts. The favorable reproducibility of this model was confirmed in validation cohorts from GEO databases. The risk score calculated by this model was an independent prognostic factor that further classified these HNSCC patients into high-/low-risk groups. GSEA analyses and somatic mutations indicated the low-risk group could activate several anti-tumor pathways and possessed lower TP53 mutation. The results of ESTIMATE, single-sample GSEA, CIBERSORT, and some immune-related molecules analyses suggested the low-risk group exhibited lower metabolic activities and higher immune characteristics. The Spearman correlation test implied most metabolic pathways with tumor-promoting function were negatively correlated with the immune activity, indicating a plausible approach of combining the anti-metabolism and the immunotherapy drugs in the high-risk group to enhance therapeutic effects than applied separately. In conclusion, this prognostic signature linking MRGs with the immune landscape could promote the individualized treatment for HNSCC patients.     

LA TRANSFORMATION D'UN POSTE DE TRAVAIL; SES REPERCUSSIONS SUR LA FATIGUE

L'étudedecriteci-dessoussest acheveeen4étapes: 1. L'analysed'un postede travail en fonction dc ses exigences psycho-physiologiques. 2. La critique de son aménagement du point de vue de Teffort visuel et de la définition de l'aire de travail. 3. La transformation d'un poste servant de prototype selon quelques regies ergonomiques. 4. La verification de la valeur de cette transformation à l'aide d'un test de “fatigue”     

Titanium diffusion in shinbone of rats with osseointegrated implants

Dental implants are composed of commercially pure Ti (which is actually an alloy of titanium, and minor or trace components such as aluminium and vanadium). When the implant is inserted, its surface undergoes a number of chemical and mechanical processes, releasing particles of titanium to the medium. The metabolism of free ions of titanium is uncertain; the uptaking processes in the body are not well known, nor their toxic dose. In addition, physical properties of newly formed bone, such as diffusivity and activation energy, are scarce and rarely studied. In this study, we analysed the diffusion of titanium in the titanium‐implanted shinbones of six adult male Wistar rats by spatially resolved micro x‐ray fluorescence. The measurements were carried out at the microfluorescence station of the x‐ray fluorescence (XRF) beamline of the Brazilian synchrotron facility LNLS (from Portuguese ‘Laboratorio Nacional de Luz Sincrotron’). For each sample, XRF spectra were taken by linear scanning in area near the new bone formed around the Ti implant. The scanning line shows a clear effect of titanium diffusion whereas calcium intensity presents a different behaviour. Moreover, a clear correlation among the different structures of bones is observed in the Ti and Ca intensities. The results obtained in these measurements may allow determining quantitatively the parameters of diffusion rates and other physical properties of new bone like diffusion coefficients.     

Advanced spinning disk‐TIRF microscopy for faster imaging of the cell interior and the plasma membrane

Understanding the cellular processes that occur between the cytosol and the plasma membrane is an important task for biological research. Till now, however, it was not possible to combine fast and high‐resolution imaging of both the isolated plasma membrane and the surrounding intracellular volume. Here, we demonstrate the combination of fast high‐resolution spinning disk (SD) and total internal reflection fluorescence (TIRF) microscopy for specific imaging of the plasma membrane. A customised SD‐TIRF microscope was used with specific design of the light paths that allowed, for the first time, live SD‐TIRF experiments at high acquisition rates. A series of experiments is shown to demonstrate the feasibility and performance of our setup.     

航空复杂件精铸蜡模数控成型新工艺研究

提出采用NC多轴数控铣削加工工艺直接得到适合精度要求的航空复杂件的精密铸造用蜡模,克服了有模蜡模制造周期长、成本高及无模蜡模快速成型精度低的缺点,实现了航空复杂件精铸蜡模的无模快速精确成型,更好地满足了新机研制对于航空复杂件少量、快速、高精度的要求,对于航空工业的发展意义重大.     

基于CP2200的嵌入式系统以太网接口设计

随着单片机处理能力不断增强,嵌入式系统也越复杂,控制系统日趋网络化,使基于以太网的嵌入式系统研究成为其技术发展的趋势。本文以ATmega16单片机和CP2200以太网控制器为主要硬件,TCP/IP为协议,分析了嵌入式单片机系统接入以太网的可行性,并阐述了其硬件设计,软件设计与实时性。