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排序方式: 共有1458条查询结果,搜索用时 15 毫秒
31.
Júlia Faura Laura Ramiro Alba Simats Feifei Ma Anna Penalba Teresa Gasull Anna Rosell Joan Montaner Alejandro Bustamante 《International journal of molecular sciences》2022,23(15)
After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performed transient middle cerebral artery occlusion (MCAO) and sham surgery on C57BL/6J mice and collected bronchoalveolar lavage fluid (BALF), serum, brain, and lung homogenate samples 24 h after surgery. A 92 proteins-panel developed by Olink Proteomics® was used to analyze the content in BALF and lung homogenates. MCAO animals had higher protein concentration levels in BALF than sham-controls, but these levels did not correlate with the infarct volume. No alteration in alveolar-capillary barrier permeability was observed. A total of 12 and 14 proteins were differentially expressed between the groups (FDR < 0.1) in BALF and lung tissue homogenates, respectively. Of those, HGF, TGF-α, and CCL2 were identified as the most relevant to this study. Their protein expression patterns were verified by ELISA. This study confirmed that post-stroke lung damage was not associated with increased lung permeability or cerebral ischemia severity. Furthermore, the dysregulation of HGF, TGF-α, and CCL2 in BALF and lung tissue after ischemia could play an important role in the molecular mechanisms underlying stroke-induced lung damage. 相似文献
32.
Zakir M. Hirani Zia Bukhari Joan Oppenheimer Patrick Jjemba Mark W. LeChevallier Joseph G. Jacangelo 《Water research》2013
Membrane bioreactors (MBRs) are often a preferred treatment technology for satellite water recycling facilities since they produce consistent effluent water quality with a small footprint and require little or no supervision. While the water quality produced from centralized MBRs has been widely reported, there is no study in the literature addressing the effluent quality from a broad range of satellite facilities. Thus, a study was conducted to characterize effluent water qualities produced by satellite MBRs with respect to organic, inorganic, physical and microbial parameters. Results from sampling 38 satellite MBR facilities across the U.S. demonstrated that 90% of these facilities produced nitrified (NH4-N <0.4 mg/L-N) effluents that have low organic carbon (TOC <8.1 mg/L), turbidities of <0.7 NTU, total coliform bacterial concentrations <100 CFU/100 mL and indigenous MS-2 bacteriophage concentrations <21 PFU/100 mL. Multiple sampling events from selected satellite facilities demonstrated process capability to consistently produce effluent with low concentrations of ammonia, TOC and turbidity. UV-254 transmittance values varied substantially during multiple sampling events indicating a need for attention in designing downstream UV disinfection systems. Although enteroviruses, rotaviruses and hepatitis A viruses (HAV) were absent in all samples, adenoviruses were detected in effluents of all nine MBR facilities sampled. The presence of Giardia cysts in filtrate samples of two of nine MBR facilities sampled demonstrated the need for an appropriate disinfection process at these facilities. 相似文献
33.
Claudia Nurra Luizildo Pitol‐Filho Raphaelle Carraud Said Pertuz Domènec Puig Miguel A. García Joan Salvadó Carles Torras 《Polymer Engineering and Science》2016,56(1):118-124
One of the challenges in membrane technology is predicting permeability in porous membranes for liquid applications in an easy and inexpensive way. This is the aim of this work. To achieve this objective, several techniques can be considered. In this study, a morphological approach from two‐dimensional scanning electron micrographs is proposed. First, numerical membrane morphological parameters have been determined from micrographs by using the QUANTS tool, which applies a texture recognition process. Second, the obtained data have been fit to the Darcy's and Hagen–Poiseuille models to calculate permeations. The QUANTS results have also been compared with the ones obtained through a mercury porosimeter, which is a classic and well‐known methodology. Each parameter of the Hagen–Poiseuille model has been analyzed. A comparison between experimentally measured permeations and calculated ones has been performed. An even easier approach is proposed to predict flow rate with the only knowledge of membrane surface mean pore size. This method is based on cross‐section pore size interpolation by using function fits from surface mean pore sizes. The obtained results show a reasonable agreement between measured and computed results, making this technique a valid approach for predicting membrane permeability. POLYM. ENG. SCI., 56:118–124, 2016. © 2015 Society of Plastics Engineers 相似文献
34.
Miguel A. Salido Joan Escamilla Adriana Giret Federico Barber 《The International Journal of Advanced Manufacturing Technology》2016,84(5-8):1303-1312
Many real-world scheduling problems are solved to obtain optimal solutions in term of processing time, cost, and quality as optimization objectives. Currently, energy-efficiency is also taken into consideration in these problems. However, this problem is NP-hard, so many search techniques are not able to obtain a solution in a reasonable time. In this paper, a genetic algorithm is developed to solve an extended version of the Job-shop Scheduling Problem in which machines can consume different amounts of energy to process tasks at different rates (speed scaling). This problem represents an extension of the classical job-shop scheduling problem, where each operation has to be executed by one machine and this machine can work at different speeds. The evaluation section shows that a powerful commercial tool for solving scheduling problems was not able to solve large instances in a reasonable time, meanwhile our genetic algorithm was able to solve all instances with a good solution quality. 相似文献
35.
Danuta Kuzmicz Paul Coupillaud Yongjun Men Joan Vignolle Giordano Vendraminetto Martina Ambrogi Daniel Taton Jiayin Yuan 《Polymer》2014
Ionic liquid-functionalized mesoporous polymeric networks with specific surface area up to 935 m2/g have been successfully synthesized one pot by solvothermal copolymerization of divinylbenzene and monomeric ionic liquids. The as-obtained polymers exhibit a monolithic structure featuring large pore volumes, an abundant mesoporosity and an adjustable content of ionic liquids. The effect of the reaction conditions on the pore structure has been studied in detail. These poly(ionic liquid)-based porous networks (PILPNs) have then been employed as precursors in two distinct applications, namely organocatalysis and production of microporous carbon monoliths. Selected organocatalyzed reactions, including carbonatation of propylene oxide by cycloaddition with carbon dioxide, benzoin condensation, and cyanosilylation of benzaldehyde have been readily triggered by PILPNs acting as crosslinked polymer-supported (pre)catalysts. The two latter reactions required the prior deprotonation of the imidazolium salt units with a strong base to successfully generate polymer-supported N-heterocyclic carbenes, referred to as poly(NHC)s. Facile recycling and reuse of polymer-supported (pre)catalysts was achieved by simple filtration owing to the heterogeneous reaction conditions. Furthermore, PILPNs could be easily converted into microporous carbon monoliths via CO2 activation. 相似文献
36.
Joan E. Haysom Omid Jafarieh Hanan Anis Karin Hinzer David Wright 《Progress in Photovoltaics: Research and Applications》2015,23(11):1678-1686
Price declines and volume growth of concentrated photovoltaic (CPV) systems are analysed using the learning curve methodology and compared with other forms of solar electricity generation. Logarithmic regression analysis determines a learning rate of 18% for CPV systems with 90% confidence of that rate being between 14 and 22%, which is higher than the learning rates of other solar generation systems (11% for CSP and 12 to 14% for PV). Current CPV system prices are competitive with PV and CSP, which, when combined with the higher learning rate, indicates that CPV is likely to further improve its marketability. A target price of 1 $/W in 2020 could be achieved with a compound growth rate of 67% for the total deployed volume between 2014 and 2020, which would realize a cumulative deployed volume of 7900 MW. Other projections of deployment volumes from commercial sources are converted using the learning rate into future price scenarios, resulting in predicted prices in the range of 1.1 to 1.3 $/W in 2020. © 2014 The Authors. Progress in Photovoltaics: Research and Applications published by John Wiley & Sons Ltd. 相似文献
37.
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39.
Sara Gonzlez-García Carles M. Gasol Xavier Gabarrell Joan Rieradevall Mª Teresa Moreira Gumersindo Feijoo 《Renewable & Sustainable Energy Reviews》2009,13(9):2613-2620
One of the main challenges faced by mankind in the 21st century is to meet the increasing demand for energy requirements by means of a more sustainable energy supply. In countries that are net fossil fuel importers, expectation about the benefit of using alternative fuels on reducing oil imports is the primary driving force behind efforts to promote its production and use. Spain is scarce in domestic energy sources and more than 50% of the energy used is fossil fuel based. The promotion of renewable energies use is one of the principal vectors in the Spanish energy policy. Selected herbaceous crops such as Brassica carinata are currently under study as potential energy sources. Its biomass can be considered as potential feedstock to ethanol conversion by an enzymatic process due to the characteristics of its composition, rich in cellulose and hemicellulose. This paper aims to analyse the environmental performance of two ethanol-based fuel applications (E10 and E85) in a passenger car (E10 fuel: a mixture of 10% ethanol and 90% gasoline by volume; E85 fuel: a mixture of 85% ethanol and 15% gasoline by volume) as well as their comparison with conventional gasoline as transport fuel. Two types of functional units are applied in this study: ethanol production oriented and travelling distance oriented functional units in order to reflect the availability or not of ethanol supply. E85 seems to be the best alternative when ethanol production based functional unit is considered in terms of greenhouse gas (GHG) emissions and E10 in terms of non-renewable energy resources use. Nevertheless, E85 offers the best environmental performance when travelling distance oriented functional unit is assumed in both impacts. In both functional unit perspectives, the use of ethanol-based fuels reduces the global warming and fossil fuels consumption. However, the contributions to other impact indicators (e.g. acidification, eutrophication and photochemical oxidants formation) were lower for conventional gasoline.Life Cycle Assessment (LCA) procedure helps to identify the key areas in the B. carinata ethanol production life cycle where the researchers and technicians need to work to improve the environmental performance. Technological development could help in lowering both the environmental impact and the prices of the ethanol fuels. 相似文献
40.
The n-6/n-3 fatty acid (FA) ratio has increased in the Western-style diet to ~10–15:1 during the last century, which may have
contributed to the rise in cardiovascular disease (CVD). Prior studies have evaluated the effects on CVD risk factors of manipulating
the levels of n-6 and n-3 FA using food and supplements or investigated the metabolic fate of linoleic acid (LNA) and α-linolenic
acid (ALA) by varying the n-6/n-3 ratios. However, no previous studies have investigated the potential interaction between
diet ratios and supplementation with eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). We used
a factorial design approach with adults (n = 24) in a controlled feeding trial to compare the accretion of EPA and DHA into red blood cell membranes (RBC) by adding
a direct source (algal oil supplement) of EPA and DHA in a diet with a 10:1 versus 2:1 ratio of n-6/n-3 FA. Subjects were
randomized into 8-week crossover diet sequences and each subject consumed three of four diets [10:1, 10:1 plus supplement
(10:1 + S), 2:1 and 2:1 + S]. LNA and ALA intakes were 9.4 and 7.7%, and 1.0 and 3.0% during the low and high ALA diets, respectively.
Compared to the Western-style 10:1 diet, the 2:1 diet increased EPA by 60% (P < 0.0001) in RBC membranes without the direct EPA source and a 34% increase (P = 0.027) was observed with the 10:1 + S diet; however, DHA levels increased in both diet ratios only with a direct DHA source.
Shifting towards a 2:1 diet is a valid alternative to taking EPA-containing supplements. 相似文献